Diane Erdmann
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View article: Identification of Chemical Probes Targeting MBD2
Identification of Chemical Probes Targeting MBD2 Open
Epigenetics has received much attention in the past decade. Many insights on epigenetic (dys)regulation in diseases have been obtained, and clinical therapies targeting them are in place. However, the readers of the epigenetic marks are la…
View article: Procainamide–SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites
Procainamide–SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites Open
Epigenetic post-translational modifications are essential for human malaria parasite survival and progression through its life cycle. Here, we present new functionalized suberoylanilide hydroxamic acid (SAHA) derivatives that chemically co…
View article: DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant <i>Plasmodium falciparum</i> Parasites
DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant <i>Plasmodium falciparum</i> Parasites Open
Malaria is the deadliest parasitic disease affecting over 200 million people worldwide. The increasing number of treatment failures due to multi-drug-resistant parasites in South-East Asia hinders the efforts for elimination. It is thus ur…
View article: XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii
XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii Open
View article: Espoirs et promesses de la méthylation de l’ADN et des histones comme cibles anticancéreuses
Espoirs et promesses de la méthylation de l’ADN et des histones comme cibles anticancéreuses Open