Didik Setyo Heriyanto
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View article: Increasing quantitative estrogen receptor beta expression in meningioma after exogenous hormonal contraception exposure
Increasing quantitative estrogen receptor beta expression in meningioma after exogenous hormonal contraception exposure Open
Factors influencing estrogen receptor (ER) and progesterone receptor (PR) expression in meningioma are unclear. This study aimed to assess the expression of ER and PR in females with meningioma in relation to patient exogenous hormonal exp…
View article: Whole-Genome Sequencing Reveals a Novel GATA2 Mutation in Lower-Grade Glioma: Bioinformatics Analysis of Functional and Therapeutic Implications
Whole-Genome Sequencing Reveals a Novel GATA2 Mutation in Lower-Grade Glioma: Bioinformatics Analysis of Functional and Therapeutic Implications Open
Background/Objectives: Lower-grade gliomas, particularly IDH-mutant astrocytomas, represent a distinct molecular subtype with unique therapeutic challenges. Whole-genome sequencing (WGS) plays a crucial role in uncovering genetic alteratio…
View article: EVALUATING PERFORMANCE OF COMBINED HEMOGLOBIN AND TRANSFERRIN DETECTION IN FECAL IMMUNOCHEMICAL TESTING FOR COLORECTAL NEOPLASIA
EVALUATING PERFORMANCE OF COMBINED HEMOGLOBIN AND TRANSFERRIN DETECTION IN FECAL IMMUNOCHEMICAL TESTING FOR COLORECTAL NEOPLASIA Open
Background. Evidence-based screening strategies can substantially reduce colorectal cancer (CRC) mortality. While colonoscopy is the gold standard, its invasiveness renders it less preferable as an initial screening tool. A two-step approa…
View article: Selection of targeted therapy in a patient with non-small-cell lung adenocarcinoma and multiple driver mutations
Selection of targeted therapy in a patient with non-small-cell lung adenocarcinoma and multiple driver mutations Open
Lung cancer remains the leading cause of cancer-related mortality, with non-small-cell lung cancer (NSCLC) as the predominant type. Adenocarcinoma is the most frequent subtype, especially among non-smokers. Advances in molecular profiling …
View article: EGFR exon 19 mutations in metastatic rectal cancer to the lung: implications for diagnosis and treatment
EGFR exon 19 mutations in metastatic rectal cancer to the lung: implications for diagnosis and treatment Open
Epidermal growth factor receptor (EGFR) mutations are rare in colorectal cancer (CRC), with an incidence of approximately 2–3%, in contrast to non-small cell lung cancer (NSCLC), where EGFR mutations are more common and routinely treated w…
View article: Bronchial squamous cell papilloma incidental finding in bronchoscopy following prolonged ventilator weaning: A case report
Bronchial squamous cell papilloma incidental finding in bronchoscopy following prolonged ventilator weaning: A case report Open
Bronchial squamous cell papilloma (BSCP) is an uncommon tumor seen in the bronchi, while squamous cell papillomas are frequently observed in different organs. The fortuitous detection of BSCP underscores the significance of comprehensive d…
View article: ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells
ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells Open
Background Metals in particulate matter (PM), like iron (Fe), were associated with lung injury. Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) was suggested to inhibit lung inflammation. However, the effect of metals in PM, particula…
View article: High frequency of the PIK3CA H1047L mutation in Indonesian breast cancer across molecular subtypes
High frequency of the PIK3CA H1047L mutation in Indonesian breast cancer across molecular subtypes Open
Breast cancer (BC) is a global health concern with significant mortality rates, necessitating a deep understanding of its molecular landscape. Luminal A and B BC, characterized by estrogen receptor (ER) and/or progesterone receptor (PR) po…
View article: Spectrum of rare EGFR mutations in Indonesian lung adenocarcinoma: Findings from an 8-year analysis of 4,778 cases highlighting the need for advanced targeted therapies
Spectrum of rare EGFR mutations in Indonesian lung adenocarcinoma: Findings from an 8-year analysis of 4,778 cases highlighting the need for advanced targeted therapies Open
Lung cancer patients in Indonesia exhibit a high prevalence of epidermal growth factor receptor (EGFR) mutations, with a substantial proportion attributed to rare or uncommon variants. The clinical significance of rare EGFR mutations lies …
View article: The Effect of Manilkara Zapota L on The Histopathological Gastric Induced by Absolute Ethanol
The Effect of Manilkara Zapota L on The Histopathological Gastric Induced by Absolute Ethanol Open
Background: Gastric ulcers are a significant health issue caused by various factors, including excessive alcohol consumption. Manilkara zapota (M. zapota) has been reported to exhibit anti-inflammatory and antioxidant properties, which may…
View article: Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis
Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis Open
Background: Telomere length is a potential prognostic biomarker in breast cancer, but its clinical utility remains uncertain due to inconsistent findings across the literature. This systematic review and meta-analysis aims to evaluate the …
View article: Non-targeted effects of stereotactic radiotherapy: a review of the evidence coming from the clinical field
Non-targeted effects of stereotactic radiotherapy: a review of the evidence coming from the clinical field Open
