Dimitri Cadet
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View article: STEM-23. GBM NEURODEVELOPMENTAL LINEAGE PLASTICITY DRIVES RAPID ADAPTATION TO ONCOGENE TARGETED THERAPY
STEM-23. GBM NEURODEVELOPMENTAL LINEAGE PLASTICITY DRIVES RAPID ADAPTATION TO ONCOGENE TARGETED THERAPY Open
Phenotypic plasticity plays a pivotal role in cancer, enabling tumor cells to adapt to environmental pressures and evade therapeutic interventions by transitioning between distinct cellular states. However, the contribution of phenotypic p…
View article: EPCO-63. LIPID METABOLIC HETEROGENEITY ACROSS GLIOMA CELLULAR STATES REVEALS ENVIRONMENTAL DEPENDENCIES
EPCO-63. LIPID METABOLIC HETEROGENEITY ACROSS GLIOMA CELLULAR STATES REVEALS ENVIRONMENTAL DEPENDENCIES Open
Gliomas are lethal malignancies composed of heterogeneous and dynamic subpopulations of cellular states that resemble both normal neurodevelopmental cell types and adaptive responses to stress within the tumor microenvironment (TME). While…
View article: DDDR-57. A brain-penetrant EGFR inhibitor overcomes EGFR variant heterogeneity in glioblastoma
DDDR-57. A brain-penetrant EGFR inhibitor overcomes EGFR variant heterogeneity in glioblastoma Open
The epidermal growth factor receptor (EGFR) is one of the most frequently altered genes in glioblastoma (GBM), yet therapeutic efforts have been limited by the heterogeneity of EGFR variants and poor blood–brain barrier permeability. We de…
View article: TMET-40. Proneural Glioblastomas Exhibit Altered Lipid Metabolism That Promotes Susceptibility to Non-Canonical Cell Death
TMET-40. Proneural Glioblastomas Exhibit Altered Lipid Metabolism That Promotes Susceptibility to Non-Canonical Cell Death Open
Glioblastomas (GBMs) are highly resistant to therapies (e.g., radiation, chemotherapy therapy) targeting canonical apoptotic pathways. Emerging evidence suggests that non-canonical, lipid-mediated cell death mechanisms - such as ferroptosi…
View article: CNSC-84. GLIOBLASTOMA HIJACKS NEURONAL MECHANISMS TO EVADE APOPTOSIS
CNSC-84. GLIOBLASTOMA HIJACKS NEURONAL MECHANISMS TO EVADE APOPTOSIS Open
Infiltration and integration of cancer cells into normal brain structures is a hallmark of glioblastoma (GBM) and contributes to both the high recurrence rates and the limited efficacy of current therapies. Recent studies have shown that g…
View article: TMET-40. Proneural Glioblastomas Exhibit Altered Lipid Metabolism That Promotes Susceptibility to Non-Canonical Cell Death
TMET-40. Proneural Glioblastomas Exhibit Altered Lipid Metabolism That Promotes Susceptibility to Non-Canonical Cell Death Open
Glioblastomas (GBMs) are highly resistant to therapies (e.g., radiation, chemotherapy therapy) targeting canonical apoptotic pathways. Emerging evidence suggests that non-canonical, lipid-mediated cell death mechanisms - such as ferroptosi…
View article: CNSC-84. GLIOBLASTOMA HIJACKS NEURONAL MECHANISMS TO EVADE APOPTOSIS
CNSC-84. GLIOBLASTOMA HIJACKS NEURONAL MECHANISMS TO EVADE APOPTOSIS Open
Infiltration and integration of cancer cells into normal brain structures is a hallmark of glioblastoma (GBM) and contributes to both the high recurrence rates and the limited efficacy of current therapies. Recent studies have shown that g…
View article: Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma
Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma Open
Genomic profiling often fails to predict therapeutic outcomes in cancer. This failure is, in part, due to a myriad of genetic alterations and the plasticity of cancer signaling networks. Functional profiling, which ascertains signaling dyn…
View article: Glioblastoma Neurovascular Progenitor Orchestrates Tumor Cell Type Diversity
Glioblastoma Neurovascular Progenitor Orchestrates Tumor Cell Type Diversity Open
Glioblastoma (GBM) is the deadliest form of primary brain tumor with limited treatment options. Recent studies have profiled GBM tumor heterogeneity, revealing numerous axes of variation that explain the molecular and spatial features of t…