Diego Moriconi
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View article: Severe obesity associates with maladaptive glomerular haemodynamics clustered with insulin resistance and endothelial dysfunction
Severe obesity associates with maladaptive glomerular haemodynamics clustered with insulin resistance and endothelial dysfunction Open
Background Obesity is a leading risk factor for chronic kidney disease, with glomerular hyperfiltration as one of its earliest manifestations. However, absolute glomerular filtration rate (GFR) does not distinguish well between a pressure-…
View article: Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study
Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study Open
Background and Aims Increasing evidence suggests that COVID-19 survivors experience long-term cardiovascular complications possibly through development of vascular damage. The study aimed to investigate whether accelerated vascular ageing …
View article: Albumin‐To‐Creatinine Ratio Underestimates True 24‐Hour Albuminuria in Obesity: Clinical Relevance for Vascular Risk Stratification
Albumin‐To‐Creatinine Ratio Underestimates True 24‐Hour Albuminuria in Obesity: Clinical Relevance for Vascular Risk Stratification Open
Aims Albuminuria is a recognized marker of endothelial dysfunction and early cardiovascular risk. The albumin‐to‐creatinine ratio (ACR) is widely used to estimate urinary albumin excretion, but in individuals with high fat‐free mass (FFM),…
View article: Correction: Different formulations of semaglutide and oxidative stress in subjects with type 2 diabetes and MASLD: an open-label, real-life study
Correction: Different formulations of semaglutide and oxidative stress in subjects with type 2 diabetes and MASLD: an open-label, real-life study Open
View article: Cystatin C‐estimated GFR correlates with endothelial function improvements following bariatric surgery
Cystatin C‐estimated GFR correlates with endothelial function improvements following bariatric surgery Open
Background Obesity is a critical risk factor for chronic kidney disease and cardiovascular disease. The study aimed to explore the relationship between endothelial function, assessed by flow‐mediated dilation (FMD), and kidney function, es…
View article: Impact of kidney function on stiffness of small conduit arteries in hypertension and obesity
Impact of kidney function on stiffness of small conduit arteries in hypertension and obesity Open
Background: Arterial stiffness is a key cardiovascular risk factor influenced by conditions like hypertension, obesity and kidney function. Although large arteries have been extensively studied, small conduit arteries remain less investiga…
View article: Circadian heart rate fluctuations predict cardiovascular and all-cause mortality in type 2 and type 1 diabetes: a 21-year retrospective longitudinal study
Circadian heart rate fluctuations predict cardiovascular and all-cause mortality in type 2 and type 1 diabetes: a 21-year retrospective longitudinal study Open
Aims Circadian heart rate (HR) fluctuations are associated with cardiovascular health. We examined their relationship with microvascular disease and long-term survival in patients with diabetes. Methods and results In this secondary analys…
View article: Efficacy of Lisosan G (fermented wheat) on reactive hypoglycemia after bariatric surgery
Efficacy of Lisosan G (fermented wheat) on reactive hypoglycemia after bariatric surgery Open
LG effectively reduces PBH frequency and duration, probably by attenuating GLP-1 concentrations and leading to a decrease in the second phase of insulin secretion in response to glucose. These findings underscore the promise of LG as a nov…
View article: #723 The impact of kidney function on arterial stiffness in COVID-19 survivors: an analysis from CARTESIAN Study
#723 The impact of kidney function on arterial stiffness in COVID-19 survivors: an analysis from CARTESIAN Study Open
Background and Aims SARS-CoV-2 pandemic has been linked to an increased incidence of cardiovascular events, potentially due to accelerated vascular aging [1]. Conversely, impaired kidney function is known to contribute to the pathogenesis …
View article: Long-Term effects of physical activity on weight loss, metabolic parameters and blood pressure in subjects undergoing bariatric surgery: A 5-year follow-up study
Long-Term effects of physical activity on weight loss, metabolic parameters and blood pressure in subjects undergoing bariatric surgery: A 5-year follow-up study Open
regular PA demonstrated cardio-metabolic benefits post-bariatric surgery. Integrating PA into post-bariatric care could enhance long-term outcomes.
