Dali Han
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View article: Long Single‐Stranded DNA with Site‐Specific Modifications to Enable Single‐Base‐Resolution Epigenetics
Long Single‐Stranded DNA with Site‐Specific Modifications to Enable Single‐Base‐Resolution Epigenetics Open
We report a method for synthesizing site‐specifically modified long single‐stranded DNA (ssDNA) with high purity and fidelity. With the successful synthesis of long ssDNA carrying different 5‐methylcytosine (5mC) patterns, single‐base‐reso…
View article: SPP1 Drives Colorectal Cancer Liver Metastasis and Immunotherapy Resistance by Stimulating CXCL12 Production in Cancer-Associated Fibroblasts
SPP1 Drives Colorectal Cancer Liver Metastasis and Immunotherapy Resistance by Stimulating CXCL12 Production in Cancer-Associated Fibroblasts Open
Colorectal cancer remains a major cause of cancer-related morbidity and mortality globally, with 30% to 40% of cases developing metastasis, mainly to the liver. Although immunotherapy has shown promise for colorectal cancer treatment, pati…
View article: [Mediating effect of sleep duration between depression symptoms and myopia in middle school students].
[Mediating effect of sleep duration between depression symptoms and myopia in middle school students]. Open
Sleep duration serves as a partial mediator between depression symptoms and myopia in middle school students.
View article: The relationship between adolescent sleep duration and exposure to school bullying: the masking effect of depressive symptoms
The relationship between adolescent sleep duration and exposure to school bullying: the masking effect of depressive symptoms Open
Background Adolescents who suffer from school bullying are often accompanied by problems such as sleep disorders and depression. However, it remains unclear how depressive symptoms and sleep assessments such as sleep duration interact in t…
View article: Colonic stem cell from severe ulcerative colitis maintains environment-independent immune activation by altering chromatin accessibility and global m6A loss
Colonic stem cell from severe ulcerative colitis maintains environment-independent immune activation by altering chromatin accessibility and global m6A loss Open
Ulcerative colitis (UC) is a chronic inflammatory disease of colon, which is characterized by cryptarchitectural distortion. Alternation of colonic stem cell (CoSC) contributed to the occurrence of UC, yet the regulatory mechanisms remain …
View article: Role and mechanisms of noncoding RNAs in the regulation of metabolic reprogramming in bladder cancer (Review)
Role and mechanisms of noncoding RNAs in the regulation of metabolic reprogramming in bladder cancer (Review) Open
Bladder cancer (BLCA) is the most common type of urothelial cancer. The role of metabolic reprogramming in tumors is gradually gaining more attention and being investigated. Recent studies have shown that noncoding RNAs (ncRNAs) are strong…
View article: Cellular Composition and 5hmC Signature Predict the Treatment Response of AML Patients to Azacitidine Combined with Chemotherapy
Cellular Composition and 5hmC Signature Predict the Treatment Response of AML Patients to Azacitidine Combined with Chemotherapy Open
Azacitidine (AZA) is a DNA methyltransferase inhibitor and epigenetic modulator that can be an effective agent in combination with chemotherapy for patients with high‐risk acute myeloid leukemia (AML). However, biological factors driving t…
View article: Mettl3-m6A-Creb1 forms an intrinsic regulatory axis in maintaining iNKT cell pool and functional differentiation
Mettl3-m6A-Creb1 forms an intrinsic regulatory axis in maintaining iNKT cell pool and functional differentiation Open
N6-methyladenosine (m6A) methyltransferase Mettl3 is involved in conventional T cell immunity; however, its role in innate immune cells remains largely unknown. Here, we show that Mettl3 intrinsically regulates invariant natural killer T (…
View article: RNA Modification in the Immune System
RNA Modification in the Immune System Open
Characterization of RNA modifications has identified their distribution features and molecular functions. Dynamic changes in RNA modification on various forms of RNA are essential for the development and function of the immune system. In t…
View article: <scp>m<sup>6</sup>A</scp> promotes planarian regeneration
<span>m<sup>6</sup>A</span> promotes planarian regeneration Open
Regeneration is the regrowth of damaged tissues or organs, a vital process in response to damages from primitive organisms to higher mammals. Planarian possesses active whole‐body regenerative capability owing to its vast reservoir of adul…
View article: Status of the poor vision among primary and secondary school students in a division of Xinjiang Production and Construction Corps and analysis of the influencing factors
Status of the poor vision among primary and secondary school students in a division of Xinjiang Production and Construction Corps and analysis of the influencing factors Open
AIM: To understand the status of poor vision and analyze the main influencing factors among primary and secondary school students in a division of the Xinjiang Production and Construction Corps, and provide a scientific basis for preventio…
View article: Comparing the effect of modified ureterosigmoidostomy（MainzⅡ）in the treatment of bladder cancer after open and laparoscopic radical cystectomy
