Diana Bellavia
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View article: Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets
Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets Open
This pilot study highlights the potential role of NGS analysis on solid biopsy in the assessment of the mutational profile of lung NET. A comparison of germline and somatic mutations is critical to identifying putative tumor driver mutatio…
View article: Immunotherapy in recurrent/metastatic head and neck squamous cell carcinoma: PD-L1 and beyond
Immunotherapy in recurrent/metastatic head and neck squamous cell carcinoma: PD-L1 and beyond Open
Head and neck squamous cell carcinoma (HNSCC) is a prominent global health concern because of its high incidence, aggressive clinical behavior, and scarce therapeutic options. The management of these neoplasms in the recurrent/metastatic s…
View article: Supplementary Data from Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance
Supplementary Data from Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance Open
The supplementary material file contains additional data that sustain the oncogenic role of Jag1-ICD and information about reagents utilized, as follows: - Supplementary Figure S1 recapitulates the main gene mutations in CRC cell lines . -…
View article: Data from Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance
Data from Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance Open
Colorectal cancer is characterized by well-known genetic defects and approximately 50% of cases harbor oncogenic Ras mutations. Increased expression of Notch ligand Jagged1 occurs in several human malignancies, including colorectal …
View article: Data from Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance
Data from Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance Open
Colorectal cancer is characterized by well-known genetic defects and approximately 50% of cases harbor oncogenic Ras mutations. Increased expression of Notch ligand Jagged1 occurs in several human malignancies, including colorectal …
View article: Supplementary Data from Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance
Supplementary Data from Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance Open
The supplementary material file contains additional data that sustain the oncogenic role of Jag1-ICD and information about reagents utilized, as follows: - Supplementary Figure S1 recapitulates the main gene mutations in CRC cell lines . -…
View article: Loss of <scp>ATP2C1</scp> function promotes trafficking and degradation of <scp>NOTCH1</scp>: Implications for Hailey‐Hailey disease
Loss of <span>ATP2C1</span> function promotes trafficking and degradation of <span>NOTCH1</span>: Implications for Hailey‐Hailey disease Open
Hailey‐Hailey disease (HHD) is a rare autosomal dominantly inherited disorder caused by mutations in the ATP2C1 gene that encodes an adenosine triphosphate (ATP)‐powered calcium channel pump. HHD is characterized by impaired epidermal cell…
View article: Identification of a Novel Curcumin Derivative Influencing Notch Pathway and DNA Damage as a Potential Therapeutic Agent in T-ALL
Identification of a Novel Curcumin Derivative Influencing Notch Pathway and DNA Damage as a Potential Therapeutic Agent in T-ALL Open
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy considered curable by modern clinical management. Nevertheless, the prognosis for T-ALL high-risk cases or patients with relapsed and refractory disease …
View article: 5FU/Oxaliplatin-Induced Jagged1 Cleavage Counteracts Apoptosis Induction in Colorectal Cancer: A Novel Mechanism of Intrinsic Drug Resistance
5FU/Oxaliplatin-Induced Jagged1 Cleavage Counteracts Apoptosis Induction in Colorectal Cancer: A Novel Mechanism of Intrinsic Drug Resistance Open
Colorectal cancer (CRC) is characterized by early metastasis, resistance to anti-cancer therapy, and high mortality rate. Despite considerable progress in the development of new treatment options that improved survival benefits in patients…
View article: When Viruses Cross Developmental Pathways
When Viruses Cross Developmental Pathways Open
Aberrant regulation of developmental pathways plays a key role in tumorigenesis. Tumor cells differ from normal cells in their sustained proliferation, replicative immortality, resistance to cell death and growth inhibition, angiogenesis, …
View article: Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy
Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy Open
Colorectal cancer (CRC) mortality is mainly caused by patient refractoriness to common anti-cancer therapies and consequent metastasis formation. Besides, the notorious toxic side effects of chemotherapy are a concurrent obstacle to be tac…
View article: A Dynamic Role of Mastermind-Like 1: A Journey Through the Main (Path)ways Between Development and Cancer
A Dynamic Role of Mastermind-Like 1: A Journey Through the Main (Path)ways Between Development and Cancer Open
Major signaling pathways, such as Notch, Hedgehog (Hh), Wnt/β-catenin and Hippo, are targeted by a plethora of physiological and pathological stimuli, ultimately resulting in the modulation of genes that act coordinately to establish speci…