View article: Non-albumin proteinuria marks tubular involvement and is associated with arterial stiffness in subjects affected by severe obesity
Non-albumin proteinuria marks tubular involvement and is associated with arterial stiffness in subjects affected by severe obesity Open
iNAP subjects showed increased arterial stiffness comparable to that observed in ALB+ group, suggesting that they may represent a subgroup at higher cardiovascular risk, often unrecognized in clinical practice.
View article: #5834 ALBUMINURIA AND RENAL RESISTIVE INDEX ARE ASSOCIATED WITH MICROVASCULAR REMODELING IN PATIENTS WITH SEVERE OBESITY
#5834 ALBUMINURIA AND RENAL RESISTIVE INDEX ARE ASSOCIATED WITH MICROVASCULAR REMODELING IN PATIENTS WITH SEVERE OBESITY Open
Background and Aims Renal hemodynamics is impaired since the early stage of cardiometabolic disease. However, in severe obesity, its noninvasive assessment with ultrasound still fails to provide pathophysiologic and clinical meaningfulness…
View article: The renal resistive index is associated with microvascular remodeling in patients with severe obesity
The renal resistive index is associated with microvascular remodeling in patients with severe obesity Open
Background: Renal hemodynamics is impaired since the early stage of cardiometabolic disease. However, in obesity, its noninvasive ultrasound assessment still fails to provide pathophysiologic and clinical meaningfulness. We aimed to explor…
View article: Bariatric surgery to treat hypertension
Bariatric surgery to treat hypertension Open
View article: Glomerular hyperfiltration predicts kidney function decline and mortality in type 1 and type 2 diabetes: a 21-year longitudinal study
Glomerular hyperfiltration predicts kidney function decline and mortality in type 1 and type 2 diabetes: a 21-year longitudinal study Open
Objective. To evaluate the prognostic value of glomerular hyperfiltration on long-term kidney-related outcomes and mortality in subjects with diabetes. Methods. We retr…
View article: Glomerular hyperfiltration predicts kidney function decline and mortality in type 1 and type 2 diabetes: a 21-year longitudinal study
Glomerular hyperfiltration predicts kidney function decline and mortality in type 1 and type 2 diabetes: a 21-year longitudinal study Open
Objective. To evaluate the prognostic value of glomerular hyperfiltration on long-term kidney-related outcomes and mortality in subjects with diabetes. Methods. We retr…
View article: Glomerular Hyperfiltration Predicts Kidney Function Decline and Mortality in Type 1 and Type 2 Diabetes: A 21-Year Longitudinal Study
Glomerular Hyperfiltration Predicts Kidney Function Decline and Mortality in Type 1 and Type 2 Diabetes: A 21-Year Longitudinal Study Open
OBJECTIVE To evaluate the prognostic value of glomerular hyperfiltration on long-term kidney-related outcomes and mortality in patients with diabetes. RESEARCH DESIGN AND METHODS We retrospectively analyzed 21-year longitudinal data from 3…
View article: Diagnosis, Prevalence and Significance of Obesity in a Cohort of CKD Patients
Diagnosis, Prevalence and Significance of Obesity in a Cohort of CKD Patients Open
Background: data regarding the association between obesity and morbidity/mortality in patients with chronic kidney disease (CKD) are uncertain and sometimes contradictory. The aims of our study were to determine the associations among diff…
View article: A Multisystem Mitochondrial Disease Caused by a Novel <i>MT-TL1 mtDNA</i> Variant: A Case Report
A Multisystem Mitochondrial Disease Caused by a Novel <i>MT-TL1 mtDNA</i> Variant: A Case Report Open
Background: Mitochondrial tRNA (MTT) genes are hotspot for mitochondrial DNA mutation and are responsible of half mitochondrial disease. MTT mutations are associated with a broad spectrum of phenotype often with complex multisystem involve…
View article: Decreased Weight Loss Following Bariatric Surgery in Patients with Type 2 Diabetes
Decreased Weight Loss Following Bariatric Surgery in Patients with Type 2 Diabetes Open
View article: Idiopathic Retroperitoneal Fibrosis: What Is the Optimal Clinical Approach for Long-Term Preservation of Renal Function?
