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View article: Lipid Metabolism–Signaling Crosstalk in Metabolic Disease and Aging: Mechanisms and Therapeutic Targets
Lipid Metabolism–Signaling Crosstalk in Metabolic Disease and Aging: Mechanisms and Therapeutic Targets Open
Lipid metabolism and lipid-derived signaling together ensure cellular and systemic homeostasis. Their dysregulation causes obesity, type 2 diabetes, cardiovascular disease, NAFLD/MASH, and neurodegeneration throughout life. This review int…
View article: SAT-307 Drug-like ADME Profiles and Antimetastatic Properties of Monocarbonyl Curcumin Analogs C66 and B2BrBC with Improved Stability
SAT-307 Drug-like ADME Profiles and Antimetastatic Properties of Monocarbonyl Curcumin Analogs C66 and B2BrBC with Improved Stability Open
Disclosure: R. Stojchevski: None. E. Sutanto: None. K. Dragarska: None. I. Todorovska: None. S. Velichkovikj: None. N. Hadzi-Petrushev: None. J. Bogdanov: None. M. Mladenov: None. L. Poretsky: None. D.B. Avtanski: None. Monocarbonyl analog…
View article: Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes
Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes Open
Cancer is complex because of the critical imbalance in genetic regulation as characterized by both the overexpression of oncogenes (OGs), mainly through mutations, amplifications, and translocations, and the inactivation of tumor-suppresso…
View article: Translational Advances in Oncogene and Tumor-Suppressor Gene Research
Translational Advances in Oncogene and Tumor-Suppressor Gene Research Open
Cancer, characterized by the uncontrolled proliferation of cells, is one of the leading causes of death globally, with approximately one in five people developing the disease in their lifetime. While many driver genes were identified decad…
View article: 6603 Impact Of The Monocarbonyl Analogs Of Curcumin, C66 And B2BrBC, On The Protein Expression Of Epithelial And Mesenchymal Markers In MCF-7 Breast Cancer Cells
6603 Impact Of The Monocarbonyl Analogs Of Curcumin, C66 And B2BrBC, On The Protein Expression Of Epithelial And Mesenchymal Markers In MCF-7 Breast Cancer Cells Open
Disclosure: R. Stojchevski: None. A. Lavi: None. J. Bogdanov: None. N. Hadzi-Petrushev: None. M. Mladenov: None. L. Poretsky: None. D.B. Avtanski: None. The synthesis of monocarbonyl analogs of curcumin (MACs) presents a solution to the ch…
View article: 6603 Impact of the Monocarbonyl Analogs of Curcumin, C66 and B2BrBC, on the Protein Expression of Epithelial and Mesenchymal Markers in MCF-7 Breast Cancer Cells
6603 Impact of the Monocarbonyl Analogs of Curcumin, C66 and B2BrBC, on the Protein Expression of Epithelial and Mesenchymal Markers in MCF-7 Breast Cancer Cells Open
Disclosure: R. Stojchevski: None. A. Lavi: None. J. Bogdanov: None. N. Hadzi-Petrushev: None. M. Mladenov: None. L. Poretsky: None. D.B. Avtanski: None. The synthesis of monocarbonyl analogs of curcumin (MACs) presents a solution to the ch…
View article: Impact of monocarbonyl analogs of curcumin (MACs) C66 and B2BrBC on the expression of diabetes-associated genes in streptozotocin-treated rat pancreatic RIN-m cells—Quantitative RT-PCR array data
Impact of monocarbonyl analogs of curcumin (MACs) C66 and B2BrBC on the expression of diabetes-associated genes in streptozotocin-treated rat pancreatic RIN-m cells—Quantitative RT-PCR array data Open
This paper presents a dataset obtained from an RT2-qPCR array analysis of rat pancreatic RIN-m cells treated with two monocarbonyl analogs of curcumin (MACs), C66 and B2BrBC in the presence or absence of streptozotocin (STZ). Th…
View article: Monocarbonyl analogs of curcumin C66 and B2BrBC modulate oxidative stress, JNK activity, and pancreatic gene expression in rats with streptozotocin-induced diabetes
Monocarbonyl analogs of curcumin C66 and B2BrBC modulate oxidative stress, JNK activity, and pancreatic gene expression in rats with streptozotocin-induced diabetes Open
The pathogenesis of type 1 diabetes mellitus (T1DM) involves oxidative stress and inflammation. Curcumin, a natural polyphenolic compound found in turmeric, known to exhibit antioxidative and anti-inflammatory properties, is characterized …
View article: GLUT5-overexpression-related tumorigenic implications
GLUT5-overexpression-related tumorigenic implications Open
