Dilara Akbulut
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View article: 1113 TIME_ACT: pan-cancer prediction of tumor immune activation and response to immune checkpoint blockade from tumor transcriptomics and histopathology
1113 TIME_ACT: pan-cancer prediction of tumor immune activation and response to immune checkpoint blockade from tumor transcriptomics and histopathology Open
View article: MEN1-Related Neuroendocrine Tumors Show c-MET Overexpression
MEN1-Related Neuroendocrine Tumors Show c-MET Overexpression Open
Context Approximately 50% to 70% of patients with multiple endocrine neoplasia type 1 (MEN1) die of duodenopancreatic neuroendocrine tumors (NETs). While c-MET inhibitors in combination with antivascular endothelial growth factor therapy h…
View article: Pan-cancer prediction of tumor immune activation and response to immune checkpoint blockade from tumor transcriptomics and histopathology
Pan-cancer prediction of tumor immune activation and response to immune checkpoint blockade from tumor transcriptomics and histopathology Open
Accurately predicting which patients will respond to immune checkpoint blockade (ICB) remains a major challenge. Here, we present TIME_ACT, an unsupervised 66-gene transcriptomic signature of tumor immune activation derived from TCGA melan…
View article: Small cell carcinoma of the bladder: Review of pathogenesis, presentation, and management
Small cell carcinoma of the bladder: Review of pathogenesis, presentation, and management Open
Small cell carcinoma of the bladder (SCCB) is a rare, aggressive malignancy that accounts for less than 1% of all bladder cancers. In this report, we highlight the clinical manifestations of SCCB (including epidemiology, cystoscopic and im…
View article: Characterization of Somatostatin Receptor 2 Gene Expression and Immune Landscape in Sinonasal Malignancies
Characterization of Somatostatin Receptor 2 Gene Expression and Immune Landscape in Sinonasal Malignancies Open
Olfactory neuroblastoma (ONB), sinonasal undifferentiated carcinoma (SNUC), and sinonasal neuroendocrine carcinoma (SNEC) are rare malignancies arising from the sinonasal tract with limited therapeutic options. The expression of the somato…
View article: Molecular Alterations Associated with Histologically Overt Stromal Response in Patients with Prostate Cancer
Molecular Alterations Associated with Histologically Overt Stromal Response in Patients with Prostate Cancer Open
Prostate cancer has substantial heterogeneity in clinical outcomes and therapeutic responses, posing challenges in predicting disease progression and tailoring treatment strategies. Recent studies have highlighted the potential prognostic …
View article: Final Results From a Phase I Trial and Expansion Cohorts of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced/Metastatic Genitourinary Tumors
Final Results From a Phase I Trial and Expansion Cohorts of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced/Metastatic Genitourinary Tumors Open
PURPOSE Cabozantinib and nivolumab (CaboNivo) alone or with ipilimumab (CaboNivoIpi) have shown promising efficacy and safety in patients with metastatic urothelial carcinoma (mUC), metastatic renal cell carcinoma (mRCC), and rare genitour…
View article: Histologically Overt Stromal Response and the Risk of Progression after Radical Prostatectomy for Prostate Cancer
Histologically Overt Stromal Response and the Risk of Progression after Radical Prostatectomy for Prostate Cancer Open
Purpose: Given the variable clinical course of prostate cancer and the limitations of current prognostic factors, this study was conducted to investigate the impact of a histologically overt stromal response (HOST-response) to prostate can…
View article: Mismatch repair deficiency and microsatellite instability in urothelial carcinoma: a systematic review and meta-analysis
Mismatch repair deficiency and microsatellite instability in urothelial carcinoma: a systematic review and meta-analysis Open
Background Mismatch repair deficiency (dMMR) and microsatellite instability-high (MSI-H) occur in a subset of cancers and have been shown to confer sensitivity to immune checkpoint inhibition (ICI); however, there is a lack of prospective …
View article: Updates on Urinary Bladder Tumors With Neuroendocrine Features
Updates on Urinary Bladder Tumors With Neuroendocrine Features Open
The most common neuroendocrine tumor in the urinary bladder is small cell carcinoma, which can be pure or mixed with components of urothelial or other histologic subtypes. Large cell neuroendocrine carcinoma of the bladder is rare and rema…
View article: Prognostic Significance of the Cribriform Pattern in Prostate Cancer: Clinical Outcomes and Genomic Alterations
Prognostic Significance of the Cribriform Pattern in Prostate Cancer: Clinical Outcomes and Genomic Alterations Open
Purpose: Given the diverse clinical progression of prostate cancer (PC) and the evolving significance of histopathological factors in its management, this study aimed to explore the impact of cribriform pattern 4 (CP4) on clinical outcomes…
View article: Protocol for isolation of signet ring cells from human gastric mucosa
Protocol for isolation of signet ring cells from human gastric mucosa Open
More than 90% of individuals with germline pathogenic CDH1 variants will harbor occult, microscopic foci of signet ring cell carcinomas capable of progressing to advanced diffuse-type gastric cancer. Here, we present a protocol for high vi…
View article: Final results from a phase 1 trial and expansion cohorts of cabozantinib and nivolumab alone or with ipilimumab for advanced/metastatic genitourinary tumors
Final results from a phase 1 trial and expansion cohorts of cabozantinib and nivolumab alone or with ipilimumab for advanced/metastatic genitourinary tumors Open
Cabozantinib and nivolumab (CaboNivo) alone or with ipilimumab (CaboNivoIpi) have shown promising efficacy and safety in patients with metastatic urothelial carcinoma (mUC), metastatic renal cell carcinoma (mRCC), and rare genitourinary (G…
View article: Yutma güçlüğüne neden olan retrofarengeal kitle: servikal kordoma
Yutma güçlüğüne neden olan retrofarengeal kitle: servikal kordoma Open
Kordomalar, notokordun embriyolojik artıklarından kaynaklanan nadir primer kemik tümörleridir. Servikal bölge yerleşimli kordomalar oldukça nadir görülmektedir. Tüm kordomaların %5 kadarını oluşturan servikal kordomalar, komşu oldukları pa…