Diane M. Becker
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View article: Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Open
Introduction: Genetic variants associated with nicotine dependence have previously been identified, primarily in European-ancestry populations. No genome-wide association studies (GWAS) have been reported for smoking behaviors in Hispanics…
View article: Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries
Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries Open
Summary Background Polygenic risk scores (PRSs) improve type 2 diabetes (T2D) prediction beyond clinical risk factors but perform poorly in non-European populations, where T2D burden is often higher, undermining their global clinical utili…
View article: WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE
WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE Open
Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study lev…
View article: Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma
Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma Open
US NIH/NHLBI grants: P01HL132825, K99HL159234. N01-HC-25195 and HHSN268201500001I.
View article: Clonal haematopoiesis and risk of chronic liver disease
Clonal haematopoiesis and risk of chronic liver disease Open
Chronic liver disease is a major public health burden worldwide1. Although different aetiologies and mechanisms of liver injury exist, progression of chronic liver disease follows a common pathway of liver inflammation, injury and fibrosis…
View article: Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function
Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function Open
Higher mtDNA CN in blood is associated with better current and future general cognitive function in large and diverse communities across the United States. Although MR analyses did not support a causal role, additional research is needed t…
View article: Genetic diversity fuels gene discovery for tobacco and alcohol use
Genetic diversity fuels gene discovery for tobacco and alcohol use Open
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury 1–4 . These substances are used across the globe, yet genome-wide a…
View article: Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals Open
Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. However, gene-metabolite integration has been primarily studied in individuals of European Ancestry, limiting the opportunit…
View article: Association of Vascular Properties With the Brain White Matter Hyperintensity in Middle‐Aged Population
Association of Vascular Properties With the Brain White Matter Hyperintensity in Middle‐Aged Population Open
Background The periventricular white matter is more sensitive to the systemic hemodynamic alterations than the deep white matter because of differences in its vascular structure and systemic circulation relationship. We hypothesize that pe…
View article: Addressing disparities in medicine through medical curriculum change: a student perspective
Addressing disparities in medicine through medical curriculum change: a student perspective Open
Cultural competency training has been a focus of medical schools for some time. An essential step in developing culturally competent physicians, effective cultural competency training has previously been researched at medical schools. Befo…
View article: Association of Coronary Artery Atherosclerosis With Brain White Matter Hyperintensity
Association of Coronary Artery Atherosclerosis With Brain White Matter Hyperintensity Open
Background and Purpose: We aim to determine, in healthy high-risk adults, the association between subclinical coronary artery disease and white matter hyperintensity (WMH) volume and location, independent of atherosclerotic risk factors. M…
View article: Genetic architecture of smoking: Evaluating rare variant contribution from deep whole-genome sequencing of up to 26,000 individuals
Genetic architecture of smoking: Evaluating rare variant contribution from deep whole-genome sequencing of up to 26,000 individuals Open
Background Across complex traits, common variants explain only a modest amount of variance, with SNP-heritability consistently below heritability estimates from close relatives. Here, we examined the contribution of rare variant to tobacco…