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View article: Health security at genomic artificial intelligence–antimicrobial resistance frontiers in low-income countries
Health security at genomic artificial intelligence–antimicrobial resistance frontiers in low-income countries Open
View article: Balancing complexity and clarity—towards clinician-ready antibiotic resistance prediction models
Balancing complexity and clarity—towards clinician-ready antibiotic resistance prediction models Open
Motivation The escalating challenge of antibiotic resistance (ABR) demands clinician-ready machine learning models that are not only accurate but interpretable. Results By treating resistance genes as independent features and augmenting th…
View article: Genomic variations in Mycobacterium tuberculosis from the lungs and blood of HIV-infected individuals in Uganda: insights into compartmentalization
Genomic variations in Mycobacterium tuberculosis from the lungs and blood of HIV-infected individuals in Uganda: insights into compartmentalization Open
Mycobacterium tuberculosis (MTB) clinical strains are relatively varied at the genome level. This in-silico study analyzed genomic differences between MTB isolates from the blood and lungs of TB-HIV positive cohorts in Uganda. The hypothes…
View article: Evaluation of three protocols for direct susceptibility testing for gram negative-Enterobacteriaceae from patient samples in Uganda with SMS reporting
Evaluation of three protocols for direct susceptibility testing for gram negative-Enterobacteriaceae from patient samples in Uganda with SMS reporting Open
In Uganda, the challenge of generating and timely reporting essential antimicrobial resistance (AMR) data has led to overreliance on empirical antibiotic therapy, exacerbating the AMR crisis. To address this issue, this study aimed to adap…
View article: Enhancing genomics and bioinformatics access in Africa: an imperative leap
Enhancing genomics and bioinformatics access in Africa: an imperative leap Open
Despite the immense potential of genomics and bioinformatics in revolutionising public health in low-income countries (LICs) in Africa, their complete integration faces multiple obstacles. Among these obstacles, the scarcity of expertise, …
View article: Adherence to malaria treatment guidelines among health care workers in private health facilities in Kampala’s informal settlements, Uganda
Adherence to malaria treatment guidelines among health care workers in private health facilities in Kampala’s informal settlements, Uganda Open
Poor adherence to malaria treatment guidelines among healthcare workers (HCWs) is a major contribution to diagnostic challenges, treatment failure, and non-rational use of antimalarial medicines. However, there is limited information about…
View article: Isoniazid preventive therapy completion and factors associated with non-completion among patients on antiretroviral therapy at Kisenyi Health Centre IV, Kampala, Uganda
Isoniazid preventive therapy completion and factors associated with non-completion among patients on antiretroviral therapy at Kisenyi Health Centre IV, Kampala, Uganda Open
Background Isoniazid preventive therapy (IPT) is given to HIV patients to reduce the risk of active tuberculosis (TB). However, treatment completion remains suboptimal among those that are initiated. This study aimed to determine the compl…
View article: Investigating the evolution and predicting the future outlook of antimicrobial resistance in sub-saharan Africa using phenotypic data for Klebsiella pneumoniae: a 12-year analysis
Investigating the evolution and predicting the future outlook of antimicrobial resistance in sub-saharan Africa using phenotypic data for Klebsiella pneumoniae: a 12-year analysis Open
View article: Source-tracking ESBL-producing bacteria at the maternity ward of Mulago hospital, Uganda
Source-tracking ESBL-producing bacteria at the maternity ward of Mulago hospital, Uganda Open
Introduction Escherichia coli , Klebsiella pneumoniae and Enterobacter (EKE) are the leading cause of mortality and morbidity in neonates in Africa. The management of EKE infections remains challenging given the global emergence of carbape…
View article: Isoniazid preventive therapy completion and factors associated with non-completion among patients on antiretroviral therapy at Kisenyi Health Centre IV, Kampala, Uganda
Isoniazid preventive therapy completion and factors associated with non-completion among patients on antiretroviral therapy at Kisenyi Health Centre IV, Kampala, Uganda Open