Comparing the effect of modified ureterosigmoidostomy（MainzⅡ）in the treatment of bladder cancer after open and laparoscopic radical cystectomy Open
Background To analyze perioperative conditions and long-term efficacy of open modified ureterosigmoidostomy urinary diversion (OMUUD) in patients with bladder cancer who underwent open radical cystectomy (ORC) or laparoscopic radical cyste…
View article: A Photo-triggered Wittig-Cyclization for Detecting and Sequencing 5-Formylcytidine in RNA
A Photo-triggered Wittig-Cyclization for Detecting and Sequencing 5-Formylcytidine in RNA Open
The simultaneous detection of a specific post-transcriptional modification that decorates the natural RNA can provide comprehensive information to better understand cellular and molecular functions of this variation. 5-Formylcytidine f5C i…
View article: AutoGenome: An AutoML tool for genomic research
AutoGenome: An AutoML tool for genomic research Open
Deep learning has achieved great successes in traditional fields like computer vision (CV), natural language processing (NLP), speech processing, and more. These advancements have greatly inspired researchers in genomics and made deep lear…
View article: Integrative analysis of immune molecular subtypes and microenvironment characteristics of bladder cancer
Integrative analysis of immune molecular subtypes and microenvironment characteristics of bladder cancer Open
The emergence of immunotherapy has provided an option of treatment methods for bladder cancer (BC). However, the beneficiaries of immunotherapy are still limited to small‐scale patients, and immunotherapy‐related adverse events often occur…
View article: The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR
The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR Open
On January 22, 2020, China National Center for Bioinformation (CNCB) released the 2019 Novel Coronavirus Resource (2019nCoVR), an open-access information resource for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2019nC…
View article: Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021
Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021 Open
The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a suite of database resources to support worldwide research activities in both academia and industry. With the explosive growth…
View article: The global landscape of SARS-CoV-2 genomes, variants, and haplotypes in 2019nCoVR
The global landscape of SARS-CoV-2 genomes, variants, and haplotypes in 2019nCoVR Open
On 22 January 2020, the National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), created the 2019 Novel Coronavirus Resource (2019nCoVR), an open-access SARS-CoV-2 information resource. 2019nCoVR f…
View article: Identification of prognostic biomarkers associated with stromal cell infiltration in muscle‐invasive bladder cancer by bioinformatics analyses
Identification of prognostic biomarkers associated with stromal cell infiltration in muscle‐invasive bladder cancer by bioinformatics analyses Open
Muscle‐invasive bladder cancer (MIBC) is one of the common malignant tumors. Patients with MIBC still have high tumor recurrence and progression rates after surgery. Bioinformatics analysis of stromal infiltration‐related genes in the tumo…
View article: Systemic <i>In Silico</i> Screening in Drug Discovery for Coronavirus Disease (COVID-19) with an Online Interactive Web Server
Systemic <i>In Silico</i> Screening in Drug Discovery for Coronavirus Disease (COVID-19) with an Online Interactive Web Server Open
The emergence of the new coronavirus (nCoV-19) has impacted human health on a global scale, while the interaction between the virus and the host is the foundation of the disease. The viral genome codes a cluster of proteins, each with a un…
View article: Effects and mechanisms of AMIGO2 in proliferation, migration and drug resistance of bladder cancer
Effects and mechanisms of AMIGO2 in proliferation, migration and drug resistance of bladder cancer Open
Background Bladder cancer is the most common malignancy in urinary system, but the therapeutic targets remain elusive. This study aims to reveal the relationship between AMIGO2 and proliferation, migration, drug-resistance and tumorigenici…
View article: Systemic in Silico Screening in Drug Discovery for Coronavirus Disease (COVID-19) with an Online Interactive Web Server
Systemic in Silico Screening in Drug Discovery for Coronavirus Disease (COVID-19) with an Online Interactive Web Server Open
The emergence of the new coronavirus (nCoV-19) has brought global impact on human health, whilst the interaction between the virus and the host is the foundation of the disease. The viral genome codes a cluster of proteins, each with a uni…
View article: <i>N</i> <sup>6</sup> -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
<i>N</i> <sup>6</sup> -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription Open
A new layer of transcriptional control N 6 -methyladenosine (m 6 A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m 6 A is also cotranscriptionally added onto various chromosome-associat…
View article: AutoGenome: An AutoML Tool for Genomic Research
AutoGenome: An AutoML Tool for Genomic Research Open
Deep learning have made great successes in traditional fields like computer vision (CV), natural language processing (NLP) and speech processing. Those achievements greatly inspire researchers in genomic study and make deep learning in gen…