Dillon C. Adam
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View article: Investigating setting-specific superspreading potential and generation intervals of COVID-19 in Hong Kong
Investigating setting-specific superspreading potential and generation intervals of COVID-19 in Hong Kong Open
Superspreading is an important feature of COVID-19 transmission dynamics, but few studies have investigated this feature stratified by transmission setting. Using detailed clustering data comprising 8647 COVID-19 cases confirmed in Hong Ko…
View article: Integrating Contact Tracing Data to Enhance Outbreak Phylodynamic Inference: A Deep Learning Approach
Integrating Contact Tracing Data to Enhance Outbreak Phylodynamic Inference: A Deep Learning Approach Open
Phylodynamics is central to understanding infectious disease dynamics through the integration of genomic and epidemiological data. Despite advancements, including the application of deep learning to overcome computational limitations, sign…
View article: Insights into COVID-19 epidemiology and control from temporal changes in serial interval distributions in Hong Kong
Insights into COVID-19 epidemiology and control from temporal changes in serial interval distributions in Hong Kong Open
The serial interval (SI) distribution of an epidemic is used to approximate the generation time distribution, an essential parameter for inferring the transmissibility (${R}_t$) of an infectious disease. However, SI distributions may chang…
View article: Investigating setting-specific superspreading potential and generation intervals of COVID-19 in Hong Kong
Investigating setting-specific superspreading potential and generation intervals of COVID-19 in Hong Kong Open
Superspreading is an important feature of SARS-CoV-2, though few studies have investigated quantitatively how transmission characteristics can vary by setting. Using detailed clustering data comprising 8635 SARS-CoV-2 cases confirmed in Ho…
View article: An observational study on imported COVID-19 cases in Hong Kong during mandatory on-arrival hotel quarantine
An observational study on imported COVID-19 cases in Hong Kong during mandatory on-arrival hotel quarantine Open
Testing inbound travellers at arrival and during quarantine can detect imported cases early, but may not prevent all COVID-19 introductions into the community. Public health measures should be adapted in response to the emergence of SARS-C…
View article: Deep learning of SARS-CoV-2 outbreak phylodynamics with contact tracing data
Deep learning of SARS-CoV-2 outbreak phylodynamics with contact tracing data Open
Deep learning has emerged as a powerful tool for phylodynamic analysis, addressing common computational limitations affecting existing methods. However, notable disparities exist between simulated phylogenetic trees used for training exist…
View article: Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong
Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong Open
Hong Kong experienced a surge of Omicron BA.2 infections in early 2022, resulting in one of the highest per-capita death rates of COVID-19. The outbreak occurred in a dense population with low immunity towards natural SARS-CoV-2 infection,…
View article: Residential Clustering of Coronavirus Disease 2019 Cases and Efficiency of Building-Wide Compulsory Testing Notices as a Transmission Control Measure in Hong Kong
Residential Clustering of Coronavirus Disease 2019 Cases and Efficiency of Building-Wide Compulsory Testing Notices as a Transmission Control Measure in Hong Kong Open
We described the frequency of residential case clusters and the efficiency of compulsory testing in identifying cases using buildings targeted in compulsory testing and locally infected coronavirus disease 2019 (COVID-19) cases matched by …
View article: Poliomyelitis Outbreak in Papua New Guinea, 2018
Poliomyelitis Outbreak in Papua New Guinea, 2018 Open
Objective: Vaccine-derived poliovirus (VDPV) remains a significant barrier to global poliomyelitis eradication. Following 18 years of polio-free status, an epidemic of circulating VDPV type 1 (cVDPV1) occurred in Papua New Guinea (PNG) in …
View article: Residential clustering of COVID-19 cases and efficiency of building-wide compulsory testing notices as a transmission control measure in Hong Kong
Residential clustering of COVID-19 cases and efficiency of building-wide compulsory testing notices as a transmission control measure in Hong Kong Open
Background Despite relatively few reports of residential case clusters of COVID-19, building-wide compulsory testing notices on residential apartment blocks are frequently applied in Hong Kong with the aim of identifying cases and reducing…
View article: Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong
Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong Open
After keeping infections at bay for two years, Hong Kong experienced a surge of Omicron BA.2 infections in early 2022 that overwhelmed the health care system, isolation facilities, and contact tracing capacity, leading to one of the highes…
View article: Insights into COVID-19 epidemiology and control from temporal changes in serial interval distributions in Hong Kong
Insights into COVID-19 epidemiology and control from temporal changes in serial interval distributions in Hong Kong Open
The serial interval distribution is used to approximate the generation time distribution, an essential parameter to predict the effective reproductive number “ R t ”, a measure of transmissibility. However, serial interval distributions ma…
