Diane Merino
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View article: Safety profile of belatacept in a real-life setting: disproportionality analysis of the WHO pharmacovigilance database
Safety profile of belatacept in a real-life setting: disproportionality analysis of the WHO pharmacovigilance database Open
View article: Evaluating and leveraging large language models in clinical pharmacology and therapeutics assessment: From exam takers to exam shapers
Evaluating and leveraging large language models in clinical pharmacology and therapeutics assessment: From exam takers to exam shapers Open
Aims In medical education, the ability of large language models (LLMs) to match human performance raises questions about their potential as educational tools. This study evaluates LLMs' performance on Clinical Pharmacology and Therapeutics…
View article: Apports des données en vie réelle à la sécurité des antipsychotiques chez l’enfant et l’adolescent
Apports des données en vie réelle à la sécurité des antipsychotiques chez l’enfant et l’adolescent Open
View article: PDL1 inhibitors may be associated with a lower risk of allograft rejection than PD1 and CTLA4 inhibitors: analysis of the WHO pharmacovigilance database
PDL1 inhibitors may be associated with a lower risk of allograft rejection than PD1 and CTLA4 inhibitors: analysis of the WHO pharmacovigilance database Open
Background Transplant recipients face increased cancer mortality due to immunosuppressive treatments. Immune checkpoint inhibitors (ICI) have improved survival rates, but data on the use of these agents in transplant recipients is scarce. …
View article: Couple and Sexuality vs. Smartphone: Who Wins? Impact of Smartphone Addiction on Marital and Sexual Satisfaction in Couples
Couple and Sexuality vs. Smartphone: Who Wins? Impact of Smartphone Addiction on Marital and Sexual Satisfaction in Couples Open
View article: Evaluating the implementation of a hypertension program based on mHealth and community pharmacies integration to primary care centers at a municipality level in Argentina during the COVID-19 pandemic
Evaluating the implementation of a hypertension program based on mHealth and community pharmacies integration to primary care centers at a municipality level in Argentina during the COVID-19 pandemic Open
Introduction While pharmacists-led interventions in hypertension have proven effective in high-income countries, their implementation and impact in low- and middle-income countries (LMIC) remain limited. This study assessed the implementat…
View article: Cardiac and metabolic safety profile of antipsychotics in youths: A WHO safety database analysis
Cardiac and metabolic safety profile of antipsychotics in youths: A WHO safety database analysis Open
View article: Optimization of Rituximab Therapy in Adult Patients With PLA2R1-Associated Membranous Nephropathy With Artificial Intelligence
Optimization of Rituximab Therapy in Adult Patients With PLA2R1-Associated Membranous Nephropathy With Artificial Intelligence Open
This algorithm could allow for early intensification of rituximab regimen in patients at high estimated risk of underdosing to increase the likelihood of remission.
View article: The Neuropsychiatric Safety Profile of Lasmiditan: A Comparative Disproportionality Analysis with Triptans
The Neuropsychiatric Safety Profile of Lasmiditan: A Comparative Disproportionality Analysis with Triptans Open
View article: Drug-related catatonia in youths: real-world insights from the WHO Safety Database
Drug-related catatonia in youths: real-world insights from the WHO Safety Database Open
Catatonia is characterized by psychomotor alterations and reduced contact with the environment. Initially linked to schizophrenia, it also occurs in mood disorders or organic conditions. In children, catatonia remains poorly delineated, de…
View article: CAR-T Cells and the Kidney: Insights from the WHO Safety Database
CAR-T Cells and the Kidney: Insights from the WHO Safety Database Open
This study is limited by the inherent flaws of pharmacovigilance approaches. Nonetheless, our findings suggest that ARF and an array of hydroelectrolytic disorders are potential ADRs of CAR-T cell therapy, in real-life settings and in a no…
View article: A Hplc-Dad Method Facilitates Large-Scale Monitoring of Dalbavancin
A Hplc-Dad Method Facilitates Large-Scale Monitoring of Dalbavancin Open
View article: Antipsychotic Abuse, Dependence, and Withdrawal in the Pediatric Population: A Real-World Disproportionality Analysis
Antipsychotic Abuse, Dependence, and Withdrawal in the Pediatric Population: A Real-World Disproportionality Analysis Open
