Didi Geng
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View article: O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular matrix to facilitate tumor growth
O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular matrix to facilitate tumor growth Open
The tumor microenvironment is an immunosuppressive niche that contributes to tumor growth by downregulating immune cell functions or restraining immune cell infiltration. The underlying mechanisms are not still poorly understood. Here, we …
View article: A Computational and Chemical Design Strategy for Manipulating Glycan‐Protein Recognition
A Computational and Chemical Design Strategy for Manipulating Glycan‐Protein Recognition Open
Glycans are complex biomolecules that encode rich information and regulate various biological processes, such as fertilization, host‐pathogen binding, and immune recognition, through interactions with glycan‐binding proteins. A key driving…
View article: Liver cancer heterogeneity modeled by in situ genome editing of hepatocytes
Liver cancer heterogeneity modeled by in situ genome editing of hepatocytes Open
Mechanistic study and precision treatment of primary liver cancer (PLC) are hindered by marked heterogeneity, which is challenging to recapitulate in any given liver cancer mouse model. Here, we report the generation of 25 mouse models of …
View article: O-GlcNAcylation regulates epidermal growth factor receptor intracellular trafficking and signaling
O-GlcNAcylation regulates epidermal growth factor receptor intracellular trafficking and signaling Open
Significance Epidermal growth factor receptor (EGFR) is one of the most important membrane receptors that transduce growth signals into cells to sustain cell growth, proliferation, and survival. EGFR signal termination is initiated by EGFR…
View article: The mTORC1‐eIF4F axis controls paused pluripotency
The mTORC1‐eIF4F axis controls paused pluripotency Open