View article: An observational study on imported COVID-19 cases in Hong Kong during mandatory on-arrival hotel quarantine
An observational study on imported COVID-19 cases in Hong Kong during mandatory on-arrival hotel quarantine Open
Background Hong Kong has enforced stringent travel restrictions particularly for inbound travellers since the emergence of SARS-CoV-2. Understanding the characteristics of imported COVID-19 cases is important for establishing evidence-base…
View article: Systematic review and meta‐analyses of superspreading of SARS‐CoV‐2 infections
Systematic review and meta‐analyses of superspreading of SARS‐CoV‐2 infections Open
Superspreading, or overdispersion in transmission, is a feature of SARS-CoV-2 transmission which results in surging epidemics and large clusters of infection. The dispersion parameter is a statistical parameter used to characterize and qua…
View article: Genomic epidemiology of seasonal influenza circulation in China during prolonged border closure from 2020 to 2021
Genomic epidemiology of seasonal influenza circulation in China during prolonged border closure from 2020 to 2021 Open
China experienced a resurgence of seasonal influenza activity throughout 2021 despite intermittent control measures and prolonged international border closure. We show genomic evidence for multiple A(H3N2), A(H1N1), and B/Victoria transmis…
View article: Within-hotel transmission of SARS-CoV-2 during on-arrival quarantine in Hong Kong
Within-hotel transmission of SARS-CoV-2 during on-arrival quarantine in Hong Kong Open
Background On-arrival quarantine has been one of the primary measures used to prevent the introduction of COVID-19 into Hong Kong since the start of the pandemic. Most on-arrival quarantines have been done in hotels, with the duration of q…
View article: Reproduction Number of the Omicron Variant Triples That of the Delta Variant
Reproduction Number of the Omicron Variant Triples That of the Delta Variant Open
COVID-19 remains a persistent threat, especially with the predominant Omicron variant emerging in early 2022, presenting with high transmissibility, immune escape, and waning. There is a need to rapidly ramp up global vaccine coverage whil…
View article: Time-varying transmission heterogeneity of SARS and COVID-19 in Hong Kong
Time-varying transmission heterogeneity of SARS and COVID-19 in Hong Kong Open
Transmission heterogeneity is a notable feature of the severe acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19) epidemics, though previous efforts to estimate how heterogeneity changes over time are limited. Using c…
View article: Genomic epidemiology of influenza B circulation in China during prolonged border closure from 2020 to 2021
Genomic epidemiology of influenza B circulation in China during prolonged border closure from 2020 to 2021 Open
China experienced a resurgence of seasonal influenza activity throughout 2021 under intermittent control measures and prolonged international border closure. We show genomic evidence for multiple A(H3N2), A(H1N1), and B/Victoria transmissi…
View article: Superspreading of SARS-CoV-2 infections: A Systematic Review and Meta-analysis
Superspreading of SARS-CoV-2 infections: A Systematic Review and Meta-analysis Open
Superspreading in transmission is a feature of SARS-CoV-2 transmission. We conducted a systematic review and meta-analysis on globally reported dispersion parameters of SARS-CoV-2. The pooled estimate was 0.55 (95% CI: 0.30, 0.79). The stu…
View article: Universal Community Nucleic Acid Testing for Coronavirus Disease 2019 (COVID-19) in Hong Kong Reveals Insights Into Transmission Dynamics: A Cross-Sectional and Modeling Study
Universal Community Nucleic Acid Testing for Coronavirus Disease 2019 (COVID-19) in Hong Kong Reveals Insights Into Transmission Dynamics: A Cross-Sectional and Modeling Study Open
Background Testing of an entire community has been used as an approach to control coronavirus disease 2019 (COVID-19). In Hong Kong, a universal community testing program (UCTP) was implemented at the fadeout phase of a community epidemic …
View article: Air travel-related outbreak of multiple SARS-CoV-2 variants
Air travel-related outbreak of multiple SARS-CoV-2 variants Open
Background A large cluster of 59 cases were linked to a single flight with 146 passengers from New Delhi to Hong Kong in April 2021. This outbreak coincided with early reports of exponential pandemic growth in New Delhi, which reached a pe…
View article: Incorporating temporal distribution of population-level viral load enables real-time estimation of COVID-19 transmissibility
Incorporating temporal distribution of population-level viral load enables real-time estimation of COVID-19 transmissibility Open
Many locations around the world have used real-time estimates of the time-varying effective reproductive number (\({R}_{t}\)) of COVID-19 to provide evidence of transmission intensity to inform control strategies. Estimates of \({R}_{t}\) …
View article: Air travel-related outbreak of multiple SARS-CoV-2 variants
Air travel-related outbreak of multiple SARS-CoV-2 variants Open
Background A large cluster of 59 cases were linked to a single flight with 146 passengers from New Delhi to Hong Kong in April 2021. This outbreak coincided with early reports of exponential pandemic growth in New Delhi, which reached a pe…