Diego Grassi
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Attenuation of Cellular Senescence and Improvement of Osteogenic Differentiation Capacity of Human Liver Stem Cells Using Specific Senomorphic and Senolytic Agents Open
Expansion of adult stem cells in culture increases the percent of senescent cells, reduces their differentiation capacity and limits their clinical use. Here, we investigated whether treatment with certain senotherapeutic drugs would reduc…
Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging Open
Aging drives progressive loss of the ability of tissues to recover from stress, partly through loss of somatic stem cell function and increased senescent burden. We demonstrate that bone marrow‐derived mesenchymal stem cells (BM‐MSCs) rapi…
Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend healthspan in mouse models of aging. Open
Source data file
Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend healthspan in mouse models of aging. Open
Source data file
Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease Open
Significance Parkinson’s disease (PD) is a neurodegenerative disease linked to the misfolding and aggregation of a protein called “α-synuclein.” α-Synuclein aggregates found in the brains of PD patients are called “Lewy bodies” and “Lewy n…
IGF-1 receptor regulates dynamic changes in neuronal polarity during cerebral cortical migration Open
During cortical development, neurons undergo polarization, oriented migration and layer-type differentiation. The biological and biochemical mechanisms underlying these processes are not completely understood. In neurons in culture we show…
Cytogenetic characterization of Hoplias malabaricus (Bloch, 1794) from the Ctalamochita River (Córdoba, Argentina): first evidence for southernmost populations of this species complex and comments on its biogeography Open
Hoplias malabaricus (Bloch, 1794), a predatory freshwater fish with a wide distribution throughout South America, represents a species complex with seven well characterized karyomorphs at the cytogenetic level. Although this species has be…