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Determinants of renal flow reserve in adult patients with and without renal artery stenosis Open
Renal flow reserve (RFR) is a hemodynamic measure of renal microvascular function and may help identify patients with renal artery stenosis (RAS) who could benefit from revascularization. Reference ranges and clinical correlates of RFR in …
View article: Cardiovascular Risk Factors Impact Brain Volume and White Matter Hyperintensities: A Multiethnic Cohort Study
Cardiovascular Risk Factors Impact Brain Volume and White Matter Hyperintensities: A Multiethnic Cohort Study Open
Background and Purpose Brain atrophy and white matter hyperintensities (WMHs) are established markers of cerebrovascular disease, yet most evidence comes from older populations of predominantly European descent. We prospectively examined t…
View article: Impaired autonomic cardiovascular control in people with HIV on long-term successful treatment
Impaired autonomic cardiovascular control in people with HIV on long-term successful treatment Open
Objective: People with HIV have an increased cardiovascular disease risk. Persistent inflammation and mitochondrial dysfunction are considered important contributors to impaired autonomic cardiovascular control, as evidenced by decreased b…
View article: Autonomic cardiac control independently predicts incident hypertension and systolic blood pressure in a multi-ethnic population: the HELIUS study
Autonomic cardiac control independently predicts incident hypertension and systolic blood pressure in a multi-ethnic population: the HELIUS study Open
Aims Cross-correlation baroreflex sensitivity (xBRS) and heart rate variability (HRV) are measures of autonomic cardiac control and are associated with hypertension. However, their value in predicting new-onset hypertension and changes in …
View article: Mid-life association between cardiovascular risk factors and cerebral blood flow in a multi-ethnic population
Mid-life association between cardiovascular risk factors and cerebral blood flow in a multi-ethnic population Open
Background Cardiovascular (CV) risk factors are associated with cerebrovascular damage and cognitive decline in late life. However, it is unknown how different ethnic CV risk profiles are related to cerebral haemodynamics in mid-life. We a…
View article: Effects of Oral Butyrate on Blood Pressure in Patients With Hypertension: A Randomized, Placebo-Controlled Trial
Effects of Oral Butyrate on Blood Pressure in Patients With Hypertension: A Randomized, Placebo-Controlled Trial Open
BACKGROUND: The microbiota-derived short chain fatty acid butyrate has been shown to lower blood pressure (BP) in rodent studies. Nonetheless, the net effect of butyrate on hypertension in humans remains uncovered. In this study, for the f…
Oral Anaerobutyricum soehngenii augments glycemic control in type 2 diabetes Open
This randomized, double-blind, placebo-controlled trial investigated the impact of 14-day Anaerobutyricum soehngenii L2-7 supplementation on postprandial glucose levels in 25 White Dutch males with type 2 diabetes (T2D) on stable metformin…
View article: Sex differences in blood pressure phenotypes over time – the HELIUS study
Sex differences in blood pressure phenotypes over time – the HELIUS study Open
Background: Hypertension can be classified into different phenotypes according to systolic and diastolic blood pressure (BP). In younger adults, these phenotypical differences have different prognostic value for men and women. However, lit…
View article: Ethnic Differences in Carotid Intima-Media Thickness and Plaque Presence: The HELIUS Study
Ethnic Differences in Carotid Intima-Media Thickness and Plaque Presence: The HELIUS Study Open
Introduction: In the Netherlands, the prevalence of cardiovascular diseases (CVDs) is higher among South-Asian Surinamese and lower among Moroccans compared to the Dutch. Traditional risk factors for atherosclerotic CVD do not fully explai…
View article: Comparative Analysis of Taxonomic and Functional Gut Microbiota Profiles in Relation to Seroconversion of Thyroid Peroxidase Antibodies in Euthyroid Participants
Comparative Analysis of Taxonomic and Functional Gut Microbiota Profiles in Relation to Seroconversion of Thyroid Peroxidase Antibodies in Euthyroid Participants Open
Background: Previous studies have reported gut microbiome alterations in Hashimoto's autoimmune thyroiditis (HT) patients. Yet, it is unknown whether an aberrant microbiome is present before clinical disease onset in participants susceptib…
Association Between Self‐Rated Medication Adherence and Adverse Cardiovascular Outcomes in Patients With Hypertension Open
Background Medication nonadherence contributes to poor health outcomes but remains challenging to identify. This study assessed the association between self‐rated adherence and systolic blood pressure, low‐density lipoprotein cholesterol l…
View article: Autonomic regulation in different hypertensive phenotypes - the HELIUS study
Autonomic regulation in different hypertensive phenotypes - the HELIUS study Open
