Dillon E. King
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View article: Mitochondrial DNA Replication and Disease: A Historical Perspective on Molecular Insights and Therapeutic Advances
Mitochondrial DNA Replication and Disease: A Historical Perspective on Molecular Insights and Therapeutic Advances Open
Mitochondria are vital for cellular energy production, as these organelles generate most of the cellular energy required for various metabolic processes. Mitochondria contain their own circular DNA, which is present in multiple copies and …
View article: Environmental Toxicology: How Pollutants Like Lead Impact Our Health
Environmental Toxicology: How Pollutants Like Lead Impact Our Health Open
Every day, we interact with our environments. Many things in our environments are safe, but some might make us sick. How do scientists figure out which things make us sick? And when we find out what makes people sick, how do we clean up th…
View article: UV irradiation alters TFAM binding to mitochondrial DNA
UV irradiation alters TFAM binding to mitochondrial DNA Open
Mitochondria lack nucleotide excision repair; however, mitochondrial DNA (mtDNA) is resistant to mutation accumulation following DNA damage. These observations suggest additional damage sensing or protection mechanisms. Transcription Facto…
View article: The use of race terms in epigenetics research: considerations moving forward
The use of race terms in epigenetics research: considerations moving forward Open
The field of environmental epigenetics is uniquely suited to investigate biologic mechanisms that have the potential to link stressors to health disparities. However, it is common practice in basic epigenetic research to treat race as a co…
View article: rol-6 and dpy-10 C. elegans mutants have normal mitochondrial function after normalizing to delayed development
rol-6 and dpy-10 C. elegans mutants have normal mitochondrial function after normalizing to delayed development Open
Collagen mutations are commonly used in the creation of Caenorhabditis elegans transgenic strains, but their secondary effects are not fully characterized. We compared the mitochondrial function of N2, dpy-10, rol-6, and PE255 C. elegans. …
View article: Increased cytotoxicity of Pb<sup>2+</sup> with co-exposures to a mitochondrial uncoupler and mitochondrial calcium uniporter inhibitor
Increased cytotoxicity of Pb<sup>2+</sup> with co-exposures to a mitochondrial uncoupler and mitochondrial calcium uniporter inhibitor Open
Mixtures of Pb 2+ and two mechanistically distinct mitochondrial toxicants, ruthenium red and carbonyl cyanide- p -trifluoromethoxyphenylhydrazone (FCCP), resulted in greater than additive Pb 2+ -induced cytotoxicity in HepG2 (human liver)…
View article: CUREing Biochemistry Lab Monotony
CUREing Biochemistry Lab Monotony Open
Undergraduate research experience is critical to success in post-graduate research settings. The recent movement away from "cookbook" style labs to course-based undergraduate research experiences (CUREs) in undergraduate laboratories has a…
View article: The Inclusion of Sex and Gender Beyond the Binary in Toxicology
The Inclusion of Sex and Gender Beyond the Binary in Toxicology Open
OPINION article Front. Toxicol., 22 July 2022Sec. Regulatory Toxicology https://doi.org/10.3389/ftox.2022.929219
View article: Cannabis alters DNA methylation at maternally imprinted and autism candidate genes in spermatogenic cells
Cannabis alters DNA methylation at maternally imprinted and autism candidate genes in spermatogenic cells Open
Cannabis use in the United States is increasing, with highest consumption among men at their peak reproductive years. We previously demonstrated widespread changes in sperm DNA methylation with cannabis exposure in humans and rats, includi…
View article: Sex-specific DNA methylation and associations with <i>in utero</i> tobacco smoke exposure at nuclear-encoded mitochondrial genes
Sex-specific DNA methylation and associations with <i>in utero</i> tobacco smoke exposure at nuclear-encoded mitochondrial genes Open
Sex-linked differences in mitochondrial ATP production, enzyme activities, and reactive oxygen species generation have been reported in multiple tissue and cell types. While the effects of reproductive hormones underlie many of these diffe…
View article: Data from: Sex-specific dna methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes
Data from: Sex-specific dna methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes Open
Sex-linked differences in mitochondrial ATP production, enzyme activities, and reactive oxygen species generation have been reported in multiple tissue and cell types. While the effects of reproductive hormones underlie many of these diffe…
View article: Sex-specific DNA methylation and associations with <i>in utero</i> tobacco smoke exposure at nuclear-encoded mitochondrial genes
Sex-specific DNA methylation and associations with <i>in utero</i> tobacco smoke exposure at nuclear-encoded mitochondrial genes Open
Sex-linked differences in mitochondrial ATP production, enzyme activities, and reactive oxygen species generation have been reported in multiple tissue and cell types. While the effects of reproductive hormones underlie many of these diffe…
View article: Refraining from use diminishes cannabis-associated epigenetic changes in human sperm
Refraining from use diminishes cannabis-associated epigenetic changes in human sperm Open
Cannabis use alters sperm DNA methylation, but the potential reversibility of these changes is unknown. Semen samples from cannabis users and non-user controls were collected at baseline and again following a 77-day period of cannabis abst…
View article: Xenobiotic metabolism and transport in <i>Caenorhabditis elegans</i>
Xenobiotic metabolism and transport in <i>Caenorhabditis elegans</i> Open
Caenorhabditis elegans has emerged as a major model in biomedical and environmental toxicology. Numerous papers on toxicology and pharmacology in C. elegans have been published, and this species has now been adopted by investigators in aca…
View article: Proteasome Inhibition in Brassica napus Roots Increases Amino Acid Synthesis to Offset Reduced Proteolysis
Proteasome Inhibition in Brassica napus Roots Increases Amino Acid Synthesis to Offset Reduced Proteolysis Open
Cellular homeostasis is maintained by the proteasomal degradation of regulatory and misfolded proteins, which sustains the amino acid pool. Although proteasomes alleviate stress by removing damaged proteins, mounting evidence indicates tha…