Background Isoniazid preventive therapy (IPT) is given to HIV patients to reduce the risk of active tuberculosis (TB). However, treatment completion remains sub-optimal among those that are initiated. This study aimed to determine the comp…
View article: Medically important bacteria isolated from commercial herbal medicines in Kampala city indicate the need to enhance safety frameworks
Medically important bacteria isolated from commercial herbal medicines in Kampala city indicate the need to enhance safety frameworks Open
View article: Extending political will into action in African LMICs: abating global antimicrobial resistance
Extending political will into action in African LMICs: abating global antimicrobial resistance Open
Antimicrobial resistance remains a threat to human health globally.1Antimicrobial Resistance CollaboratorsGlobal burden of bacterial antimicrobial resistance in 2019: a systematic analysis.Lancet. 2022; 399: 629-655Summary Full Text Full T…
View article: Global evidence on the potential of some Ugandan herbal medicines to mitigate antibiotic resistance: a systematic review and meta-analysis from 1996 to 2021
Global evidence on the potential of some Ugandan herbal medicines to mitigate antibiotic resistance: a systematic review and meta-analysis from 1996 to 2021 Open
Background Diarrheal and respiratory ailments are major causes of global deaths, and are mostly escalated by antibiotic-resistant bacteria (ARB), warranting novel therapies against ARB. In Uganda, plants like C. pyrrhopappa, E. abyssinica,…
View article: The need to improve antimicrobial susceptibility testing capacity in Ugandan health facilities: insights from a surveillance primer
The need to improve antimicrobial susceptibility testing capacity in Ugandan health facilities: insights from a surveillance primer Open
View article: Antibiotic-resistance in medically important bacteria isolated from commercial herbal medicines in Africa from 2000 to 2021: a systematic review and meta-analysis
Antibiotic-resistance in medically important bacteria isolated from commercial herbal medicines in Africa from 2000 to 2021: a systematic review and meta-analysis Open
Background Antimicrobial resistance is swiftly increasing all over the world. In Africa, it manifests more in pathogenic bacteria in form of antibiotic resistance (ABR). On this continent, bacterial contamination of commonly used herbal me…
View article: Transmission Dynamics of Antimicrobial Resistance at a National Referral Hospital in Uganda
Transmission Dynamics of Antimicrobial Resistance at a National Referral Hospital in Uganda Open
Reliable data on antimicrobial resistance (AMR) transmission dynamics in Uganda remains scarce; hence, we studied this area. Eighty-six index patients and “others” were recruited. Index patients were those who had been admitted to the orth…
View article: Increasing Antimicrobial Resistance in Surgical Wards at Mulago National Referral Hospital, Uganda, from 2014 to 2018—Cause for Concern?
Increasing Antimicrobial Resistance in Surgical Wards at Mulago National Referral Hospital, Uganda, from 2014 to 2018—Cause for Concern? Open
Antimicrobial Resistance (AMR) and Healthcare Associated Infections (HAIs) are major global public health challenges in our time. This study provides a broader and updated overview of AMR trends in surgical wards of Mulago National Referra…
View article: Demystifying media sources of information and levels of knowledge about COVID-19: a rapid mini-review of cross-sectional studies in Africa
Demystifying media sources of information and levels of knowledge about COVID-19: a rapid mini-review of cross-sectional studies in Africa Open
COVID-19 control is highly affected by knowledge levels which are also affected by receipt of information on the disease. Therefore, this review examined knowledge levels and media sources of information findings of the studies on knowledg…
View article: Gastrointestinal Tract Colonization Rate of Extended-Spectrum Beta-Lactamase-Producing Gram-Negative Bacteria and Associated Factors Among Orthopaedic Patients in a Tertiary Hospital in Tanzania: Implications for Infection Prevention
Gastrointestinal Tract Colonization Rate of Extended-Spectrum Beta-Lactamase-Producing Gram-Negative Bacteria and Associated Factors Among Orthopaedic Patients in a Tertiary Hospital in Tanzania: Implications for Infection Prevention Open
We found a high occurrence of ESBL colonization among participants and in the environmentat this tertiary hospital. The importance of routine ESBL surveillance among orthopaedic patients with open fractures on admission and strengthened de…
View article: Efficacy of Face Masks Used in Uganda: A Laboratory-Based Inquiry during the COVID-19 Pandemic