Idiopathic Retroperitoneal Fibrosis: What Is the Optimal Clinical Approach for Long-Term Preservation of Renal Function? Open
Background: The aim of this study was to investigate the long-term effects of ureteral stenting and the exact timing of stent removal in favor of surgery in patients with idiopathic retroperitoneal fibrosis (IRF). Summary: Medline research…
View article: The Beneficial Effects of Bariatric-Surgery-Induced Weight Loss on Renal Function
The Beneficial Effects of Bariatric-Surgery-Induced Weight Loss on Renal Function Open
Obesity represents an independent risk factor for the development of chronic kidney disease (CKD), leading to specific histopathological alterations, known as obesity-related glomerulopathy. Bariatric surgery is the most effective means of…
View article: Renal Sinus Fat Is Expanded in Patients with Obesity and/or Hypertension and Reduced by Bariatric Surgery Associated with Hypertension Remission
Renal Sinus Fat Is Expanded in Patients with Obesity and/or Hypertension and Reduced by Bariatric Surgery Associated with Hypertension Remission Open
Renal sinus fat is a fat depot at the renal hilum. Because of its location around the renal artery, vein, and lymphatic vessels, an expanded renal sinus fat mass may have hemodynamic and renal implications. We studied whether renal sinus f…
View article: Circulating neurofilament is linked with morbid obesity, renal function, and brain density
Circulating neurofilament is linked with morbid obesity, renal function, and brain density Open
View article: Reply to Landry et al. Findings from Diet Comparison Difficult to Interpret in the Absence of Adherence Assessment. Comment on “Tricò et al. Effects of Low-Carbohydrate versus Mediterranean Diets on Weight Loss, Glucose Metabolism, Insulin Kinetics and β-Cell Function in Morbidly Obese Individuals. Nutrients 2021, 13, 1345”
Reply to Landry et al. Findings from Diet Comparison Difficult to Interpret in the Absence of Adherence Assessment. Comment on “Tricò et al. Effects of Low-Carbohydrate versus Mediterranean Diets on Weight Loss, Glucose Metabolism, Insulin Kinetics and β-Cell Function in Morbidly Obese Individuals. Nutrients 2021, 13, 1345” Open
We thank Dr. Landry and colleagues [...]
View article: Predictors of type 2 diabetes relapse after Roux-en-Y Gastric Bypass: A ten-year follow-up study
Predictors of type 2 diabetes relapse after Roux-en-Y Gastric Bypass: A ten-year follow-up study Open
View article: Effects of Low-Carbohydrate versus Mediterranean Diets on Weight Loss, Glucose Metabolism, Insulin Kinetics and β-Cell Function in Morbidly Obese Individuals
Effects of Low-Carbohydrate versus Mediterranean Diets on Weight Loss, Glucose Metabolism, Insulin Kinetics and β-Cell Function in Morbidly Obese Individuals Open
Low-calorie Mediterranean-style or low-carbohydrate dietary regimens are widely used nutritional strategies against obesity and associated metabolic diseases, including type 2 diabetes. The aim of this study was to compare the effectivenes…
View article: Renal Involvement in IgG4-Related Disease: From Sunlight to Twilight
Renal Involvement in IgG4-Related Disease: From Sunlight to Twilight Open
IgG4-Related Disease (IgG4-RD) is a fibroinflammatory condition characterized by a typical histopathological pattern (dense lymphoplasmacytic infiltrate with prevalent IgG4+ plasma cells and storiform fibrosis), which may involve the kidne…
View article: Nephroprotection by SGLT2i in CKD Patients: May It Be Modulated by Low-Protein Plant-Based Diets?
Nephroprotection by SGLT2i in CKD Patients: May It Be Modulated by Low-Protein Plant-Based Diets? Open
Sodium-glucose-transporter 2 inhibitors (SGLT2i) are a new class of anti-diabetic drugs that in large trials such as CREDENCE have shown also a reduction of glomerular hyperfiltration and albuminuria in type 2 diabetic patients. Hence, the…
View article: Use of tocilizumab in amyloid a nephropathy associated with Sweet syndrome: a case report and literature review
Use of tocilizumab in amyloid a nephropathy associated with Sweet syndrome: a case report and literature review Open