Diana Iacob
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View article: In Vitro Activity of Cefiderocol Against Multi-Drug-Resistant Gram-Negative Clinical Isolates in Romania
In Vitro Activity of Cefiderocol Against Multi-Drug-Resistant Gram-Negative Clinical Isolates in Romania Open
Background/Objectives: Gram-negative bacteria with acquired carbapenem resistance have become increasingly common in serious infections. This study aimed to evaluate the in vitro activity of cefiderocol against multidrug-resistant Gram-neg…
View article: In Vitro – In Vivo Correlation of Pentoxifylline: A Comprehensive Kinetic Analysis
In Vitro – In Vivo Correlation of Pentoxifylline: A Comprehensive Kinetic Analysis Open
This study presents an analysis of In Vitro-In Vivo Correlation (IVIVC) for pentoxifylline modified-release tablets, with a focus on deriving robust predictive models. In vitro dissolution tests were conducted in three pH media (1.2, 4.5, …
View article: Food-effect study on the pharmacokinetics of indapamide prolonged-release tablets
Food-effect study on the pharmacokinetics of indapamide prolonged-release tablets Open
Objective A comparative study was performed to evaluate the food impact on the pharmacokinetics of indapamide 1.5 mg prolonged release tablets (SR). Methods The data evaluated were collected from 2 randomized, single dose, 2-way crossover …
View article: Honey Enriched with Additives Alleviates Behavioral, Oxidative Stress, and Brain Alterations Induced by Heavy Metals and Imidacloprid in Zebrafish
Honey Enriched with Additives Alleviates Behavioral, Oxidative Stress, and Brain Alterations Induced by Heavy Metals and Imidacloprid in Zebrafish Open
Environmental concerns have consistently been a focal point for the scientific community. Pollution is a critical ecological issue that poses significant threats to human health and agricultural production. Contamination with heavy metals …
View article: Trace Metal Bioaccumulation in Feral Pigeons (Columba livia f. domestica) and Rooks (Corvus frugilegus) Residing in the Urban Environment of Iasi City, Romania
Trace Metal Bioaccumulation in Feral Pigeons (Columba livia f. domestica) and Rooks (Corvus frugilegus) Residing in the Urban Environment of Iasi City, Romania Open
Nowadays, trace metal contamination within urban atmospheres is a significant and concerning global issue. In the present study, two synanthropic bird species, namely, the feral pigeon (Columba livia f. domestica) and the rook (Corvus frug…
View article: Trace element bioaccumulation in the plumage of common blackbirds (Turdus merula Linnaeus, 1758) from Agigea, Romania
Trace element bioaccumulation in the plumage of common blackbirds (Turdus merula Linnaeus, 1758) from Agigea, Romania Open
The purpose of this research was to establish the baseline concentrations of thirteen trace elements (Cd, Co, Cr, Cu, Ni, Pb, Fe, Mg, Na, K, Sr, Ca, and Zn) in feathers of the common blackbird Turdus merula (n=9) at the Natura 2000 site “M…
View article: Zebrafish as a Potential Model for Neurodegenerative Diseases: A Focus on Toxic Metals Implications
Zebrafish as a Potential Model for Neurodegenerative Diseases: A Focus on Toxic Metals Implications Open
In the last century, industrial activities increased and caused multiple health problems for humans and animals. At this moment, heavy metals are considered the most harmful substances for their effects on organisms and humans. The impact …
View article: Comprehensive Review Regarding Mercury Poisoning and Its Complex Involvement in Alzheimer’s Disease
Comprehensive Review Regarding Mercury Poisoning and Its Complex Involvement in Alzheimer’s Disease Open
Mercury (Hg) is considered one of the most widespread toxic environmental pollutants, which seems to have multiple effects on organisms even at low concentrations. It has a critical role in many health problems with harmful consequences, w…
View article: Infectious Threats, the Intestinal Barrier, and Its Trojan Horse: Dysbiosis
Infectious Threats, the Intestinal Barrier, and Its Trojan Horse: Dysbiosis Open
The ecosystem of the gut microbiota consists of diverse intestinal species with multiple metabolic and immunologic activities and it is closely connected with the intestinal epithelia and mucosal immune response, with which it builds a com…
View article: Intestinal Microbiota as a Host Defense Mechanism to Infectious Threats
Intestinal Microbiota as a Host Defense Mechanism to Infectious Threats Open
The intestinal microbiota is a complex microbial community, with diverse and stable populations hosted by the gastrointestinal tract since birth. This ecosystem holds multiple anti-infectious, anti-inflammatory, and immune modulating roles…
View article: The Rostlab Metaproteome Analysis Pipeline (RMAP)
The Rostlab Metaproteome Analysis Pipeline (RMAP) Open