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View article: Hepatocyte-specific angiotensinogen deficiency inhibits Western diet-induced liver steatosis with suppression of cell division in mice
Hepatocyte-specific angiotensinogen deficiency inhibits Western diet-induced liver steatosis with suppression of cell division in mice Open
Liver steatosis is a common cause of chronic liver disease. To investigate the molecular basis of hepatic steatosis, low-density lipoprotein receptor-deficient (LDLR -/-) mice were fed a Western diet (WD, 42% of calories from fat) for 5, 1…
View article: Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation
Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation Open
Systemic blood coagulation accompanies inflammation during severe infections like sepsis and COVID. We previously established a link between coagulopathy and pyroptosis, a vital defense mechanism against infection. During pyroptosis, the f…
View article: Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasomeinduced blood coagulation and inflammation
Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasomeinduced blood coagulation and inflammation Open
Systemic blood coagulation accompanies inflammation during severe infection like sepsis and COVID. We’ve previously established a link between pyroptosis, a vital defense mechanism against infection, and coagulopathy. During pyroptosis, th…
View article: Counteracting Angiotensinogen Small-Interfering RNA-Mediated Antihypertensive Effects With REVERSIR
Counteracting Angiotensinogen Small-Interfering RNA-Mediated Antihypertensive Effects With REVERSIR Open
BACKGROUND: Small-interfering RNA (siRNA) targeting hepatic AGT (angiotensinogen) mRNA depletes AGT, lowering blood pressure for up to 6 months. However, certain situations may require a rapid angiotensin increase. The REVERSIR (RVR) - rev…
View article: Targeting Angiotensinogen With <i>N</i> -Acetylgalactosamine–Conjugated Small Interfering RNA to Reduce Blood Pressure
Targeting Angiotensinogen With <i>N</i> -Acetylgalactosamine–Conjugated Small Interfering RNA to Reduce Blood Pressure Open
Blood pressure management involves antihypertensive therapies blocking the renin-angiotensin system (RAS). Yet, it might be inadequate due to poor patient adherence or the so-called RAS escape phenomenon, elicited by the compensatory renin…
View article: Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation
Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation Open
Systemic blood coagulation accompanies inflammation during severe infections like sepsis and COVID. We previously established a link between coagulopathy and pyroptosis, a vital defense mechanism against infection. During pyroptosis, the f…
View article: Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasomeinduced blood coagulation and inflammation
Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasomeinduced blood coagulation and inflammation Open
Systemic blood coagulation accompanies inflammation during severe infection like sepsis and COVID. We’ve previously established a link between pyroptosis, a vital defense mechanism against infection, and coagulopathy. During pyroptosis, th…
View article: Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice
Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice Open
Background and objective Whole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis development. A deficit in the literature has been a lack of attention to the effect…
View article: Antisense oligonucleotides targeting hepatic angiotensinogen reduce atherosclerosis and liver steatosis in hypercholesterolemic mice
Antisense oligonucleotides targeting hepatic angiotensinogen reduce atherosclerosis and liver steatosis in hypercholesterolemic mice Open
Hepatocyte-derived angiotensinogen (AGT) is the precursor of angiotensin II (AngII). We determined the effects of hepatocyte-specific (N-acetylgalactosamine-conjugated) antisense oligonucleotides targeting AGT (GalNAc AGT ASO) on AngII-med…
View article: Angiotensinogen Suppression: A New Tool to Treat Cardiovascular and Renal Disease
Angiotensinogen Suppression: A New Tool to Treat Cardiovascular and Renal Disease Open
Multiple types of renin-angiotensin system (RAS) blockers exist, allowing interference with the system at the level of renin, angiotensin-converting enzyme, or the angiotensin II receptor. Yet, in particular, for the treatment of hypertens…
View article: Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile–Induced Thoracic Aortopathy in Mice—Brief Report
Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile–Induced Thoracic Aortopathy in Mice—Brief Report Open
Background: Cross-linking of lysine residues in elastic and collagen fibers is a vital process in aortic development. Inhibition of lysyl oxidase by BAPN (β-aminopropionitrile) leads to thoracic aortopathies in mice. Although the renin-ang…
View article: Conventional Vasopressor and Vasopressor‐Sparing Strategies to Counteract the Blood Pressure–Lowering Effect of Small Interfering RNA Targeting Angiotensinogen
Conventional Vasopressor and Vasopressor‐Sparing Strategies to Counteract the Blood Pressure–Lowering Effect of Small Interfering RNA Targeting Angiotensinogen Open