Efficacy of Face Masks Used in Uganda: A Laboratory-Based Inquiry during the COVID-19 Pandemic Open
With shortages of face masks being reported worldwide, it is critical to consider alternatives to commercially manufactured face masks. This study aimed to test and compare the efficacy of various makes of locally made or homemade cloth fa…
View article: Genomics and bioinformatics capacity in Africa: no continent is left behind
Genomics and bioinformatics capacity in Africa: no continent is left behind Open
Despite the poor genomics research capacity in Africa, efforts have been made to empower African scientists to get involved in genomics research, particularly that involving African populations. As part of the Human Heredity and Health in …
View article: Publishing research - demystifying the course
Publishing research - demystifying the course Open
Over the years, numerous research projects reacting to an array of scientific questions have been pursued and most have been accomplished. However, despite the existence of several accredited, open-access- peer- reviewed- scientific journa…
View article: Face-Masking, an Acceptable Protective Measure against COVID-19 in Ugandan High-Risk Groups
Face-Masking, an Acceptable Protective Measure against COVID-19 in Ugandan High-Risk Groups Open
Face-masking could reduce the risk of COVID-19 transmission. We assessed knowledge, attitudes, perceptions, and practices toward COVID-19 and face-mask use among 644 high-risk individuals in Kampala, Uganda. In data analysis, descriptive, …
View article: Review of phenotypic assays for detection of extended-spectrum β-lactamases and carbapenemases: a microbiology laboratory bench guide
Review of phenotypic assays for detection of extended-spectrum β-lactamases and carbapenemases: a microbiology laboratory bench guide Open
Background: Infections caused by gram-negative antibiotic-resistant bacteria continue to increase. Despite recommenda- tions by the Clinical Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility T…
View article: Efficacy of face-masks used in Uganda: a laboratory-based inquiry during the COVID-19 pandemic
Efficacy of face-masks used in Uganda: a laboratory-based inquiry during the COVID-19 pandemic Open
Background With shortages of face-masks continuing to be reported worldwide, critical questions like whether or not there is an adequate alternative to commercially manufactured face-masks continue to linger especially in low- and middle-i…
View article: Face-masking, an acceptable protective measure against COVID-19 - Findings of Ugandan high-risk groups
Face-masking, an acceptable protective measure against COVID-19 - Findings of Ugandan high-risk groups Open
Face-masking could reduce the risk of COVID-19 transmission. We assessed: knowledge, attitudes, perceptions, and practices towards COVID-19 and face-mask use among 644 high risk-individuals in Kampala, Uganda. In data analysis, descriptive…
View article: High Prevalence of Antibiotic Resistant Escherichia coli Serotype O157: H7 among Pastoral Communities in Rural Uganda
High Prevalence of Antibiotic Resistant Escherichia coli Serotype O157: H7 among Pastoral Communities in Rural Uganda Open
Background: Non-prescribed use of antimicrobials in Agriculture incurs a transfer risk of resistant pathogens to humans, complicating treatment. The aim of this study was to determine the potential of Zoonotic E. coli to serve as drivers o…
View article: Whole-genome sequence analysis reveals evolution of antimicrobial resistance in a Ugandan colistin resistant<i>Acinetobacter baumannii</i>
Whole-genome sequence analysis reveals evolution of antimicrobial resistance in a Ugandan colistin resistant<i>Acinetobacter baumannii</i> Open
In recent times, pan-drug resistant Acinetobacter baumannii have emerged and continue to spread among critically ill patients, this poses an urgent risk to global and local human health. This study sought to provide the first genomic analy…
View article: EFFICACY OF FACE-MASKS USED IN UGANDA: A LABORATORY-BASED INQUIRY DURING THE COVID-19 PANDEMIC-DATASET
EFFICACY OF FACE-MASKS USED IN UGANDA: A LABORATORY-BASED INQUIRY DURING THE COVID-19 PANDEMIC-DATASET Open
Dataset analysed in the study: EFFICACY OF FACE-MASKS USED IN UGANDA: A LABORATORY-BASED INQUIRY DURING THE COVID-19 PANDEMIC
View article: blaVIM- and blaOXA-mediated carbapenem resistance among Acinetobacter baumannii and Pseudomonas aeruginosa isolates from the Mulago hospital intensive care unit in Kampala, Uganda
blaVIM- and blaOXA-mediated carbapenem resistance among Acinetobacter baumannii and Pseudomonas aeruginosa isolates from the Mulago hospital intensive care unit in Kampala, Uganda Open