Diana Jaquin
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View article: Diverse Responses of Autoantibodies to the Angiotensin II Type 1 Receptor in Primary Aldosteronism
Diverse Responses of Autoantibodies to the Angiotensin II Type 1 Receptor in Primary Aldosteronism Open
Primary aldosteronism is a common form of endocrine hypertension mainly caused by a unilateral aldosterone-producing adenoma (APA) or bilateral adrenal hyperplasia (BAH). AT1R-Abs (autoantibodies to the angiotensin II type 1 receptor) have…
View article: Primary Aldosteronism
Primary Aldosteronism Open
Aldosterone-producing adenomas with somatic mutations in the KCNJ5 G-protein–coupled inwardly rectifying potassium channel are a cause of primary aldosteronism. These mutations drive aldosterone excess, but their role in cell growth is und…