Diana Schnoegl
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View article: Machine learning assisted immune profiling of COPD identifies a unique emphysema subtype independent of GOLD stage
Machine learning assisted immune profiling of COPD identifies a unique emphysema subtype independent of GOLD stage Open
Chronic obstructive pulmonary disease (COPD) is a severe, progressive, and heterogeneous disease with a poor outcome. Inflammation plays a central role in disease pathogenesis; however, the interplay between immune changes and disease hete…
View article: AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity Open
The proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription fac…
View article: Fra-2 Is a Dominant Negative Regulator of Natural Killer Cell Development
Fra-2 Is a Dominant Negative Regulator of Natural Killer Cell Development Open
Natural killer (NK) cells play an important role in recognizing and killing pathogen-infected or malignant cells. Changes in their numbers or activation can contribute to several diseases and pathologies including systemic sclerosis (SSc),…
View article: Low oxygen levels decrease adaptive immune responses and ameliorate experimental asthma in mice
Low oxygen levels decrease adaptive immune responses and ameliorate experimental asthma in mice Open
Background High‐altitude therapy has been used as add‐on treatment for allergic asthma with considerable success. However, the underlying mechanisms remain unclear. In order to investigate the possible therapeutic effects of high‐altitude …
View article: Machine learning analysis of the bleomycin-mouse model reveals the compartmental and temporal inflammatory pulmonary fingerprint
Machine learning analysis of the bleomycin-mouse model reveals the compartmental and temporal inflammatory pulmonary fingerprint Open
Summary The bleomycin mouse-model is the extensively used model to study pulmonary fibrosis, however, the inflammatory cell kinetics and their compartmentalisation is still incompletely understood. Here we assembled historical flow cytomet…
View article: Transcription factor Fra-2 and its emerging role in matrix deposition, proliferation and inflammation in chronic lung diseases
Transcription factor Fra-2 and its emerging role in matrix deposition, proliferation and inflammation in chronic lung diseases Open
Fos-related antigen-2 (Fra-2) belongs to the activator protein 1 (AP-1) family of transcription factors and is involved in a broad variety of cellular processes, such as proliferation or differentiation. Aberrant expression of Fra-2 or reg…