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View article: Cell-specific <i>Eif2b5</i> mutant mice: novel insights into roles of macroglia in vanishing white matter
Cell-specific <i>Eif2b5</i> mutant mice: novel insights into roles of macroglia in vanishing white matter Open
Vanishing white matter (VWM) is a leukodystrophy caused by mutations in any of the genes encoding the subunits of the eukaryotic translation initiation factor 2B (eIF2B), a central factor in mRNA translation initiation and regulator of the…
View article: Lithium: effects in animal models of vanishing white matter are not promising
Lithium: effects in animal models of vanishing white matter are not promising Open
Vanishing white matter (VWM) is a devastating autosomal recessive leukodystrophy, resulting in neurological deterioration and premature death, and without curative treatment. Pathogenic hypomorphic variants in subunits of the eukaryotic in…
View article: Pridopidine subtly ameliorates motor skills in a mouse model for vanishing white matter
Pridopidine subtly ameliorates motor skills in a mouse model for vanishing white matter Open
The leukodystrophy vanishing white matter (VWM) is characterized by chronic and episodic acute neurological deterioration. Curative treatment is presently unavailable. Pathogenic variants in the genes encoding eukaryotic initiation factor …
View article: Guanabenz ameliorates disease in vanishing white matter mice in contrast to sephin1
Guanabenz ameliorates disease in vanishing white matter mice in contrast to sephin1 Open
Objective Vanishing white matter (VWM) is a leukodystrophy, characterized by stress‐sensitive neurological deterioration and premature death. It is currently without curative treatment. It is caused by bi‐allelic pathogenic variants in the…