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View article: Defining an NK Cell–enriched Rejection-like Phenotype in Liver Transplant Biopsies From the INTERLIVER Study
Defining an NK Cell–enriched Rejection-like Phenotype in Liver Transplant Biopsies From the INTERLIVER Study Open
Background. Initial analysis of liver transplant biopsies in the INTERLIVER study (ClinicalTrials.gov; unique identifier NCT03193151) using rejection-associated transcripts failed to find an antibody-mediated rejection state (ie, rich in n…
View article: Switching to Tenofovir Therapy Versus Continuation of Entecavir for Patients With Hepatitis B Virus Infection: A Systematic Review and Meta‐Analysis
Switching to Tenofovir Therapy Versus Continuation of Entecavir for Patients With Hepatitis B Virus Infection: A Systematic Review and Meta‐Analysis Open
Background Hepatitis B virus (HBV) infection causes liver disease, including hepatocellular carcinoma. Controlling viral activity is crucial to reducing complications. Tenofovir may offer benefits over entecavir, but it is unclear if switc…
View article: Clinical characteristics of <scp>new‐onset</scp> diabetes after liver transplantation and outcomes
Clinical characteristics of <span>new‐onset</span> diabetes after liver transplantation and outcomes Open
Background We aimed to identify the characteristics of new‐onset diabetes after liver transplantation (LT) (NODAT) and investigate its impacts on post‐transplant outcomes. Methods Adult LT patients between 2014 and 2020 who used tacrolimus…
View article: Disparities in the Effects of Acuity Circle–based Liver Allocation on Waitlist and Transplant Practice Between Centers
Disparities in the Effects of Acuity Circle–based Liver Allocation on Waitlist and Transplant Practice Between Centers Open
Background. Liver allocation in the United States was updated on February 4, 2020, by introducing the acuity circle (AC)–based model. This study evaluated the early effects of the AC-based allocation on waitlist outcomes. Methods. Adult li…
View article: Liver Transplant Recipient Characteristics Associated With Worse Post-Transplant Outcomes in Using Elderly Donors
Liver Transplant Recipient Characteristics Associated With Worse Post-Transplant Outcomes in Using Elderly Donors Open
Advanced age of liver donor is a risk factor for graft loss after transplant. We sought to identify recipient characteristics associated with negative post-liver transplant (LT) outcomes in the context of elderly donors. Using 2014–2019 OP…
View article: Improved Survival With Higher-risk Donor Grafts in Liver Transplant With Acute-on-chronic Liver Failure
Improved Survival With Higher-risk Donor Grafts in Liver Transplant With Acute-on-chronic Liver Failure Open
Background. Use of higher-risk grafts in liver transplantation for patients with acute-on-chronic liver failure (ACLF) has been associated with poor outcomes. This study analyzes trends in liver transplantation outcomes for ACLF over time …
View article: Extreme hyponatremia as a risk factor for early mortality after liver transplantation in the MELD‐sodium era
Extreme hyponatremia as a risk factor for early mortality after liver transplantation in the MELD‐sodium era Open
The impact of hyponatremia on waitlist and post-transplant outcomes following the implementation of MELD-Na-based liver allocation remains unclear. We investigated waitlist and postliver transplant (LT) outcomes in patients with hyponatrem…
View article: MicroRNA-214 enriched exosomes from human cerebral endothelial cells (hCEC) sensitize hepatocellular carcinoma to anti-cancer drugs
MicroRNA-214 enriched exosomes from human cerebral endothelial cells (hCEC) sensitize hepatocellular carcinoma to anti-cancer drugs Open
Hepatocellular carcinoma (HCC) is the most common primary liver tumor worldwide. Current medical therapy for HCC has limited efficacy. The present study tests the hypothesis that human cerebral endothelial cell-derived exosomes carrying el…
View article: Retransplantation outcomes for hepatitis C in the United States before and after direct-acting antiviral introduction
Retransplantation outcomes for hepatitis C in the United States before and after direct-acting antiviral introduction Open
The success of direct-acting antiviral (DAA) therapy has led to near-universal cure for patients chronically infected with hepatitis C virus (HCV) and improved post-liver transplant (LT) outcomes. We investigated the trends and outcomes of…
View article: It Is Not All About Pretransplant Factors: Posttransplant Complications Alter the Risk of Alcohol Relapse
It Is Not All About Pretransplant Factors: Posttransplant Complications Alter the Risk of Alcohol Relapse Open
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View article: A Share 21 model in liver transplantation: Impact on waitlist outcomes
A Share 21 model in liver transplantation: Impact on waitlist outcomes Open
With the introduction of Model for End-Stage Liver Disease-Sodium (MELD-Na)-based allocation, the score at which patients benefit from liver transplantation (LT) has shifted from a score of 15 to 21. This study aimed to evaluate waitlist o…
View article: Inferior Liver Transplant Outcomes in Patients with Nonalcoholic Steatohepatitis
Inferior Liver Transplant Outcomes in Patients with Nonalcoholic Steatohepatitis Open
View article: Effects of Allocating Livers for Transplantation Based on Model for End-Stage Liver Disease–Sodium Scores on Patient Outcomes
Effects of Allocating Livers for Transplantation Based on Model for End-Stage Liver Disease–Sodium Scores on Patient Outcomes Open
View article: Liver alone or simultaneous liver-kidney transplant? Pretransplant chronic kidney disease and post-transplant outcome - a retrospective study
Liver alone or simultaneous liver-kidney transplant? Pretransplant chronic kidney disease and post-transplant outcome - a retrospective study Open
The new Organ Procurement and Transplant Network/United Organ Sharing Network (OPTN/UNOS) simultaneous liver-kidney transplant (SLK) policy has been implemented. The aim of this study was to review liver transplant outcomes utilizing the n…
View article: Novel intraoperative management in the model for end‐stage liver disease–sodium era: Continuous venovenous hemofiltration for severe hyponatremia in liver transplantation
Novel intraoperative management in the model for end‐stage liver disease–sodium era: Continuous venovenous hemofiltration for severe hyponatremia in liver transplantation Open
1Department of Transplant and Hepatobiliary SurgeryHenry Ford HospitalDetroitMI 2Department of GastroenterologyHenry Ford HospitalDetroitMI 3Department of NephrologyHenry Ford HospitalDetroitMI *Address reprint requests to Shunji Nagai, M.…