Background: Hypertension can be classified into different phenotypes based on systolic and diastolic blood pressure (BP) that carry a different prognosis and may therefore be differently associated with sympathetic activity. We assessed th…
Assessment of renal sympathetic control using invasive pressure and flow velocity measurements in humans Open
Renal sympathetic innervation is important in the homeostasis of systemic and renal hemodynamics. We showed that renal arterial pressure significantly increased and that flow decreased during static handgrip exercise using direct renal art…
Sex differences in associations of plasma metabolites with blood pressure and heart rate variability: The HELIUS study Open
Plasma metabolite profiles are associated with BP in a sex-specific manner. Catecholamine derivatives were more important predictors for BP in women, while sphingomyelins were more important in men. Several metabolites were associated with…
Ethnic differences in blood pressure levels over time: the HELIUS study Open
Aims Hypertension is an important global health burden with major differences in prevalence among ethnic minorities compared with host populations. Longitudinal research on ethnic differences in blood pressure (BP) levels provides the oppo…
Supplementary Material for: Ethnic Differences in Carotid Intima Media Thickness and Plaque Presence - The HELIUS study Open
Introduction In the Netherlands, the prevalence of cardiovascular diseases (CVD) is higher among South-Asian Surinamese and lower among Moroccans compared to the Dutch. Traditional risk factors for atherosclerotic CVD do not fully explain …
Supplementary Material for: Ethnic Differences in Carotid Intima Media Thickness and Plaque Presence - The HELIUS study Open
Introduction In the Netherlands, the prevalence of cardiovascular diseases (CVD) is higher among South-Asian Surinamese and lower among Moroccans compared to the Dutch. Traditional risk factors for atherosclerotic CVD do not fully explain …
Association between the reflection magnitude and blood pressure in a multiethnic cohort: the Healthy Life in an Urban Setting study Open
Aims: Reflection magnitude (RM), the ratio of the amplitudes of the backward and forward central arterial pressure waves, has been shown to predict cardiovascular events. However, the association with blood pressure (BP) and hypertension i…
HERA3 STUDY: CAN PRESSURE-FLOW MEASUREMENTS AND COMPUTATIONAL FLOW SIMULATIONS GUIDE US WHEN TO TREAT RENAL ARTERY STENOSIS? Open
Objective: To stent or not to stent remains a difficult decision in patients with renal artery stenosis (RAS). Up to date, no diagnostic test that reliably identifies patients that will benefit from endovascular intervention has been estab…
SALT-SENSITIVITY IN HEALTHY NORMOTENSIVE MEN IS ASSOCIATED WITH IMPAIRED BAROREFLEX SENSITIVITY Open
Objective: Blood pressure (BP) responses to Na+ intake show great variability, discriminating sodium sensitive (SS) from salt resistant (SR) individuals. The pathophysiology behind salt-sensitivity is still not fully elucidated. A pivotal …
ASSOCIATIONS BETWEEN PLASMA METABOLOMICS AND BLOOD PRESSURE ACROSS ETHNICITIES: THE HELIUS STUDY Open
Objective: Blood pressure (BP) is regulated by plasma metabolites from different neurohumoral and cardiometabolic systems. Since there are well-established differences in hypertension pathogenesis and treatment response between ethnicities…
ASSOCIATION BETWEEN THE REFLECTION MAGNITUDE AND BLOOD-PRESSURE IN A MULTI-ETHNIC COHORT: THE HELIUS STUDY Open
Objective: The reflection magnitude (RM), the ratio of the amplitudes of the backward and forward central arterial pressure waves, has been shown to be predictive for future cardiovascular events, but the association between blood pressure…
PRELIMINARY REPORT: BLOOD PRESSURE TRAJECTORIES OVER TIME IN A MULTI-ETHNIC POPULATION Open
Objective: Objective: Hypertension remains the leading cause of cardiovascular diseases worldwide. Major interethnic differences in the prevalence of hypertension exist. Exploring blood pressure (BP) levels in a large prospective multi-eth…
ASSESSMENT OF RENAL SYMPATHETIC CONTROL USING INVASIVE PRESSURE AND FLOW VELOCITY MEASUREMENTS IN HUMANS Open
Objective: Renal sympathetic innervation is important in the control of renal and systemic hemodynamics and a target for pharmacological and catheter-based therapies. The effect of a physiological sympathetic stimulus using static handgrip…
Ethnic Differences in Coronavirus Disease 2019 Hospitalization and Hospital Outcomes in a Multiethnic Population in the Netherlands Open
Background Evidence from the United States and United Kingdom suggests that ethnic minority populations are at an increased risk for developing severe coronavirus disease 2019 (COVID-19); however, data from other West-European countries ar…
COVID-19 Impacts Across Multiple Life Domains of Vulnerable Socio-Demographic Groups Including Migrants: A Descriptive Cross-Sectional Study Open
Objectives: We assessed the impacts of COVID-19 on multiple life domains across socio-demographic groups in Netherlands. Methods: After the first COVID-19 wave, we distributed online questionnaires among 13,031 participants of the multi-et…