Diana D. Kang
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View article: Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency
Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency Open
View article: Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency
Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency Open
A significant challenge of mRNA-based protein replacement therapies is the diminishing efficacy and escalating toxicity associated with repeated dosing of lipid nanoparticles (LNPs). Many existing lipid formulations were originally designe…
View article: Lipid nanoparticles for mRNA delivery in brain via systemic administration
Lipid nanoparticles for mRNA delivery in brain via systemic administration Open
Efficient delivery of messenger RNA (mRNA) to the brain via systemic administration remains a challenge, primarily due to the blood-brain barrier. To address this challenge, we incorporated SR-57227, a ligand of serotonin [5-hydroxytryptam…
View article: SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo
SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo Open
Metastatic cancer, the primary cause of cancer mortality, frequently exhibits heightened dependence on certain transcription factors (TFs), which serve as master regulators of oncogenic signaling yet are often untargetable by small molecul…
View article: LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment
LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment Open
View article: Author Correction: Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system
Author Correction: Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system Open
View article: LPA1 antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities
LPA1 antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities Open
Activated fibroblasts are major mediators of pulmonary fibrosis. Fibroblasts are generally found in the connective tissue but upon activation can generate excess extracellular matrix (ECM) in the lung interstitial section. Therefore, fibro…
View article: The elucidation of species-specific receptor pharmacology: A case study using subtype-selective para- and meta-carborane estrogen receptor agonists
The elucidation of species-specific receptor pharmacology: A case study using subtype-selective para- and meta-carborane estrogen receptor agonists Open
Estrogen receptors (ERs) are essential pharmacological targets for treating hormonal disorders and estrogen-dependent malignancies. Selective activation of ERβ is hypothesized to provide therapeutic benefit with reduced risk of unwanted es…
View article: Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle–mRNA formulation
Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle–mRNA formulation Open
Current treatment options for diabetic wounds face challenges due to low efficacy, as well as potential side effects and the necessity for repetitive treatments. To address these issues, we report a formulation utilizing trisulfide-derived…
View article: Engineering LNPs with polysarcosine lipids for mRNA delivery
Engineering LNPs with polysarcosine lipids for mRNA delivery Open
Since the approval of the lipid nanoparticles (LNP)-mRNA vaccines against the SARS-CoV-2 virus, there has been an increased interest in the delivery of mRNA through LNPs. However, current LNP formulations contain PEG lipids, which can stim…
View article: LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing
LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing Open
View article: Close the cancer–immunity cycle by integrating lipid nanoparticle–mRNA formulations and dendritic cell therapy
Close the cancer–immunity cycle by integrating lipid nanoparticle–mRNA formulations and dendritic cell therapy Open
View article: Biomaterials for in situ cell therapy
Biomaterials for in situ cell therapy Open
Cell therapy has revolutionized the treatment of various diseases, such as cancers, genetic disorders, and autoimmune diseases. Currently, most cell therapy products rely on ex vivo cell engineering, which requires sophisticated manufactur…
View article: Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics
Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics Open
View article: STING Agonist-Derived LNP-mRNA Vaccine Enhances Protective Immunity Against SARS-CoV-2
STING Agonist-Derived LNP-mRNA Vaccine Enhances Protective Immunity Against SARS-CoV-2 Open
Lipid nanoparticle (LNP)-mediated delivery of messenger RNA (mRNA) COVID-19 vaccines has provided large-scale immune protection to the public. To elicit a robust immune response against SARS-CoV-2 infections, antigens produced by mRNAs enc…
View article: Nanomaterials‐Mediated Co‐Stimulation of Toll‐Like Receptors and CD40 for Antitumor Immunity
Nanomaterials‐Mediated Co‐Stimulation of Toll‐Like Receptors and CD40 for Antitumor Immunity Open
Toll‐like receptors (TLRs) and CD40‐related signaling pathways represent critical bridges between innate and adaptive immune responses. Here, an immunotherapy regimen that enables co‐stimulation of TLR7/8‐ and CD40‐mediated pathways is dev…
View article: Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy
Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy Open
View article: Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy
Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy Open
Antibodies targeting costimulatory receptors of T cells have been developed for the activation of T cell immunity in cancer immunotherapy. However, costimulatory molecule expression is often lacking in tumor-infiltrating immune cells, whic…
View article: Delivery of CRISPR-Cas9 system for screening and editing RNA binding proteins in cancer
Delivery of CRISPR-Cas9 system for screening and editing RNA binding proteins in cancer Open
View article: Construction of Messenger RNA (mRNA) Probes Delivered By Lipid Nanoparticles to Visualize Intracellular Protein Expression and Localization at Organelles
Construction of Messenger RNA (mRNA) Probes Delivered By Lipid Nanoparticles to Visualize Intracellular Protein Expression and Localization at Organelles Open
Organelles are specialized compartments, where various proteins reside and play crucial roles to maintain essential cellular structures and functions in mammalian cells. A comprehensive understanding of protein expressions and subsequent l…
View article: Ectopic expression of pericentric HSATII RNA results in nuclear RNA accumulation, MeCP2 recruitment, and cell division defects
Ectopic expression of pericentric HSATII RNA results in nuclear RNA accumulation, MeCP2 recruitment, and cell division defects Open
Within the pericentric regions of human chromosomes reside large arrays of tandemly repeated satellite sequences. Expression of the human pericentric satellite HSATII is prevented by extensive heterochromatin silencing in normal cells, yet…
View article: Harnessing lipid nanoparticles for efficient CRISPR delivery
Harnessing lipid nanoparticles for efficient CRISPR delivery Open
Lipid-based nanomaterials have shown to mediate specific and effective CRISPR delivery in vivo for the treatment of various diseases, including cancers, genetic disorders and infectious diseases.