Background A single dose of small interfering RNA (siRNA) targeting liver angiotensinogen eliminates hepatic angiotensinogen and lowers blood pressure. Angiotensinogen elimination raises concerns for clinical application because an angiote…
View article: Fludrocortisone Induces Aortic Pathologies in Mice
Fludrocortisone Induces Aortic Pathologies in Mice Open
Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was …
View article: ANTISENSE OLIGONUCLEOTIDES TARGETING HEPATIC ANGIOTENSINOGEN DOSE-DEPENDENTLY REDUCE ATHEROSCLEROSIS AND LIVER STEATOSIS IN HYPERCHOLESTEROLEMIC MICE
ANTISENSE OLIGONUCLEOTIDES TARGETING HEPATIC ANGIOTENSINOGEN DOSE-DEPENDENTLY REDUCE ATHEROSCLEROSIS AND LIVER STEATOSIS IN HYPERCHOLESTEROLEMIC MICE Open
Objective: Liver-derived angiotensinogen (AGT) is the substrate from which renin and ACE generate angiotensin (Ang) II. Ang II not only increases blood pressure, but also is a major determinant of atherosclerosis in hypercholesteremic mice…
View article: Fludrocortisone Induces Aortic Pathologies in Mice
Fludrocortisone Induces Aortic Pathologies in Mice Open
Background and Objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was …
View article: Research Progress of Olfactory Nerve Regeneration Mechanism and Olfactory Training
Research Progress of Olfactory Nerve Regeneration Mechanism and Olfactory Training Open
Bian Hu,1,2 Jingyu Zhang,3 Mengdan Gong,1 Yongqin Deng,1 Yujie Cao,1 Yizhen Xiang,1 Dong Ye1 1Department of Otorhinolaryngology-Head and Neck Surgery, Lihuili Hospital of Ningbo University, Ningbo, 315040, Zhejiang, People’s Republic of Ch…
View article: (Pro)renin Receptor Inhibition Reduces Plasma Cholesterol and Triglycerides but Does Not Attenuate Atherosclerosis in Atherosclerotic Mice
(Pro)renin Receptor Inhibition Reduces Plasma Cholesterol and Triglycerides but Does Not Attenuate Atherosclerosis in Atherosclerotic Mice Open
Objective: Elevated plasma cholesterol concentrations contributes to ischemic cardiovascular diseases. Recently, we showed that inhibiting hepatic (pro)renin receptor [(P)RR] attenuated diet-induced hypercholesterolemia and hypertriglyceri…
View article: Renal Angiotensinogen Is Predominantly Liver Derived in Nonhuman Primates
Renal Angiotensinogen Is Predominantly Liver Derived in Nonhuman Primates Open
[Figure: see text].
View article: Deletion of AT1a (Angiotensin II Type 1a) Receptor or Inhibition of Angiotensinogen Synthesis Attenuates Thoracic Aortopathies in Fibrillin1 <sup>C1041G/+</sup> Mice
Deletion of AT1a (Angiotensin II Type 1a) Receptor or Inhibition of Angiotensinogen Synthesis Attenuates Thoracic Aortopathies in Fibrillin1 <sup>C1041G/+</sup> Mice Open
Objective: A cardinal feature of Marfan syndrome is thoracic aortic aneurysm. The contribution of the renin-angiotensin system via AT1aR (Ang II [angiotensin II] receptor type 1a) to thoracic aortic aneurysm progression remains controversi…
View article: Renal Angiotensinogen is Predominantly Liver-Derived in Nonhuman Primates
Renal Angiotensinogen is Predominantly Liver-Derived in Nonhuman Primates Open
AGT (Angiotensinogen) is the unique substrate of the renin-angiotensin system. Liver is the primary source of circulating AGT. The present study determined whether hepatocyte-derived AGT regulates renal AGT accumulation by injecting ASO (a…
View article: GSDMD Deficiency Protects Against Aortic Rupture
GSDMD Deficiency Protects Against Aortic Rupture Open
Objective Aortic ruptures are fatal consequences of aortic aneurysms with macrophage accumulation being a hallmark at the site of ruptures. Pyroptosis is critical in macrophage-mediated inflammation. This study determined effects of pyropt…
View article: Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression
Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression Open
A CE2 (angiotensin-converting enzyme 2) degrades Ang (an- giotensin) I and II and is a cellular receptor for severe acute respiratory syndrome coronavirus 2, the virus that causes coronavirus disease 2019 (COVID-19).Viral entry into host c…
View article: Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression: Insights into COVID-19
Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression: Insights into COVID-19 Open
Angiotensin-converting enzyme 2 (ACE2), a component of the renin-angiotensin system, is a receptor for SARS-CoV-2, the virus that causes COVID-19. To determine whether the renin-angiotensin inhibition regulates ACE2 expression, either enal…
View article: Hydrogen Therapy: Acid‐Responsive H<sub>2</sub>‐Releasing 2D MgB<sub>2</sub> Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy (Adv. Healthcare Mater. 13/2019)
Hydrogen Therapy: Acid‐Responsive H<sub>2</sub>‐Releasing 2D MgB<sub>2</sub> Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy (Adv. Healthcare Mater. 13/2019) Open
In article number 1900157 by Qianjun He and co-workers, a two-dimensional magnesium boride nanosheet (MBN) is developed as a new type of acid-responsive hydrogen-releasing prodrug to realize combined hydrogenochemotherapy of gastric cancer…
View article: (Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis
(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis Open
Rationale: An elevated level of plasma LDL (low-density lipoprotein) is an established risk factor for cardiovascular disease. Recently, we reported that the (pro)renin receptor ([P]RR) regulates LDL metabolism in vitro via the LDLR (LDL r…