Diane Gage
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View article: Rare coding variants in ten genes confer substantial risk for schizophrenia
Rare coding variants in ten genes confer substantial risk for schizophrenia Open
View article: Ultra-rare disruptive and damaging mutations influence educational attainment in the general population
Ultra-rare disruptive and damaging mutations influence educational attainment in the general population Open
Disruptive and damaging ultra-rare variants (URVs) in highly constrained (HC) genes are enriched in individuals with neurodevelopmental disorders. In the general population, this class of variants was associated with a decrease in years of…
View article: Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders Open
View article: The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls
The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls Open
View article: Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry
Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry Open
View article: NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis
NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis Open
Schizophrenia, Schizoaffective, and Bipolar disorders share behavioral and phenomenological traits, intermediate phenotypes, and some associated genetic loci with pleiotropic effects. Volumetric abnormalities in brain structures are among …
View article: Genome-wide association study identifies 30 loci associated with bipolar disorder
Genome-wide association study identifies 30 loci associated with bipolar disorder Open
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4…
View article: Common variants of<i>NRXN1, LRP1B</i>and<i>RORA</i>are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study
Common variants of<i>NRXN1, LRP1B</i>and<i>RORA</i>are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study Open
Schizophrenia, Schizoaffective, and Bipolar Disorders share common illness traits, intermediate phenotypes and a partially overlapping polygenic basis. We performed GWAS on deep phenotyping data, including structural MRI and DTI, clinical,…
View article: Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder Open
Bipolar disorder is a highly heritable psychiatric disorder that features episodes of mania and depression. We performed the largest genome-wide association study to date, including 20,352 cases and 31,358 controls of European descent, wit…
View article: Ultra-rare disruptive and damaging mutations influence educational attainment in the general population
Ultra-rare disruptive and damaging mutations influence educational attainment in the general population Open
View article: Ultra-rare disruptive and damaging mutations influence educational attainment in the general population
Ultra-rare disruptive and damaging mutations influence educational attainment in the general population Open
Ultra-rare inherited and de novo disruptive variants in highly constrained (HC) genes are enriched in neurodevelopmental disorders 1–5 . However, their impact on cognition in the general population has not been explored. We hypothesize tha…
View article: Ultra-rare disruptive and damaging mutations influence educational attainment in the general population
Ultra-rare disruptive and damaging mutations influence educational attainment in the general population Open
Disruptive and damaging ultra-rare variants (URVs) in highly constrained (HC) genes are enriched in individuals with neurodevelopmental disorders. In the general population, this class of variants was associated with a decrease in years of…