Diego Robledo
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View article: Optimization of reference population for imputation of low-density SNPs panel for genomic prediction in Atlantic salmon.
Optimization of reference population for imputation of low-density SNPs panel for genomic prediction in Atlantic salmon. Open
In recent years many advances have been made towards developing cost-efficient low-density genomic tools for a wider implementation of genomic selection in aquaculture breeding programmes. Genotype imputation from very low-density (LD) SNP…
View article: Comparative Analysis of CRISPR/Cas9 Delivery Methods in Marine Teleost Cell Lines
Comparative Analysis of CRISPR/Cas9 Delivery Methods in Marine Teleost Cell Lines Open
Gene editing technologies such as CRISPR/Cas9 have revolutionized functional genomics, yet their application in marine fish cell lines remains limited by inefficient delivery. This study compares three delivery strategies—electroporation, …
View article: Amoebic Gill Disease ( <scp>AGD</scp> ) in Atlantic Salmon Investigated Through a Holo‐Omic Lens
Amoebic Gill Disease ( <span>AGD</span> ) in Atlantic Salmon Investigated Through a Holo‐Omic Lens Open
Interactions between host genetics and the resident microbiota are complex. Understanding these interactions offers interesting alternatives for addressing gill health and disease resistance in salmonids. Amoebic gill disease (AGD), caused…
View article: Characterisation of post-translational and transcriptional reprogramming of the immune response to ISAV and IPNV infections in salmon head kidney cells
Characterisation of post-translational and transcriptional reprogramming of the immune response to ISAV and IPNV infections in salmon head kidney cells Open
Viral diseases remain a major barrier to the sustainable production of farmed fish, primarily attributable to the absence of effective prevention and treatment options. Understanding host-pathogen interactions can guide the development of …
View article: Full-length hybrid transcriptome of the olfactory rosette in Senegalese sole ( <i>Solea senegalensis</i> ): an essential genomic resource for improving reproduction on farms
Full-length hybrid transcriptome of the olfactory rosette in Senegalese sole ( <i>Solea senegalensis</i> ): an essential genomic resource for improving reproduction on farms Open
Senegalese sole is a promising European aquaculture species whose main challenge is that captive-born males (F1) are unable to reproduce in farms, hindering breeding programs. Chemical communication through the olfactory system is hypothes…
View article: Structural variant landscape provides insights into genome organisation and domestication in European seabass
Structural variant landscape provides insights into genome organisation and domestication in European seabass Open
View article: Comparative Analysis of CRISPR/Cas9 Delivery Methods in Marine Teleost Cell Lines
Comparative Analysis of CRISPR/Cas9 Delivery Methods in Marine Teleost Cell Lines Open
Gene editing technologies such as CRISPR/Cas9 have revolutionized functional genomics, yet their application in marine fish cell lines remains limited by inefficient delivery. This study compares three delivery strategies—electroporation, …
View article: Local inflammation at the salmon louse (Lepeophtheirus salmonis) attachment site contributes to copepodid rejection in coho salmon (Oncorhynchus kisutch)
Local inflammation at the salmon louse (Lepeophtheirus salmonis) attachment site contributes to copepodid rejection in coho salmon (Oncorhynchus kisutch) Open
The study investigates the susceptibility of Atlantic salmon ( Salmo salar ) and Pacific salmon species (pink salmon, Oncorhynchus gorbuscha ; coho salmon, Oncorhynchus kisutch ; and chum salmon, Oncorhynchus keta ) to the parasitic salmon…
View article: Tryptophan-induced transcriptomic changes in the European Seabass are highly dependent on neuroendocrine-immune conditions
Tryptophan-induced transcriptomic changes in the European Seabass are highly dependent on neuroendocrine-immune conditions Open
View article: WITHDRAWN: Triple gene disruption confers genetic resistance to infectious salmon anaemia virus in Atlantic salmon ( <i>Salmo salar</i> )
WITHDRAWN: Triple gene disruption confers genetic resistance to infectious salmon anaemia virus in Atlantic salmon ( <i>Salmo salar</i> ) Open
