Diane Maisin
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View article: Haemoglobin Ottawa, sickle cell trait and vaso‐occlusive crises
Haemoglobin Ottawa, sickle cell trait and vaso‐occlusive crises Open
A girl with a sickle cell trait had severe VOCs (vaso‐occlusive crises), her father also had a sickle cell trait but mild VOCs, and her mother had no symptoms. Electrophoresis on agarose gel under alkaline conditions showed haemoglobin AS …
View article: CA125, Galectin-3 and FGF-23 are interrelated in heart failure with reduced ejection fraction.
CA125, Galectin-3 and FGF-23 are interrelated in heart failure with reduced ejection fraction. Open
Concentrations of CA125 are increased in patients with HFrEF, associated to disease severity and adverse cardiovascular outcomes. CA125 levels are also correlated to Galectin-3 and FGF-23, two biomarkers related to fibrosis and cardiovascu…
View article: Biological variation of CA 15-3, CA 125 and HE 4 on lithium heparinate plasma in apparently healthy Caucasian volunteers
Biological variation of CA 15-3, CA 125 and HE 4 on lithium heparinate plasma in apparently healthy Caucasian volunteers Open
Objectives Tumor markers are well-known for being important tools in the support of diagnosis, monitoring of treatment efficacy and follow-up of cancers. CA 125, CA 15-3 and HE 4 have demonstrated potential efficacy in other clinical indic…
View article: Value of DNA testing in the diagnosis of sickle‐cell anemia in childhood in an environment with a high prevalence of other causes of anemia
Value of DNA testing in the diagnosis of sickle‐cell anemia in childhood in an environment with a high prevalence of other causes of anemia Open
Background Sickle‐cell anemia (SCA) is the most common genetic disease worldwide caused by a single mutation in the gene HBB . DNA testing can help to clarify the diagnosis when Hb electrophoresis is inconclusive. We evaluated the usefulne…
View article: Biological variation and analytical goals of four thyroid function biomarkers in healthy European volunteers
Biological variation and analytical goals of four thyroid function biomarkers in healthy European volunteers Open
Background Interpretation of thyroid function tests by means of biological variation (BV) data is essential to identify significant changes between serial measurements at an individual level. Data on thyroid parameters in adults are limite…
View article: A rare case of tuberculosis-induced hypercalcemia
A rare case of tuberculosis-induced hypercalcemia Open
Laboratory investigations of hypercalcemia involve testing of various biochemical parameters such as parathyroid hormone (PTH), 25-(OH) Vitamin D (25-(OH) VitD), 1,25-(OH)2 Vitamin D3 (calcitriol) and PTH related peptide (PTHrp). We herein…
View article: A Challenging Case of Falsely Elevated Free Thyroid Hormones
A Challenging Case of Falsely Elevated Free Thyroid Hormones Open
CASE DESCRIPTION : The patient was a 73-year-old woman suffering from a right calcaneus (heel bone) fracture. She was treated with nebivolol, olmesartan, hydrochlorothiazide, and simvastatine for hypertension and hypercholesterolemia. The …