Antipsychotic drugs (APs) aim to treat schizophrenia, bipolar mania, and behavioral symptoms. In child psychiatry, despite limited evidence regarding their efficacy and safety, APs are increasingly subject to off-label use. Studies investi…
View article: Drug-Associated Parosmia: New Perspectives from the WHO Safety Database
Drug-Associated Parosmia: New Perspectives from the WHO Safety Database Open
Parosmia is a qualitative distortion of smell perception. Resulting from central causes, sinonasal diseases, and infections, parosmia has also been associated with medications. Therefore, we aimed to investigate potential signals for drugs…
View article: New Strategies for Volume Control in Patients with Diabetes Mellitus, a Narrative Review
New Strategies for Volume Control in Patients with Diabetes Mellitus, a Narrative Review Open
Sodium is reabsorbed all along the renal tubules. The positive impacts of sodium-glucose cotransporter-2 inhibitors (SGLT2i), angiotensin receptor neprilysin inhibitor (ARNI) and mineralocorticoid receptor antagonists (MRA) on hard renal a…
View article: Medications as a Trigger of Sleep-Related Eating Disorder: A Disproportionality Analysis
Medications as a Trigger of Sleep-Related Eating Disorder: A Disproportionality Analysis Open
Sleep-related eating disorder (SRED) is a parasomnia with recurrent, involuntary, amnestic eating episodes during sleep. There is growing evidence of the association between SRED and medications. Therefore, we aimed to rank drugs showing t…
View article: Adverse Drug Reactions of Olanzapine, Clozapine and Loxapine in Children and Youth: A Systematic Pharmacogenetic Review
Adverse Drug Reactions of Olanzapine, Clozapine and Loxapine in Children and Youth: A Systematic Pharmacogenetic Review Open
Children and youth treated with antipsychotic drugs (APs) are particularly vulnerable to adverse drug reactions (ADRs) and prone to poor treatment response. In particular, interindividual variations in drug exposure can result from differe…
View article: COVID-19 Vaccine-Associated Transient Global Amnesia: A Disproportionality Analysis of the WHO Safety Database
COVID-19 Vaccine-Associated Transient Global Amnesia: A Disproportionality Analysis of the WHO Safety Database Open
Coronavirus disease 2019 (COVID-19) spread rapidly, resulting in a global pandemic for which vaccines were quickly developed. As their safety continues to be monitored, cases of transient global amnesia (TGA) following mRNA vaccination wit…
View article: Drug-Induced Tubulointerstitial Nephritis: Insights From the World Health Organization Safety Database
Drug-Induced Tubulointerstitial Nephritis: Insights From the World Health Organization Safety Database Open
Tubulointerstitial nephritis (TIN) is characterized by renal failure associated with an array of histologic lesions relating to an infiltration of inflammatory cells in the kidney interstitium with edema, often accompanied by tubulitis.1 T…
View article: Protocol: Adverse Drug Reactions of Olanzapine, Clozapine and Loxapine in Children and Youth: A Systematic Pharmacogenetic Review
Protocol: Adverse Drug Reactions of Olanzapine, Clozapine and Loxapine in Children and Youth: A Systematic Pharmacogenetic Review Open
Review question / Objective: In children and youth treated with olanzapine, clozapine, or loxapine and having undergone genotyping, which are the pharmacogenetic variants underlying the antipsychotics' adverse drug reactions and efficacy? …
View article: Calcitonin gene-related peptide-targeting drugs and Raynaud’s phenomenon: a real-world potential safety signal from the WHO pharmacovigilance database
Calcitonin gene-related peptide-targeting drugs and Raynaud’s phenomenon: a real-world potential safety signal from the WHO pharmacovigilance database Open
View article: Risk factors associated with immune checkpoint inhibitor–induced acute kidney injury compared with other immune-related adverse events: a case–control study
Risk factors associated with immune checkpoint inhibitor–induced acute kidney injury compared with other immune-related adverse events: a case–control study Open
Background Immune checkpoint inhibitors (ICIs) foster anti-cancer immune responses. Their efficacy comes at the cost of immune-related adverse events (IRAEs). The latter affects various organs, including kidneys, mostly as acute tubulointe…
View article: Case Report: Severe Hypercalcemia Following Vitamin D Intoxication in an Infant, the Underestimated Danger of Dietary Supplements
Case Report: Severe Hypercalcemia Following Vitamin D Intoxication in an Infant, the Underestimated Danger of Dietary Supplements Open
Vitamin D supplementation is routinely introduced in infants, according to medical guidelines. However, vitamin D overdose can result in life-threatening hypercalcemia. We report the case of a 3-month-old infant who suffered from severe hy…