Withdrawal Statement The authors have withdrawn their manuscript because it was submitted and made public without full consent of all authors. Therefore, the authors do not wish this work to be cited as reference for the project. If you ha…
View article: WITHDRAWN: Codon-Optimized Base Editors Enable Efficient Base Substitution in Non-model Animals
WITHDRAWN: Codon-Optimized Base Editors Enable Efficient Base Substitution in Non-model Animals Open
Statement for withdrawal The authors have withdrawn their manuscript because it was submitted and made public without full consent of all authors. Therefore, the authors do not wish this work to be cited as reference for the project. If yo…
View article: Transcriptomic characterization of transitioning cell types in the skin of Atlantic salmon
Transcriptomic characterization of transitioning cell types in the skin of Atlantic salmon Open
View article: High performance imputation of structural and single nucleotide variants using low-coverage whole genome sequencing
High performance imputation of structural and single nucleotide variants using low-coverage whole genome sequencing Open
View article: Comparative transcriptomic profiling of gonads in Solea senegalensis: Exploring sex, maturity, and origin variations
Comparative transcriptomic profiling of gonads in Solea senegalensis: Exploring sex, maturity, and origin variations Open
View article: FULL-LENGTH HYBRID TRANSCRIPTOME OF THE OLFACTORY ROSETTE IN SENEGALESE SOLE (<i>Solea senegalensis</i>): AN ESSENTIAL GENOMIC RESOURCE TO IMPROVE REPRODUCTION AT FARMS
FULL-LENGTH HYBRID TRANSCRIPTOME OF THE OLFACTORY ROSETTE IN SENEGALESE SOLE (<i>Solea senegalensis</i>): AN ESSENTIAL GENOMIC RESOURCE TO IMPROVE REPRODUCTION AT FARMS Open
Senegalese sole is a promising European aquaculture species whose main challenge is that captive-born males (F1) are unable to reproduce in farms, hindering breeding programs. Chemical communication through the olfactory system is hypothes…
View article: Integrated functional genomic analysis identifies regulatory variants underlying a major QTL for disease resistance in European sea bass
Integrated functional genomic analysis identifies regulatory variants underlying a major QTL for disease resistance in European sea bass Open
View article: Advances in genetic and genomic resources in Pacific whiteleg shrimp Penaeus vannamei: Towards modern and sustainable shrimp aquaculture
Advances in genetic and genomic resources in Pacific whiteleg shrimp Penaeus vannamei: Towards modern and sustainable shrimp aquaculture Open
Genetic improvement of Pacific whiteleg shrimp Penaeus vannamei, the most economically important crustacean worldwide, is key to ensuring shrimp aquaculture's sustainability. Maximizing the potential of this industry requires implementing …
View article: A single-nucleus RNA sequencing atlas of the postnatal retina of the shark Scyliorhinus canicula
A single-nucleus RNA sequencing atlas of the postnatal retina of the shark Scyliorhinus canicula Open
The retina, whose basic cellular structure is highly conserved across vertebrates, constitutes an accessible system for studying the central nervous system. In recent years, single-cell RNA sequencing studies have uncovered cellular divers…
View article: Exploring the effects of dietary methionine supplementation on European seabass mucosal immune responses against Tenacibaculum maritimum
Exploring the effects of dietary methionine supplementation on European seabass mucosal immune responses against Tenacibaculum maritimum Open
Introduction Dietary methionine supplementation has been shown to enhance immunity and disease resistance in fish. However, excessive intake may lead to adverse effects. The present study aimed to evaluate the immune status of European sea…
View article: Insights into Solea senegalensis Reproduction Through Gonadal Tissue Methylation Analysis and Transcriptomic Integration
Insights into Solea senegalensis Reproduction Through Gonadal Tissue Methylation Analysis and Transcriptomic Integration Open
Fish exhibit diverse mechanisms of sex differentiation and determination, shaped by both external and internal influences, often regulated by distinct DNA methylation patterns responding to environmental changes. In S. senegalensis aquacul…
View article: Towards New Horizons in Shrimp Cell Culture: A Streamlined Protocol for Culturing Healthy, Enduring Haemocytes and Lymphoid Organ Cells from Pacific Whiteleg Shrimp (Litopenaeus Vannamei)
