Dieter Krause
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View article: Development and Validation of a Novel Stenosis Model for Percutaneous Transluminal Angioplasty Training of the Internal Carotid Artery
Development and Validation of a Novel Stenosis Model for Percutaneous Transluminal Angioplasty Training of the Internal Carotid Artery Open
Introduction/Background The rising demand for endovascular stroke therapy highlights the need for standardized training environments. Studies have shown the positive impact of simulator-based training for neurointerventional procedures. Gi…
View article: Approach for investigation of CFRP tribological stressed interfaces through levels of abstraction
Approach for investigation of CFRP tribological stressed interfaces through levels of abstraction Open
Carbon Fiber Reinforced Plastics (CFRP) offer high lightweight potential, particularly for dynamic machine components due to their strength-to-weight ratio and low thermal expansion. However, integrating CFRP into stressed interfaces, such…
View article: Enhancing end-of-life sustainability through modularity and interface design in product development
Enhancing end-of-life sustainability through modularity and interface design in product development Open
This study highlights the importance of interface design in sustainable product development within a circular economy. By focusing on the end-of-life (EOL) phase, the research emphasizes modular product architectures’ role in improving com…
View article: A new design method to account for interlaminar stresses in laminated composites using machine learning
A new design method to account for interlaminar stresses in laminated composites using machine learning Open
Lightweight design is critical for improving the efficiency and sustainability of engineering applications. Laminated composites, with their high strength-to-weight ratio and tailored material properties, play a key role but introduce inte…
View article: Supporting medical phantom design through a comprehensive design catalogue for phantom materials
Supporting medical phantom design through a comprehensive design catalogue for phantom materials Open
Medical phantoms are models used for imaging and therapy, enabling research, quality assurance, and training without human test subjects. Their development relies on selecting tissue-mimicking materials, however the lack of a holistic over…
View article: Towards improving the information management of aircraft cabin retrofits by processing quantity-on-hand documents
Towards improving the information management of aircraft cabin retrofits by processing quantity-on-hand documents Open
Retrofitting aircraft cabins is characterized by a large number of documents created and required, most of which are currently processed manually. Engineers need to identify which documents include the information that is required for a sp…
View article: Challenges in addressing sustainability within product development
Challenges in addressing sustainability within product development Open
Due to climate change, sustainability has become a crucial topic in product development, while addressing it is associated with many challenges. Based on a literature review, those challenges are collected and clustered into nine categorie…
View article: Flexibility evaluation of modules with a focus on interfaces
Flexibility evaluation of modules with a focus on interfaces Open
In the context of volatile markets, characterised by a need for continuous product development involving module-wise product modifications, the importance of flexibility as an attribute of products and their production system has been incr…
View article: Leveraging generative AI tools for design method support: insights, challenges, and best practices
Leveraging generative AI tools for design method support: insights, challenges, and best practices Open
Publicly available generative AI tools, such as ChatGPT, Midjourney, and DALL-E 3, have the potential to transform product development by accelerating tasks and improving design ideation. Through case studies of scenario management and per…
View article: Towards an indicator for assessing the potential for geometric standardization in the development of variant lightweight products
Towards an indicator for assessing the potential for geometric standardization in the development of variant lightweight products Open
Product development is a dynamic, multidisciplinary field shaped by evolving customer demands and the need for individualized products, increasing product variety. Key factors include economic performance, customer satisfaction, and sustai…
View article: Scenario-based planning of design method validation studies and the associated effort
Scenario-based planning of design method validation studies and the associated effort Open
Design method validation is fundamental to ensure that design methods achieve their objectives in the intended situations and are accepted in practice. Although various method validation approaches have been developed, there is still a lac…
View article: Developing and testing 3D printed models of arteriovenous malformations for embolization training in interventional neuroradiology
Developing and testing 3D printed models of arteriovenous malformations for embolization training in interventional neuroradiology Open
The advancement of technology and the development of smaller treatment instruments has enabled the utilization of neurointerventional procedures to treat conditions affecting small vessels (>2mm). One example is an arteriovenous malform…
View article: Experimental Investigation of the Vibration Behaviour of Variant GFRP Sandwich Panels in Thermal Environment