View article: Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response
Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response Open
View article: PLK1 targets NOTCH1 during DNA damage and mitotic progression
PLK1 targets NOTCH1 during DNA damage and mitotic progression Open
View article: Wnt, Notch, and TGF-β Pathways Impinge on Hedgehog Signaling Complexity: An Open Window on Cancer
Wnt, Notch, and TGF-β Pathways Impinge on Hedgehog Signaling Complexity: An Open Window on Cancer Open
Constitutive activation of the Hedgehog (Hh) signaling pathway is associated with increased risk of developing several malignancies. The biological and pathogenic importance of Hh signaling emphasizes the need to control its action tightly…
View article: ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP Open
View article: Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype
Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype Open
Triple-negative breast cancer (TNBC) is a subgroup of 15%-20% of diagnosed breast cancer patients. It is generally considered to be the most difficult breast cancer subtype to deal with, due to the lack of estrogen receptor (ER), progester…
View article: Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression
Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression Open
Acute lymphoblastic leukemia (ALL) is the most common cancer among children. Recent advances in chemotherapy have made ALL a curable hematological malignancy. In children, there is 25% chance of disease relapse, typically in the central ne…
View article: Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL
Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL Open
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer caused by the deregulation of key T-cell developmental pathways, including Notch signaling. Aberrant Notch signaling in T-ALL occurs by NOTCH1 gain-of-functio…
View article: A Simplified Genomic Profiling Approach Predicts Outcome in Metastatic Colorectal Cancer
A Simplified Genomic Profiling Approach Predicts Outcome in Metastatic Colorectal Cancer Open
The response of metastatic colorectal cancer (mCRC) to the first-line conventional combination therapy is highly variable, reflecting the elevated heterogeneity of the disease. The genetic alterations underlying this heterogeneity have bee…
View article: Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells
Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells Open
Notch signaling is frequently activated in ovarian cancer (OC) and contributes to the proliferation and survival of cultured OC cells as well as to tumor formation and angiogenesis in xenograft models. Several studies demonstrate that Notc…
View article: EZH2, HIF-1, and Their Inhibitors: An Overview on Pediatric Cancers
EZH2, HIF-1, and Their Inhibitors: An Overview on Pediatric Cancers Open
During the past decades, several discoveries have established the role of epigenetic modifications and cellular microenvironment in tumor growth and progression. One of the main representatives concerning epigenetic modification is the pol…
View article: Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer
Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer Open
The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-κB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological condit…
View article: Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation
Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation Open
View article: PO-393 Notch3 and CXCR4 cross-signalling sustains acute T-cell leukaemia progression
PO-393 Notch3 and CXCR4 cross-signalling sustains acute T-cell leukaemia progression Open
and SMART technology, in conjunction with two novel nextgeneration sequencing (NGS) library preparation kits, using the same primer pairs, to capture full-length variable regions of TCR-a and -b chains.Material and methods Method 1, using …
View article: NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest
NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest Open
Notch dysregulation has been implicated in numerous tumors, including triple-negative breast cancer (TNBC), which is the breast cancer subtype with the worst clinical outcome. However, the importance of individual receptors in TNBC and the…
View article: Loss of miR-107, miR-181c and miR-29a-3p Promote Activation of Notch2 Signaling in Pediatric High-Grade Gliomas (pHGGs)
Loss of miR-107, miR-181c and miR-29a-3p Promote Activation of Notch2 Signaling in Pediatric High-Grade Gliomas (pHGGs) Open
The mechanisms by which microRNAs control pediatric high-grade gliomas (pHGGs) have yet to be fully elucidated. Our studies of patient-derived pHGG tissues and of the pHGG cell line KNS42 revealed down-regulation in these tumors of three m…
View article: Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway
Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway Open
View article: Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression
Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression Open
View article: The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBPα
The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBPα Open