Towards New Horizons in Shrimp Cell Culture: A Streamlined Protocol for Culturing Healthy, Enduring Haemocytes and Lymphoid Organ Cells from Pacific Whiteleg Shrimp (Litopenaeus Vannamei) Open
View article: Insights into Solea senegalensis Reproduction through Gonadal Tissue Methylation Analysis and Transcriptomic Integration
Insights into Solea senegalensis Reproduction through Gonadal Tissue Methylation Analysis and Transcriptomic Integration Open
Fish exhibit diverse mechanisms of sex differentiation and determination, influenced by both external and internal factors, often regulated by distinct DNA methylation patterns responding to environmental changes. In S. senegalensis aquacu…
View article: Tryptophan-induced transcriptomic changes in the European seabass (Dicentrarchus labrax) are highly dependent on neuroendocrine-immune conditions
Tryptophan-induced transcriptomic changes in the European seabass (Dicentrarchus labrax) are highly dependent on neuroendocrine-immune conditions Open
In European seabass (Dicentrarchus labrax), dietary tryptophan (TRP) surplus has a notable modulatory effect on the hypothalamic–pituitary–interrenal axis under chronic stress and acute inflammation, affecting cortisol levels and neuroendo…
View article: Differential Ubiquitination of Host Proteins in Response to IPNV and ISAV viruses in Atlantic salmon
Differential Ubiquitination of Host Proteins in Response to IPNV and ISAV viruses in Atlantic salmon Open
Viral diseases remain a major barrier to the sustainable production of farmed fish, primarily attributable to the absence of effective prevention and treatment options. Understanding host-pathogen interactions can guide the development of …
View article: Methylation profile of the testes of the flatfish Solea senegalensis
Methylation profile of the testes of the flatfish Solea senegalensis Open
In aquaculture production, fish phenotypes are influenced by a combination of external and internal factors, while the underlying mechanisms often involve distinct DNA methylation patterns. These play a fundamental role in regulating gene …
View article: Local inflammation at the salmon louse (Lepeophtheirus salmonis) attachment site drives copepodid rejection in Coho Salmon (Oncorhynchus kisutch)
Local inflammation at the salmon louse (Lepeophtheirus salmonis) attachment site drives copepodid rejection in Coho Salmon (Oncorhynchus kisutch) Open
Salmon louse (Lepeophtheirus salmonis) poses significant risks to both wild and farmed salmon populations. Atlantic Salmon (Salmo salar) are highly susceptible to the parasite, while Pacific salmon species such as Pink (Oncorhynchus gorbus…
View article: Keratinocytes drive the epithelial hyperplasia key to sea lice resistance in coho salmon
Keratinocytes drive the epithelial hyperplasia key to sea lice resistance in coho salmon Open
View article: Transcriptome Analysis Reveals the Immunosuppression in Tiger Pufferfish (Takifugu rubripes) under Cryptocaryon irritans Infection
Transcriptome Analysis Reveals the Immunosuppression in Tiger Pufferfish (Takifugu rubripes) under Cryptocaryon irritans Infection Open
The tiger pufferfish (Takifugu rubripes), also known as fugu, has recently suffered from severe C. irritans infections under aquaculture environment, yet the underlying immune mechanisms against the parasite remain poorly understood. In th…
View article: Integrated functional genomic analysis identifies the regulatory variants underlying a major QTL for disease resistance in European sea bass
Integrated functional genomic analysis identifies the regulatory variants underlying a major QTL for disease resistance in European sea bass Open
Background Viral nervous necrosis (VNN) is a viral disease threatening the sustainability of global aquaculture, and affecting over 50 of farmed and ecologically important species. A major QTL for resistance to VNN has been previously desc…
View article: Effect of CRISPR/Cas9 Targets Associated with Iron Metabolism and Its Variation on Transcriptional Regulation of SHK-1 Cell Line as a Model for Iron Metabolism
Effect of CRISPR/Cas9 Targets Associated with Iron Metabolism and Its Variation on Transcriptional Regulation of SHK-1 Cell Line as a Model for Iron Metabolism Open
In this study, we investigated the function of a gene associated with iron metabolism using CRISPR-Cas9 and RNA sequencing in SHK-1 salmon cells. Our objective was to understand how different guide RNA (gRNA) sequences against the transfer…