Background: Preclinical animal studies have demonstrated that radiation treatment (RT) can induce effects beyond the anatomical site of irradiation. Non-targeted effects of RT (NTER) have been sporadically reported in clinical settings. Ho…
View article: The correlation between the expression of androgen receptor splice variant-7 (AR-V7) protein with the time of occurrence of castration-resistant prostate cancer and overall survival in prostate cancer in Indonesian population
The correlation between the expression of androgen receptor splice variant-7 (AR-V7) protein with the time of occurrence of castration-resistant prostate cancer and overall survival in prostate cancer in Indonesian population Open
Introduction Prostate cancer follows a natural trajectory characterized by genetic alterations that transform initially hormone-sensitive cancer cells into castration-resistant prostate cancer (CRPC), which is associated with high mortalit…
View article: Research trends in microRNA profiling as a biomarker for lung adenocarcinoma via liquid biopsy: A bibliometric analysis
Research trends in microRNA profiling as a biomarker for lung adenocarcinoma via liquid biopsy: A bibliometric analysis Open
Research related to the development of diagnostic biomarkers in lung adenocarcinoma in various countries is important. Research on microRNA as a biomarker in lung adenocarcinoma varies depending on the population, specimen, and technology …
View article: Prognosis value of circulating telomere repeat binding factor 2 and leukocyte telomere length in breast cancer mortality
Prognosis value of circulating telomere repeat binding factor 2 and leukocyte telomere length in breast cancer mortality Open
Telomere repeat binding factor 2 (TRF2) is currently a novel tumor marker, yet its clinical implication has not been investigated. The aim of this study was to investigate the prognostic value of circulating TRF2 and leukocyte telomere len…
View article: Long non-coding RNAs as prognostic biomarkers in non-muscle invasive bladder cancer: A systematic review
Long non-coding RNAs as prognostic biomarkers in non-muscle invasive bladder cancer: A systematic review Open
Traditional prognostic tools for non-muscle invasive bladder cancer (NMIBC) often overestimate progression and recurrence risks, underscoring the need for more precise biomarkers. While long non-coding ribonucleic acids (lncRNAs) have been…
View article: Eosinophilic inflammation: a key player in COPD pathogenesis and progression
Eosinophilic inflammation: a key player in COPD pathogenesis and progression Open
Understanding eosinophilic involvement in COPD can facilitate the development of precision medicine approaches, offering more tailored and effective treatment options. Future research should continue to focus on the integration of eosinoph…
View article: Resilience in Healthcare: A Hospital-based Investigation of Breast Cancer Diagnostics Amid the Pandemic in Indonesia
Resilience in Healthcare: A Hospital-based Investigation of Breast Cancer Diagnostics Amid the Pandemic in Indonesia Open
Background: Widespread disruptions in healthcare services have occurred due to ongoing challenges during the pandemic. The tremendous impacts have struck countries with limited resources, greater distances of geographical access to healthc…
View article: Programmed death protein 1 (PD1) relationship with renal cell carcinoma subtype and staging
Programmed death protein 1 (PD1) relationship with renal cell carcinoma subtype and staging Open
Background: The programmed death protein 1 (PD-1) and its ligand have emerged as significant immunotherapies for renal cell carcinoma (RCC). However, the role of PD-1 expression as a molecular prognostic marker in RCC remains unclear. Mean…
View article: WNT/β-Catenin signaling pathway and clinicopathological factors in advanced stage non-small cell lung cancer: a multicenter study
WNT/β-Catenin signaling pathway and clinicopathological factors in advanced stage non-small cell lung cancer: a multicenter study Open
Background: This study aimed to assess the association of GSK-3β, β-catenin, and CD44 expressions, which are the molecules involved in the WNT/β-catenin signaling pathway, with clinicopathological profiles and their correlation with the re…
View article: Clinicopathologic Characteristics Influencing Overall Survival of Patients With Early- Versus Average-Onset Colorectal Cancer at a Tertiary Care Center in Indonesia
Clinicopathologic Characteristics Influencing Overall Survival of Patients With Early- Versus Average-Onset Colorectal Cancer at a Tertiary Care Center in Indonesia Open
PURPOSE There has been a global increase in early-onset colorectal cancer (EOCRC), yet there has been very limited exploration of its impact in Indonesia. This study aimed to determine the clinicopathologic characteristics and the overall …
View article: EGFR mutation based on lung laterality in adenocarcinoma type of non-small cell lung cancer
EGFR mutation based on lung laterality in adenocarcinoma type of non-small cell lung cancer Open
Targeted therapies have shown promise in improving survival rates for lung adenocarcinoma, a common and deadly malignancy. EGFR-targeting tyrosine kinase inhibitors (TKIs) are particularly effective among these therapies in cases with EGFR…
View article: Early Symptom Patterns by Tumor Laterality, Age at Onset, Stage, and Symptom-to-Treatment Initiation in Patients with Colorectal Cancer
Early Symptom Patterns by Tumor Laterality, Age at Onset, Stage, and Symptom-to-Treatment Initiation in Patients with Colorectal Cancer Open
The findings underlined the importance of maintaining a high clinical suspicion, particularly in patients with rectal masses and unexplained weight loss, as they might experience STI delay.