View article: Adipose Tissue Dysfunction Related to Climate Change and Air Pollution: Understanding the Metabolic Consequences
Adipose Tissue Dysfunction Related to Climate Change and Air Pollution: Understanding the Metabolic Consequences Open
Obesity, a global pandemic, poses a major threat to healthcare systems worldwide. Adipose tissue, the energy-storing organ during excessive energy intake, functions as a thermoregulator, interacting with other tissues to regulate systemic …
View article: Protective Effects of Resveratrol Against Airway Hyperreactivity, Oxidative Stress, and Lung Inflammation in a Rat Pup Model of Bronchopulmonary Dysplasia
Protective Effects of Resveratrol Against Airway Hyperreactivity, Oxidative Stress, and Lung Inflammation in a Rat Pup Model of Bronchopulmonary Dysplasia Open
Oxygen therapy provides an important treatment for preterm and low-birth-weight neonates, however, it has been shown that prolonged exposure to high levels of oxygen (hyperoxia) is one of the factors contributing to the development of bron…
View article: The effect of resistin on the redox state of breast cancer cells
The effect of resistin on the redox state of breast cancer cells Open
View article: The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential
The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential Open
A growing body of evidence has demonstrated a relationship between the microbiome, adiposity, and cancer development. The microbiome is emerging as an important factor in metabolic disease and cancer pathogenesis. This review aimed to high…
View article: Anticarcinogenic Potency of EF24: An Overview of Its Pharmacokinetics, Efficacy, Mechanism of Action, and Nanoformulation for Drug Delivery
Anticarcinogenic Potency of EF24: An Overview of Its Pharmacokinetics, Efficacy, Mechanism of Action, and Nanoformulation for Drug Delivery Open
EF24, a synthetic monocarbonyl analog of curcumin, shows significant potential as an anticancer agent with both chemopreventive and chemotherapeutic properties. It exhibits rapid absorption, extensive tissue distribution, and efficient met…
View article: THU557 Effects Of Two Experimental Monocarbonyl Analogs Of Curcumin (MACs) On Breast Cancer Growth, Migration, And Epithelial-To-Mesenchymal Transition (EMT)
THU557 Effects Of Two Experimental Monocarbonyl Analogs Of Curcumin (MACs) On Breast Cancer Growth, Migration, And Epithelial-To-Mesenchymal Transition (EMT) Open
Disclosure: R. Stojchevski: None. N. Hadzi-Petrushev: None. M. Mladenov: None. J. Bogdanov: None. S. Velichkovikj: None. L. Poretsky: None. D.B. Avtanski: None. Curcumin, a polyphenol found in turmeric (Curcuma longa), has been reported to…
View article: Emerging technologies in adipose tissue research
Emerging technologies in adipose tissue research Open
Technologies are transforming the understanding of adipose tissue as a complex and dynamic tissue that plays a critical role in energy homoeostasis and metabolic health. This mini-review provides a brief overview of the potential impact of…
View article: Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging
Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging Open
This review is focused on the mechanisms that regulate health, disease and aging redox status, the signal pathways that counteract oxidative and reductive stress, the role of food components and additives with antioxidant properties (curcu…
View article: Positive Tetrahydrocurcumin-Associated Brain-Related Metabolomic Implications
Positive Tetrahydrocurcumin-Associated Brain-Related Metabolomic Implications Open
Tetrahydrocurcumin (THC) is a metabolite of curcumin (CUR). It shares many of CUR’s beneficial biological activities in addition to being more water-soluble, chemically stable, and bioavailable compared to CUR. However, its mechanisms of a…
View article: The effects of irisin and leptin on steroidogenic enzyme gene expression in human granulosa cells: In vitro studies
The effects of irisin and leptin on steroidogenic enzyme gene expression in human granulosa cells: In vitro studies Open
View article: C66 and B2brbc Modulate Oxidative Stress, Jnk Activity, and Pancreatic Gene Expression In Rats with Streptozotocin-Induced Diabetes
C66 and B2brbc Modulate Oxidative Stress, Jnk Activity, and Pancreatic Gene Expression In Rats with Streptozotocin-Induced Diabetes Open
