Dietmar Fischer
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View article: Cnicin: a promising drug for promoting nerve repair
Cnicin: a promising drug for promoting nerve repair Open
Traumatic peripheral nerve injuries frequently result in irreversible functional deficits. While neurons possess an intrinsic capacity for axonal regeneration, the temporal constraints and the slow pace of neurite outgrowth often impede th…
View article: Enhancing transporter activity in heterologous expression systems with <scp>SAHA</scp> : a 2500‐times more potent and odorless alternative to butyrate
Enhancing transporter activity in heterologous expression systems with <span>SAHA</span> : a 2500‐times more potent and odorless alternative to butyrate Open
The functional characterization of plasma membrane transport proteins often relies on their heterologous expression in cultured cells. However, some transporters exhibit low activity, hindering meaningful functional assays. Heterologous ex…
View article: A CK2α′ mutant indicating why CK2α and CK2α′, the isoforms of the catalytic subunit of human protein kinase CK2, deviate in affinity to CK2β
A CK2α′ mutant indicating why CK2α and CK2α′, the isoforms of the catalytic subunit of human protein kinase CK2, deviate in affinity to CK2β Open
Protein kinase CK2 (casein kinase 2) mainly exists as heterotetrameric holoenzyme with two catalytic subunits (CK2α or CK2α′) bound to a homodimer of non-catalytic subunits (CK2β). With CSNK2A1 and CSNK2A2 , the human genome contains two p…
View article: A creatine efflux transporter in oligodendrocytes
A creatine efflux transporter in oligodendrocytes Open
Creatine is essential for ATP regeneration in energy‐demanding cells. Creatine deficiency results in severe neurodevelopmental impairments. In the brain, creatine is synthesized locally by oligodendrocytes to supply neighboring neurons. Ne…
View article: Cnicin promotes functional nerve regeneration
Cnicin promotes functional nerve regeneration Open
These results highlight the potential of cnicin as a promising drug to treat axonal insults and improve recovery.
View article: Inhibition of tubulin detyrosination: a novel strategy to promote central nervous system regeneration
Inhibition of tubulin detyrosination: a novel strategy to promote central nervous system regeneration Open
The adult mammalian central nervous system (CNS) coordinates essential functions such as sensation, movement, autonomic control, thought processes, and communication. Consequently, injuries or diseases of the CNS are often associated with …
View article: Targeting Vasohibins to Promote Axon Regeneration
Targeting Vasohibins to Promote Axon Regeneration Open
Treatments accelerating axon regeneration in the nervous system are still clinically unavailable. However, parthenolide promotes adult sensory neurons’ axon growth in culture by inhibiting microtubule detyrosination. Here, we show that ove…
View article: Small fibre integrity and axonal pathology in the rat model of experimental autoimmune neuritis
Small fibre integrity and axonal pathology in the rat model of experimental autoimmune neuritis Open
Experimental autoimmune neuritis is a common animal model for acute human immune–mediated polyneuropathies. Although already established in 1955, a number of pathophysiological mechanisms remain unknown. In this study, we extensively chara…
View article: Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration Open
Injured axons in the central nervous system (CNS) usually fail to regenerate, causing permanent disabilities. However, the knockdown of Pten knockout or treatment of neurons with hyper-IL-6 (hIL-6) transforms neurons into a regenerative st…
View article: Author Response: Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
Author Response: Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Metrics Abstract Injured axons …
View article: SLC22A11 Inserts the Uremic Toxins Indoxyl Sulfate and P-Cresol Sulfate into the Plasma Membrane
SLC22A11 Inserts the Uremic Toxins Indoxyl Sulfate and P-Cresol Sulfate into the Plasma Membrane Open
Chronic kidney disease (CKD) is a global health concern affecting millions worldwide. One of the critical challenges in CKD is the accumulation of uremic toxins such as p-cresol sulfate (pCS) and indoxyl sulfate (IS), which contribute to s…
View article: Author Response: Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
Author Response: Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration Open
Injured axons in the central nervous system (CNS) usually fail to regenerate, causing permanent disabilities. However, the knockdown of PTEN or treatment of neurons with hyper-IL-6 (hIL-6) transforms neurons into a regenerative state, allo…
View article: Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration Open
Injured axons in the central nervous system (CNS) usually fail to regenerate, causing permanent disabilities. However, the knockdown of PTEN or treatment of neurons with hyper-IL-6 (hIL-6) transforms neurons into a regenerative state, allo…
View article: Author Response: Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
Author Response: Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration Open
