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View article: Identification of a lipid oxygen radical defense pathway and its epigenetic control
Identification of a lipid oxygen radical defense pathway and its epigenetic control Open
Membrane phospholipids are vulnerable to oxidative radicals, and uncontrolled lipid peroxidation affects cell viability. Cells have evolved quality control and defense mechanisms, of which the genetic regulation is not fully understood. He…
View article: A global survey of taxa-metabolic associations across mouse microbiome communities
A global survey of taxa-metabolic associations across mouse microbiome communities Open
Host-microbiota mutualism is rooted in the exchange of dietary and metabolic molecules. Microbial diversity broadens the metabolite pool, with each taxon contributing distinct compounds in varying proportions. In the human microbiome, high…
View article: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B
Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B Open
ZNF93 is a primate-restricted Krüppel-associated box zinc finger protein responsible for repressing 20- to 12-My-old L1 transposable elements. Here, we reveal that ZNF93 also regulates the key cancer driver APOBEC3B—a mutagenic enzyme link…
View article: Identification of the Lipid Oxygen Radical Defense pathway and its epigenetic control
Identification of the Lipid Oxygen Radical Defense pathway and its epigenetic control Open
Membrane phospholipids are vulnerable to oxidative radicals, and uncontrolled lipid peroxidation affects cell viability. Cells have evolved quality control and defense mechanisms, of which the genetic regulation of is not fully understood.…
View article: Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity
Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity Open
Transposable elements (TEs) have extensively reshaped the cis -regulatory landscape of mammalian genomes, yet the mechanisms that govern their context-specific activity remain incompletely understood. KRAB zinc finger proteins (KZFPs), a l…
View article: Transposable element co-option drives transcription factor neofunctionalization
Transposable element co-option drives transcription factor neofunctionalization Open
Gene duplication and domain acquisition are key mechanisms driving protein diversification. However, the impact of these processes on the function and evolution of transcription factors (TFs) remains poorly characterized. Here, we show tha…
View article: Zinc-finger proteins with a co-opted capsid domain anchor nucleosomes over transposon sequences
Zinc-finger proteins with a co-opted capsid domain anchor nucleosomes over transposon sequences Open
Transposable elements (TEs) are frequently co-opted as cis -regulatory sequences that govern multiple aspects of host biology. The regulatory activity of these domesticated sequences are controlled by host factors, notably KRAB domain-cont…
View article: Identification of a Lipid Oxygen Radical Defense pathway and its epigenetic control
Identification of a Lipid Oxygen Radical Defense pathway and its epigenetic control Open
Membrane phospholipids are vulnerable to oxidative radicals, and uncontrolled lipid peroxidation affects cell viability. Cells have evolved quality control and defense mechanisms, of which the genetic regulation is not fully understood. He…
View article: Evolutionarily recent transcription factors partake in human cell cycle regulation
Evolutionarily recent transcription factors partake in human cell cycle regulation Open
The cell cycle is a fundamental process in eukaryotic biology and is accordingly controlled by a highly conserved core signaling cascade. However, whether recently evolved proteins also influence this process is unclear. Here, we systemati…
View article: Single-cell transcriptome analysis reveals atypical monocytes circulating ahead of acute graft-versus-host disease clinical onset
Single-cell transcriptome analysis reveals atypical monocytes circulating ahead of acute graft-versus-host disease clinical onset Open
Acute graft-versus-host disease (aGVHD) represents the rejection of the recipient's skin, gut, and liver tissues of an allogeneic hematopoietic stem cell transplantation (HSCT) by the donor T cells. The onset of aGVHD is often rapid and it…
View article: Clusters of lineage-specific genes are anchored by ZNF274 in repressive perinucleolar compartments
Clusters of lineage-specific genes are anchored by ZNF274 in repressive perinucleolar compartments Open
Long known as the site of ribosome biogenesis, the nucleolus is increasingly recognized for its role in shaping three-dimensional (3D) genome organization. Still, the mechanisms governing the targeting of selected regions of the genome to …
View article: Insights into household transmission of SARS-CoV-2 from a population-based serological survey
Insights into household transmission of SARS-CoV-2 from a population-based serological survey Open
Understanding the risk of infection from household- and community-exposures and the transmissibility of asymptomatic infections is critical to SARS-CoV-2 control. Limited previous evidence is based primarily on virologic testing, which dis…
View article: Figure S5 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Figure S5 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Related to Figure 5: ZNF587/417 depletion triggers replicative stress in lymphoma cells.
View article: Data from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Data from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Heterochromatin loss and genetic instability enhance cancer progression by favoring clonal diversity, yet uncontrolled replicative stress leads to mitotic catastrophe and inflammatory responses that promote immune rejection. KRAB domain-co…
View article: Figure S4 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Figure S4 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Related to Figure 4: ZNF587/417 depletion alters the heterochromatin landscape of lymphoma cells.
View article: Data from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Data from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Heterochromatin loss and genetic instability enhance cancer progression by favoring clonal diversity, yet uncontrolled replicative stress leads to mitotic catastrophe and inflammatory responses that promote immune rejection. KRAB domain-co…
View article: Figure S3 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Figure S3 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Related to Figure 3: ZNF587/417 depletion impairs lymphoma cell growth and viability.
View article: Figure S3 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Figure S3 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Related to Figure 3: ZNF587/417 depletion impairs lymphoma cell growth and viability.
View article: Figure S6 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Figure S6 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Related to Figure 6: ZNF587/417 depletion leads to cell-intrinsic inflammation.
View article: Figure S5 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Figure S5 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Related to Figure 5: ZNF587/417 depletion triggers replicative stress in lymphoma cells.
View article: Figure S6 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Figure S6 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Related to Figure 6: ZNF587/417 depletion leads to cell-intrinsic inflammation.
View article: Figure S4 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Figure S4 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Related to Figure 4: ZNF587/417 depletion alters the heterochromatin landscape of lymphoma cells.
View article: Figure S2 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Figure S2 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Related to Figure 2: A module of KZFP genes in DLBCLs with cell-autonomous growth features.
View article: Figure S2 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Figure S2 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Related to Figure 2: A module of KZFP genes in DLBCLs with cell-autonomous growth features.
View article: Figure S1 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Figure S1 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Related to Figure 1: A KZFP gene cluster as poor prognosis predictor in DLBCL.
View article: Figure S1 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Figure S1 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Related to Figure 1: A KZFP gene cluster as poor prognosis predictor in DLBCL.
View article: A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation Open
Heterochromatin loss and genetic instability enhance cancer progression by favoring clonal diversity, yet uncontrolled replicative stress leads to mitotic catastrophe and inflammatory responses that promote immune rejection. KRAB domain-co…
View article: Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants
Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants Open
Growing evidence indicates that transposable elements (TEs) play important roles in evolution by providing genomes with coding and non-coding sequences. Identification of TE-derived functional elements, however, has relied on TE annotation…