Diana C. F. Monteiro
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View article: Cell-penetrant peptides as novel inhibitors of the interaction of coatomer protein COPB2/RACK2 with protein kinase Cε and cargo proteins
Cell-penetrant peptides as novel inhibitors of the interaction of coatomer protein COPB2/RACK2 with protein kinase Cε and cargo proteins Open
The lipid-activated novel protein kinase C isoform, PKCε, plays a key role in the progression of Type 2 Diabetes Mellitus (T2DM) and has also been implicated in cancer, cardiac hypertrophy, pain and anxiety. As the spatial regulation of PK…
View article: Analysis of apo and citraconate-bound hACOD1 (hIRG1) by X-ray crystallography and NMR spectroscopy: Structural insights for developing chemotherapeutic agents
Analysis of apo and citraconate-bound hACOD1 (hIRG1) by X-ray crystallography and NMR spectroscopy: Structural insights for developing chemotherapeutic agents Open
In this work, we present the high-resolution structure of human aconitate decarboxylase 1 (hACOD1) in its true apo form (active site empty) as well in complex with the inhibitor citraconate. These two new structures show the architecture o…
View article: <i>Burkholderia pseudomallei</i> rubrerythrin promiscuously binds metals in a structurally pre-formed bimetallic binding site
<i>Burkholderia pseudomallei</i> rubrerythrin promiscuously binds metals in a structurally pre-formed bimetallic binding site Open
Rubrerythrins are a group of proteins within the Ferritin-like superfamily that display a defining four-helix bundle domain. They also show multiple structural features that are crucial to their functionality as iron storage proteins and i…
View article: Abstract 1598 Targeting prolyl endopeptidase with cysteine-reactive covalent inhibitors
Abstract 1598 Targeting prolyl endopeptidase with cysteine-reactive covalent inhibitors Open
View article: Inhibition of prolyl endopeptidase through a noncatalytic active site residue
Inhibition of prolyl endopeptidase through a noncatalytic active site residue Open
Prolyl endopeptidase (PREP) is a serine protease that cleaves C-terminal to proline residues and represents an important drug target in several neurodegenerative diseases. PREP consists of a catalytic α/β-hydrolase domain and regulatory β-…
View article: Metalloproteins in emerging pathogens
Metalloproteins in emerging pathogens Open
Pathogens, such as bacteria, viruses, fungi, and protozoa, are constantly evolving and novel healthcare threats are frequently identified. The current race to find novel antimicrobials and overcome drug resistance is yet to win over the co…
View article: Abstract 2428: Structural investigations of rubrerythrin from B. pseudomallei: Metals, domain swapping, and other interesting features of this ferritin-like superfamily protein
Abstract 2428: Structural investigations of rubrerythrin from B. pseudomallei: Metals, domain swapping, and other interesting features of this ferritin-like superfamily protein Open
View article: Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers
Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers Open
View article: Preferences for Online Learning among Nursing Students: A Systematic Review
Preferences for Online Learning among Nursing Students: A Systematic Review Open
Background and objectives: The traditional teaching methods have transitioned to distance learning in all fields of education, including medical and nursing education during the Covid 19 pandemic. We aimed to perform a systematic review on…
View article: A Gilliat-Sumner hand with a mega transverse apophysis: A case report
A Gilliat-Sumner hand with a mega transverse apophysis: A case report Open
Thoracic outlet is a syndrome resulting from compression of neurovascular structures that pass through the outlet. Neurogenic thoracic outlet syndrome is the most frequent category, 90% of cases characterized by weakness and paresthesia of…
View article: The ideal crystal for structural biology
The ideal crystal for structural biology Open
The ideal crystal for structural biology can be defined as one that diffracts to sufficient resolution and completeness to answer the biological question being asked.While simply stated, that question can be asked in many ways and there is…
View article: Plug-and-play polymer microfluidic chips for hydrated room-temperature fixed-target serial crystallography
Plug-and-play polymer microfluidic chips for hydrated room-temperature fixed-target serial crystallography Open
The practice of serial X-ray crystallography (SX) depends on efficient, continuous delivery of hydrated protein crystals while minimizing background scattering. Of the two major types of sample delivery devices, fixed-target devices offer …
View article: Protein synchronization methods and considerations: light activation and rapid mixing
Protein synchronization methods and considerations: light activation and rapid mixing Open
Dynamically-resolved, or better known time-resolved (TR), structural studies of proteins require efficient methods for synchronized activation followed by delivery of the sample to the X-ray beam.Deciding on the correct method of activatio…
View article: Inhibition of SARS-CoV-2 main protease by allosteric drug-binding
Inhibition of SARS-CoV-2 main protease by allosteric drug-binding Open
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous health problems and economical challenges for mankind. To date, no effective drug is available to directly treat the disease and prevent virus spreading. In a s…
View article: Need for speed: Examining protein behaviour during cryoEM grid preparation at different timescales
Need for speed: Examining protein behaviour during cryoEM grid preparation at different timescales Open
A host of new technologies are under development to improve the quality and reproducibility of cryoEM grid preparation. Here we have systematically investigated the preparation of three macromolecular complexes using three different vitrif…
View article: Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease
Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease Open
Here we present the crystal structure of SARS-CoV-2 main protease (M pro ) covalently bound to 2-methyl-1-tetralone. This complex was obtained by co-crystallization of M pro with HEAT (2-(((4-hydroxyphenethyl)amino)methyl)-3,4-dihydronapht…
View article: 3D-MiXD: 3D-printed X-ray-compatible microfluidic devices for rapid, low-consumption serial synchrotron crystallography data collection in flow
3D-MiXD: 3D-printed X-ray-compatible microfluidic devices for rapid, low-consumption serial synchrotron crystallography data collection in flow Open
Please check the README.txt file from the supplementary files for more information about the dataset.
View article: 3D-MiXD: 3D-printed X-ray-compatible microfluidic devices for rapid, low-consumption serial synchrotron crystallography data collection in flow
3D-MiXD: 3D-printed X-ray-compatible microfluidic devices for rapid, low-consumption serial synchrotron crystallography data collection in flow Open
Please check the README.txt file from the supplementary files for more information about the dataset.
View article: Need for Speed: Examining Protein Behaviour During CryoEM Grid Preparation at Different Timescales
Need for Speed: Examining Protein Behaviour During CryoEM Grid Preparation at Different Timescales Open
View article: TREXX: a new endstation for serial time-resolved crystallography at PETRA III
TREXX: a new endstation for serial time-resolved crystallography at PETRA III Open
View article: A Cryo-EM Grid Preparation Device for Time-Resolved Structural Studies
A Cryo-EM Grid Preparation Device for Time-Resolved Structural Studies Open
Structural biology generally provides static snapshots of protein conformations that can inform on the functional mechanisms of biological systems. Time-resolved structural biology provides a means to visualise, at near-atomic resolution, …
View article: Megahertz serial crystallography
Megahertz serial crystallography Open
The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date…
View article: Sample triggering and delivery for time-resolved studies of proteins
Sample triggering and delivery for time-resolved studies of proteins Open
View article: Versatile and efficient rapid-mixing liquid jets
Versatile and efficient rapid-mixing liquid jets Open
View article: Versatile and efficient rapid-mixing liquid jets
Versatile and efficient rapid-mixing liquid jets Open
View article: Towards a generalised approach for the time-resolved crystallographic study of enzymes
Towards a generalised approach for the time-resolved crystallographic study of enzymes Open
View article: The Structure of the PanD/PanZ Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A
The Structure of the PanD/PanZ Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A Open