Diego Alberti
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View article: Cobaltabis(dicarbollide) [ <i>o</i> -COSAN] <sup>−</sup> loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications
Cobaltabis(dicarbollide) [ <i>o</i> -COSAN] <sup>−</sup> loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications Open
Apoferritin-based nanohybrid, Apo:[ o -COSAN] − is designed as a high-capacity boron delivery system for BNCT acting as a multifunctional nanocarrier for targeted cancer therapy, combining high boron payloads with selective tumour cell upt…
View article: Combining BNCT with carbonic anhydrase inhibition for mesothelioma treatment: Synthesis, in vitro, in vivo studies of ureidosulfamido carboranes
Combining BNCT with carbonic anhydrase inhibition for mesothelioma treatment: Synthesis, in vitro, in vivo studies of ureidosulfamido carboranes Open
Mesothelioma is a malignant neoplasm of mesothelial cells caused by exposure to asbestos. The average survival time after diagnosis is usually nine/twelve months. A multi-therapeutic approach is therefore required to treat and prevent recu…
View article: A radical containing micellar probe for assessing esterase enzymatic activity with ultra-low field Overhauser-enhanced magnetic resonance imaging
A radical containing micellar probe for assessing esterase enzymatic activity with ultra-low field Overhauser-enhanced magnetic resonance imaging Open
In this study, we propose the use of an off/on probe, T2C 12 –T80, to monitor esterase activity in various cancer cell lines with Overhauser-MRI at an ultra-low field (206 μT), proving its sensitivity and suitability for in vivo translatio…
View article: Data from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
Data from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma Open
Specific targeting of tumors by combined delivery of drugs and of imaging agents represents an attractive strategy for treatment of cancer. The aim of the present study was to investigate whether neural cell adhesion molecule (NCAM)–target…
View article: Supplementary Figure 1 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
Supplementary Figure 1 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma Open
Supplementary Figure 1 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
View article: Supplementary Figure 2 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
Supplementary Figure 2 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma Open
Supplementary Figure 2 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
View article: Supplementary Figure 1 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
Supplementary Figure 1 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma Open
Supplementary Figure 1 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
View article: Data from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
Data from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma Open
Specific targeting of tumors by combined delivery of drugs and of imaging agents represents an attractive strategy for treatment of cancer. The aim of the present study was to investigate whether neural cell adhesion molecule (NCAM)–target…
View article: Supplementary Methods, Figure Legends 1-2 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
Supplementary Methods, Figure Legends 1-2 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma Open
Supplementary Methods, Figure Legends 1-2 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
View article: Supplementary Methods, Figure Legends 1-2 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
Supplementary Methods, Figure Legends 1-2 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma Open
Supplementary Methods, Figure Legends 1-2 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
View article: Supplementary Figure 2 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
Supplementary Figure 2 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma Open
Supplementary Figure 2 from Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule–Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma
View article: A novel pH sensitive theranostic PLGA nanoparticle for Boron Neutron Capture Therapy in Mesothelioma treatment
A novel pH sensitive theranostic PLGA nanoparticle for Boron Neutron Capture Therapy in Mesothelioma treatment Open
This study aims to develop poly lactic-co-glycolic acid (PLGA) nanoparticles with an innovative imaging-guided approach based on Boron Neutron Capture Therapy for the treatment of mesothelioma. The herein-reported results demonstrate that …
View article: Highly Sensitive “Off/On” EPR Probes to Monitor Enzymatic Activity
Highly Sensitive “Off/On” EPR Probes to Monitor Enzymatic Activity Open
The assessment of unregulated level of enzyme activity is a crucial parameter for early diagnoses in a wide range of pathologies. In this study, we propose the use of electron paramagnetic resonance (EPR) as an easy method to probe carboxy…
View article: LDL mediated delivery of Paclitaxel and MRI imaging probes for personalized medicine applications
LDL mediated delivery of Paclitaxel and MRI imaging probes for personalized medicine applications Open
Background : The combination of imaging and therapeutic agents in the same smart nanoparticle is a promising option to perform a minimally invasive imaging guided therapy. In this study, Low density lipoproteins (LDL), one of the most attr…
View article: Towards Enhanced MRI Performance of Tumor-Specific Dimeric Phenylboronic Contrast Agents
Towards Enhanced MRI Performance of Tumor-Specific Dimeric Phenylboronic Contrast Agents Open
It is known that phenylboronic acid (PBA) can target tumor tissues by binding to sialic acid, a substrate overexpressed by cancer cells. This capability has previously been explored in the design of targeting diagnostic probes such as Gd- …
View article: Solid-phase synthesis and evaluation of tumour-targeting phenylboronate-based MRI contrast agents
Solid-phase synthesis and evaluation of tumour-targeting phenylboronate-based MRI contrast agents Open
The advantage of a solid-phase synthetic strategy with DEAM-PS resin is applied for a clean and efficient preparation of water-soluble DOTA derivatives conjugated with phenylboronic functional groups.
View article: Ferritin: A Platform for MRI Contrast Agents Delivery
Ferritin: A Platform for MRI Contrast Agents Delivery Open
The search for high relaxivities and increased specificity continues to be central to the development of paramagnetic contrast agents for magnetic resonance imaging (MRI). Ferritin, due to its unique surface properties, architecture, and b…
View article: Efficient Route to Label Mesenchymal Stromal Cell-Derived Extracellular Vesicles
Efficient Route to Label Mesenchymal Stromal Cell-Derived Extracellular Vesicles Open
Recent research results report that extracellular vesicles (EVs) have a central role in both physiological and pathological processes involving intercellular communication. Herein, a simple EVs labeling procedure based on the metabolic lab…
View article: Cancer cell death induced by ferritins and the peculiar role of their labile iron pool
Cancer cell death induced by ferritins and the peculiar role of their labile iron pool Open
Cellular uptake of human H-ferritin loaded with 50 or 350 iron ions results in significant cytotoxicity on HeLa cells at submicromolar concentrations. Conversely, Horse Spleen Ferritin, that can be considered a model of L-cages, as it cont…
View article: Theranostic Nanoparticles Loaded with Imaging Probes and Rubrocurcumin for Combined Cancer Therapy by Folate Receptor Targeting
Theranostic Nanoparticles Loaded with Imaging Probes and Rubrocurcumin for Combined Cancer Therapy by Folate Receptor Targeting Open
The combination of different therapeutic modalities is a promising option to combat the recurrence of tumors. In this study, polylactic and polyglycolic acid nanoparticles were used for the simultaneous delivery of a boron–curcumin complex…