View article: PMON211 Energy metabolism hormones irisin and leptin affect steroidogenesis in human granulosa cells: in vitro studies
PMON211 Energy metabolism hormones irisin and leptin affect steroidogenesis in human granulosa cells: in vitro studies Open
Energy metabolism and reproduction are closely linked; however, the role of the individual energy metabolism hormones in this association is still poorly understood. Irisin is a hormone produced mostly by skeletal muscle cells during exerc…
View article: Efficacy of the monocarbonyl curcumin analog C66 in the reduction of diabetes-associated cardiovascular and kidney complications
Efficacy of the monocarbonyl curcumin analog C66 in the reduction of diabetes-associated cardiovascular and kidney complications Open
Curcumin is a polyphenolic compound derived from turmeric that has potential beneficial properties for cardiovascular and renal diseases and is relatively safe and inexpensive. However, the application of curcumin is rather problematic due…
View article: Antibacterial and Antiviral Properties of Tetrahydrocurcumin-Based Formulations: An Overview of Their Metabolism in Different Microbiotic Compartments
Antibacterial and Antiviral Properties of Tetrahydrocurcumin-Based Formulations: An Overview of Their Metabolism in Different Microbiotic Compartments Open
In this review, the basic metabolic characteristics of the curcuminoid tetrahydrocurcumin (THC) at the level of the intestinal microbiota were addressed. Special attention was given to the bactericidal effects of one of the THC-phospholipi…
View article: Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study
Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study Open
This study aimed to evaluate the cardioprotective effects of L-2-oxothiazolidine-4-carboxylate (OTC) against isoproterenol (ISO)-induced acute myocardial infarction (MI) in rats. Results demonstrated that OTC treatments inhibited ISO-induc…
View article: Tetrahydrocurcumin-Related Vascular Protection: An Overview of the Findings from Animal Disease Models
Tetrahydrocurcumin-Related Vascular Protection: An Overview of the Findings from Animal Disease Models Open
Tetrahydrocurcumin (THC), one of the major metabolites of CUR, possesses several CUR-like pharmacological effects; however, its mechanisms of action are largely unknown. This manuscript aims to summarize the literature on the preventive ro…
View article: In vitro treatment of human granulosa cells with irisin and leptin: Quantitative RT-PCR array data (female infertility panel)
In vitro treatment of human granulosa cells with irisin and leptin: Quantitative RT-PCR array data (female infertility panel) Open
Reproduction is closely related to energy metabolism: physical activity and adiposity (either insufficient weight or obesity) can affect female fertility. Irisin is a myo- and adipokine produced by skeletal muscles during exercise or shive…
View article: Evaluation of the in vitro effects of irisin and leptin on human ovarian granulosa cells – PCR array data (female infertility panel)
Evaluation of the in vitro effects of irisin and leptin on human ovarian granulosa cells – PCR array data (female infertility panel) Open
Human ovarian granulosa cells were purified from follicular fluid samples obtained from patients undergoing in vitro fertilization procedure by using Percoll PLUS reagent (GE Healthcare, Cat. # 17-5445-02). Cells were grown in DMEM/F12 (50…
View article: Hyperleptinemia in obese state renders luminal breast cancers refractory to tamoxifen by coordinating a crosstalk between Med1, miR205 and ErbB
Hyperleptinemia in obese state renders luminal breast cancers refractory to tamoxifen by coordinating a crosstalk between Med1, miR205 and ErbB Open
View article: The Effects of Leptin and Irisin on Steroidogenic Enzyme Gene Expression in Human Ovarian Granulosa Cells - Initial Studies
The Effects of Leptin and Irisin on Steroidogenic Enzyme Gene Expression in Human Ovarian Granulosa Cells - Initial Studies Open
Fertility and energy metabolism are closely associated, and the cytokines produced by the adipose and muscle tissue play a role in this association. Leptin, predominantly produced by the white adipose tissue, and irisin, produced by the br…