Experimental Investigation of the Vibration Behaviour of Variant GFRP Sandwich Panels in Thermal Environment Open
In this study, the impact of temperature on the eigenfrequencies and amplifications of four variant GFRP sandwich panels with aramid honeycomb cores is investigated. Tests are carried out at temperatures from −40°C to 120°C, which are typi…
View article: Middle Meningeal Artery Model for Training Endovascular Treatment of Chronic Subdural Hematomas in Interventional Neuroradiology
Middle Meningeal Artery Model for Training Endovascular Treatment of Chronic Subdural Hematomas in Interventional Neuroradiology Open
Technical progress and the development of smaller treatment instruments allow neurointerventional procedures to be used to treat diseases involving small vessels (< 2 mm). One example is the subdural hematoma (SDH), which can be treated…
View article: Vibration reduction of lightweight structures through adjustable damping and stiffness properties at their interfaces
Vibration reduction of lightweight structures through adjustable damping and stiffness properties at their interfaces Open
This paper presents the vibration reduction of lightweight components by adjusting the mechanical properties of their boundary conditions in vibration test rigs. The variable boundary conditions are achieved by adjustable impedance element…
View article: Model of the Venous System for Training Endovascular Treatment in Interventional Neuroradiology
Model of the Venous System for Training Endovascular Treatment in Interventional Neuroradiology Open
Background: Endovascular treatment of venous disease is introducing new therapeutic options in neuroradiology. These procedures are technically challenging and require extensive physician training. Currently, training is mainly conducted o…
View article: Development of a model-based modular building kit for sensor-integrating machine elements—Theory and application
Development of a model-based modular building kit for sensor-integrating machine elements—Theory and application Open
In the Priority Program 2305 of the German Research Foundation, so-called Sensor-integrating Machine Elements (SiME) are to be developed. These are essentially highly standardized components with integrated microelectronics. The present ar…
View article: HANNES: A Modular Neurointerventional Training Model
HANNES: A Modular Neurointerventional Training Model Open
This work introduces version 2.0 of the Hamburg ANatomical NEurointerventional Simulator (HANNES): a novel modular neurointerventional simulator designed to provide a realistic platform for simulating various neurovascular pathologies and …
View article: Three-Dimensional-Bioprinted Non-Small Cell Lung Cancer Models in a Mouse Phantom for Radiotherapy Research
Three-Dimensional-Bioprinted Non-Small Cell Lung Cancer Models in a Mouse Phantom for Radiotherapy Research Open
Lung cancer continues to have one of the highest morbidity and mortality rates of any cancer. Although radiochemotherapy, in combination with immunotherapy, has significantly improved overall survival, new treatment options are urgently ne…
View article: The influence of R/t-ratio on the imperfection sensitivity of the buckling load of thin-walled CFRP cylindrical shells
The influence of R/t-ratio on the imperfection sensitivity of the buckling load of thin-walled CFRP cylindrical shells Open
Thin-walled cylindrical shells under axial compression load are prone to buckling. The influencing factors leading to a reduction of the buckling load are a major design challenge. The sensitivity to imperfection increases with rising slen…
View article: Printing study and design guideline for small hollow structures in medical technology
Printing study and design guideline for small hollow structures in medical technology Open
In recent years, interest in additive manufacturing has increased. To overcome challenges such as the correct use of the technology, guidelines are needed to help the user in the fabrication process. However, such guidance is not currently…
View article: Applying a product modularization approach on the case of a battery pack
Applying a product modularization approach on the case of a battery pack Open
When designing battery packs, opposing target-conflicts and design goals arise due to the different disciplines involved in the development process. Looking at the available technologies for battery pack design, different solutions can be …
View article: Enhancing design representations of information and knowledge of complex and long-living assets by applying system modelling techniques
Enhancing design representations of information and knowledge of complex and long-living assets by applying system modelling techniques Open
Managing general domain knowledge and asset-specific information in the form of digital representations is especially important and challenging when focusing on long-living and complex assets. Implicit knowledge and existing structures nee…
View article: Towards a method for human-centred analysis of external variety
Towards a method for human-centred analysis of external variety Open
Addressing VUCA challenges in product development, the Human-Centred Analysis of External Variety (HAV) method is introduced. Focusing on the early stages of new product development, HAV provides a structured approach, reducing uncertainty…
View article: Product changes from various viewpoints along the product lifecycle – an empirical study
Product changes from various viewpoints along the product lifecycle – an empirical study Open
From an economic perspective, the appeal of a product diminishes over time. However, volatile markets and divergent technological advancements make it challenging to anticipate when and to what extent changes will be necessary. Therefore, …