Diego O. Nolasco
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View article: Balancing Dopamine: Managing Parkinson’s Disease and Psychiatric Symptoms through Agonist-Antagonist Pharmacotherapy
Balancing Dopamine: Managing Parkinson’s Disease and Psychiatric Symptoms through Agonist-Antagonist Pharmacotherapy Open
Introduction Parkinson’s disease (PD) is characterized by basal ganglia dopamine depletion, leading to motor symptoms. Psychiatric symptoms, like psychosis, are associated with dopamine overactivity in the mesolimbic and mesocortical syste…
View article: Systemic Inflammation from Periodontal Disease and its Neuropsychiatric Implications
Systemic Inflammation from Periodontal Disease and its Neuropsychiatric Implications Open
Introduction Chronic oral health issues, particularly periodontal disease, are significant contributors to systemic inflammation. Emerging evidence indicates that this inflammation can influence neurophysiological processes and contribute …
View article: Comparative transcriptomic analysis indicates genes associated with local and systemic resistance to Colletotrichum graminicola in maize
Comparative transcriptomic analysis indicates genes associated with local and systemic resistance to Colletotrichum graminicola in maize Open
The hemibiotrophic fungus Colletotrichum graminicola may cause severe damage to maize, affecting normal development of the plant and decreasing grain yield. In this context, understanding plant defense pathways at the inoculation site and …
View article: Revealing a Novel Otubain-Like Enzyme from Leishmania infantum with Deubiquitinating Activity toward K48-Linked Substrate
Revealing a Novel Otubain-Like Enzyme from Leishmania infantum with Deubiquitinating Activity toward K48-Linked Substrate Open
Deubiquitinating enzymes (DUBs) play an important role in regulating a variety of eukaryotic processes. In this context, exploring the role of deubiquitination in Leishmania infantum could be a promising alternative to search new th…
View article: Mycobacterium tuberculosis Prolyl Oligopeptidase Induces In vitro Secretion of Proinflammatory Cytokines by Peritoneal Macrophages
Mycobacterium tuberculosis Prolyl Oligopeptidase Induces In vitro Secretion of Proinflammatory Cytokines by Peritoneal Macrophages Open
Tuberculosis (TB) is a disease that leads to death over 1 million people per year worldwide and the biological mediators of this pathology are poorly established, preventing the implementation of effective therapies to improve outcomes in …
View article: Correction: Corrigendum: A polyalanine peptide derived from polar fish with anti-infectious activities
Correction: Corrigendum: A polyalanine peptide derived from polar fish with anti-infectious activities Open
View article: A polyalanine peptide derived from polar fish with anti-infectious activities
A polyalanine peptide derived from polar fish with anti-infectious activities Open
View article: Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum
Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum Open
View article: 315. Optimization of the Capsid of Recombinant Adeno-Associated Virus 6 (AAV6) Vectors for Liver-, and Muscle-Directed Gene Therapy
315. Optimization of the Capsid of Recombinant Adeno-Associated Virus 6 (AAV6) Vectors for Liver-, and Muscle-Directed Gene Therapy Open
Recombinant adeno-associated virus (AAV) vectors are currently in use in a number of Phase I/II clinical trials. However, large vector doses are needed to achieve therapeutic effects. The ubiquitinproteasome pathway plays a critical role i…
View article: Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features
Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features Open