View article: G2/M Checkpoint Modulation: Insights from miRNA Profiles in FAM and Breast Cancer
G2/M Checkpoint Modulation: Insights from miRNA Profiles in FAM and Breast Cancer Open
Significant differences in the expression of multiple miRNAs between Luminal A and FAM samples were observed. Furthermore, several of these miRNAs were found to modulate the G2M Checkpoint in Luminal A cancer by suppressing tumor suppresso…
View article: High Probability of Lynch Syndrome Among Colorectal Cancer Patients Is Associated With Higher Occurrence of KRAS and PIK3CA Mutations
High Probability of Lynch Syndrome Among Colorectal Cancer Patients Is Associated With Higher Occurrence of KRAS and PIK3CA Mutations Open
The high probability of LS in Indonesian CRC patients is associated with KRAS and PIK3CA mutations.
View article: Green Seaweed Caulerpa racemosa as a Novel Non-Small Cell Lung Cancer Inhibitor in Overcoming Tyrosine Kinase Inhibitor Resistance: An Analysis Employing Network Pharmacology, Molecular Docking, and In Vitro Research
Green Seaweed Caulerpa racemosa as a Novel Non-Small Cell Lung Cancer Inhibitor in Overcoming Tyrosine Kinase Inhibitor Resistance: An Analysis Employing Network Pharmacology, Molecular Docking, and In Vitro Research Open
The marine environment provides a rich source of distinct creatures containing potentially revolutionary bioactive chemicals. One of these organisms is Caulerpa racemosa, a type of green algae known as green seaweed, seagrapes, or green ca…
View article: Unveiling the genetic landscape: high frequency of pik3ca mutation in luminal a and b breast cancer within the Indonesian population
Unveiling the genetic landscape: high frequency of pik3ca mutation in luminal a and b breast cancer within the Indonesian population Open
Background: Breast cancer (BC) is a global health concern with significant mortality rates, necessitating a deep understanding of its molecular landscape. Objective: This study focuses on the prevalence of phosphatidylinositol-4,5-bisphosp…
View article: Cytotoxic T lymphocyte associated antigen-4 (CTLA4) expression with renal cell carcinoma subtype and staging
Cytotoxic T lymphocyte associated antigen-4 (CTLA4) expression with renal cell carcinoma subtype and staging Open
In Indonesia, approximately 45% of renal cell carcinoma (RCC) patients are at an advanced stage that requires checkpoint inhibition combination immunotherapy. Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is associated with poor pro…
View article: Cigarette smoke-induced dysbiosis: comparative analysis of lung and intestinal microbiomes in COPD mice and patients
Cigarette smoke-induced dysbiosis: comparative analysis of lung and intestinal microbiomes in COPD mice and patients Open
Background The impact of cigarette smoke (CS) on lung diseases and the role of microbiome dysbiosis in chronic obstructive pulmonary disease (COPD) have been previously reported; however, the relationships remain unclear. Methods Our resea…
View article: 245P Antitumor-protumor ratio as an important prognostic biomarker in metastatic triple-negative breast cancer: A multicenter cohort study
245P Antitumor-protumor ratio as an important prognostic biomarker in metastatic triple-negative breast cancer: A multicenter cohort study Open
Triple-negative breast cancer (TNBC) had a higher mortality rate than other BCs. Antitumor–protumor interaction is pivotal in prognoses. This study analyzes antitumor–protumor immune activities and their ratios as prognostic biomarkers in …