Injured axons in the central nervous system (CNS) usually fail to regenerate, causing permanent disabilities. However, the knockdown of PTEN or treatment of neurons with hyper-IL-6 (hIL-6) transforms neurons into a regenerative state, allo…
View article: Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration Open
Injured axons in the central nervous system (CNS) usually fail to regenerate, causing permanent disabilities. However, the knockdown of Pten knockout or treatment of neurons with hyper-IL-6 (hIL-6) transforms neurons into a regenerative st…
View article: Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration Open
Injured axons in the central nervous system (CNS) usually fail to regenerate, causing permanent disabilities. However, the knockdown of PTEN or treatment of neurons with hyper-IL-6 (hIL-6) transforms neurons into a regenerative state, allo…
View article: Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration Open
Injured axons in the central nervous system (CNS) usually fail to regenerate, causing permanent disabilities. However, the knockdown of PTEN or treatment of neurons with hyper-IL-6 (hIL-6) transforms neurons into a regenerative state, allo…
View article: The Impact of Nε-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2
The Impact of Nε-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2 Open
In addition to the classic functions of proteins, such as acting as a biocatalyst or binding partner, the conformational states of proteins and their remodeling upon stimulation need to be considered. A prominent example of a protein that …
View article: Synthesis and evaluation of radioiodinated estrogens for diagnosis and therapy of male urogenital tumours
Synthesis and evaluation of radioiodinated estrogens for diagnosis and therapy of male urogenital tumours Open
We identified a new estrogen receptor (ER)-targeting ligand with picomolar affinity serving as vehicle for radioiodines. This ligand is a potential radiotheranostics for ER + male tumours.
View article: VASH1/2 inhibition accelerates functional recovery of injured nerves
VASH1/2 inhibition accelerates functional recovery of injured nerves Open
Treatments accelerating axon regeneration in the nervous system are still unavailable in the clinic. However, in culture, parthenolide markedly promotes adult sensory neurons’ axon growth by inhibiting microtubule detyrosination. Here, we …
View article: CXCR4 signaling in central nervous system regeneration: friend or foe?
CXCR4 signaling in central nervous system regeneration: friend or foe? Open
The knockout of the chemokine C-X-C motif chemokine receptor 4 (CXCR4) in growth-stimulated retinal ganglion cells (RGCs) has a multiplicative effect on optic nerve regeneration. C-X-C motif chemokine ligand 12 (CXCL12), the exclusive liga…
View article: Dose-dependent immunomodulatory effects of bortezomib in experimental autoimmune neuritis
Dose-dependent immunomodulatory effects of bortezomib in experimental autoimmune neuritis Open
Proteasome inhibition with bortezomib has been reported to exert an immunomodulatory action in chronic autoimmune neuropathies. However, bortezomib used for the treatment of multiple myeloma induces a painful toxic polyneuropathy at a high…
View article: Transneuronal delivery of designer cytokines: perspectives for spinal cord injury
Transneuronal delivery of designer cytokines: perspectives for spinal cord injury Open
We recently achieved significant functional recovery after a complete spinal cord injury, allowing previously paralyzed mice to walk again. This was accomplished by a single, unilateral application of an adeno-associated virus (AAV) carryi…
View article: CXCR4/CXCL12-mediated entrapment of axons at the injury site compromises optic nerve regeneration
CXCR4/CXCL12-mediated entrapment of axons at the injury site compromises optic nerve regeneration Open
Significance Retinal ganglion cell (RGC) axons in the optic nerve convey visual information from the eye to the brain. Injury causes permanent functional loss as axons cannot regenerate. This failure is generally attributed to an insuffici…
View article: Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis
Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis Open
Chronic disability in multiple sclerosis is linked to neuroaxonal degeneration. 4-aminopyridine (4-AP) is used and licensed as a symptomatic treatment to ameliorate ambulatory disability in multiple sclerosis. The presumed mode of action i…
View article: Transneuronal delivery of designer-cytokine enables functional recovery after complete spinal cord injury
Transneuronal delivery of designer-cytokine enables functional recovery after complete spinal cord injury Open
Spinal cord injury (SCI) often causes severe and permanent disabilities. The current study uses a transneuronal approach to stimulate spinal cord regeneration by AAV-hyper-IL-6 (hIL-6) application after injury. While preinjury PTEN knockou…
View article: GSK3-CRMP2 signaling mediates axonal regeneration induced by Pten knockout
GSK3-CRMP2 signaling mediates axonal regeneration induced by Pten knockout Open
Knockout of phosphatase and tensin homolog (PTEN −/− ) is neuroprotective and promotes axon regeneration in mature neurons. Elevation of mTOR activity in injured neurons has been proposed as the primary underlying mechanism. Here we demons…