Diana Fortkamp Grigoletto
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View article: Hydrogels and nanogels: effectiveness in dermal applications
Hydrogels and nanogels: effectiveness in dermal applications Open
Drug delivery systems (DDSs) are an important tool for obtaining medicines with improved physicochemical properties, especially for drugs with stability, absorption, and biodistribution impairments. Among the DDSs, we can highlight hydroge…
View article: Chemical and biological properties of nordihydroguaiaretic acid
Chemical and biological properties of nordihydroguaiaretic acid Open
Nordihydroguaiaretic acid (NDGA) is a natural product obtained by the alkaline extraction of dried plants of Larrea tridentata species. Due to the biological properties presented, such as antioxidant, anti-inflammatory, antiviral and cytot…
View article: Nanoparticles as a Tool for Broadening Antifungal Activities
Nanoparticles as a Tool for Broadening Antifungal Activities Open
Fungal infections are diseases that are considered neglected although their infection rates have increased worldwide in the last decades. Thus, since the antifungal arsenal is restricted and many strains have shown resistance, new therapeu…
View article: APOCYNIN, AN INHIBITOR OF THE NADPH OXIDASE COMPLEX
APOCYNIN, AN INHIBITOR OF THE NADPH OXIDASE COMPLEX Open
Apocynin is a phenolic compound isolated from the plant Picrorhiza kurroa Royle ex Benth. Such a compound has been extensively investigated for its therapeutic potential in diseases involving inflammatory processes or oxidative stress due …
View article: Secondary metabolites produced by endophytic fungi: novel antifungal activity of fumiquinone B
Secondary metabolites produced by endophytic fungi: novel antifungal activity of fumiquinone B Open
Fungi are present in the most diverse environments including the interior of plant tissues, living as endophytes without causing apparent damage. These endophytes are producers of secondary metabolites, also known as natural products, such…
View article: PHARMACOLOGICAL APPLICATIONS OF MELATONIN
PHARMACOLOGICAL APPLICATIONS OF MELATONIN Open
Melatonin was discovered by Lerner and Coworkers in 1958, and is the main product secreted by the pineal gland. It is a phylogenetically highly conserved molecule and one of the oldest biological signaling mechanisms. It presents several b…
View article: Gloeosporiocide, a new antifungal cyclic peptide from <i>Streptomyces morookaense</i> AM25 isolated from the Amazon bulk soil
Gloeosporiocide, a new antifungal cyclic peptide from <i>Streptomyces morookaense</i> AM25 isolated from the Amazon bulk soil Open
Actinobacteria are known by their ability to produce several antimicrobial compounds of biotechnological interest. Thus, in this study, we isolated and identified by partial 16S RNA sequencing ∼100 actinobacteria isolates from guarana (Pau…