Dimitri G. Trembath YOU? Author Swipe

Last 10y

An <i>ex vivo</i> functional biomarker of treatment response in pediatric low-grade glioma Open

Nichole Artz, Breanna Mann, Aaron Ebbs, Rami Darawsheh, Rajaneekar Dasari , et al. · 2025

Background Children with subtotally resected pediatric low-grade glioma (pLGG) often face multiple lines of treatment, which are seldom capable of eliminating the entire tumor. Genomics-based biomarkers are often used to select targeted th…

Purity Independent Subtyping of Tumors (PurIST) Pancreatic Cancer Classifier Open

Yan Li, Jason D. Merker, Rachana Kshatriya, Dimitri G. Trembath, Ashley B. Morrison , et al. · 2024

Colonic epithelial miR-31 associates with the development of Crohn's phenotypes Open

Benjamin P. Keith, Jasmine Barrow, Takahiko Toyonaga, Nevzat Kazgan, Michelle Hoffner O’Connor , et al. · 2024

BACKGROUND: Crohn's disease (CD) is highly heterogeneous, due in large part to variability in cellular processes that underlie the natural history of CD, thereby confounding effective therapy. There is a critical need to advance understand…

Endoscopic ultrasound-guided fine needle biopsy through the interstices of a colonic stent for the diagnosis of metastatic breast cancer using a forward-viewing linear echoendoscope Open

Woojin Jeong, Dimitri G. Trembath, Todd H. Baron · 2024

Malignancies of extracolonic origin can be the cause of colorectal obstruction. Acute colorectal obstruction generally requires rapid decompression. Self-expandable metal stent (SEMS) placement is a nonsurgical alternative for palliation o…

Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth Open

Danielle Cook, Melissa Kang, T. D. Martin, J.A Galanko, Gabriela Herrera Loeza , et al. · 2024

ECT2 is an activator of RHO GTPases that is essential for cytokinesis. In addition, ECT2 was identified as an oncoprotein when expressed ectopically in NIH/3T3 fibroblasts. However, oncogenic activation of ECT2 resulted from N-terminal tru…

Increased tryptophan, but not increased glucose metabolism, predict resistance of pembrolizumab in stage III/IV melanoma Open

Jorge D. Oldan, Benjamin Giglio, Eric S. Smith, Weiling Zhao, Deeanna M. Bouchard , et al. · 2023

Clinical trials of combined IDO/PD1 blockade in metastatic melanoma (MM) failed to show additional clinical benefit compared to PD1-alone inhibition. We reasoned that a tryptophan-metabolizing pathway other than the kynurenine one is essen…

Supplementary Figures from Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth Open

Danielle Cook, Melissa Kang, Timothy D. Martin, Joseph A. Galanko, Gabriela H. Loeza , et al. · 2023

Supplementary Figures S1-S4

Supplementary Figures from Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth Open

Danielle Cook, Melissa Kang, Timothy D. Martin, Joseph A. Galanko, Gabriela H. Loeza , et al. · 2023

Supplementary Figures S1-S4

Supplementary Data from Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth Open

Danielle Cook, Melissa Kang, Timothy D. Martin, Joseph A. Galanko, Gabriela H. Loeza , et al. · 2023

Supplementary Tables and Methods.

Data from Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth Open

Danielle Cook, Melissa Kang, Timothy D. Martin, Joseph A. Galanko, Gabriela H. Loeza , et al. · 2023

ECT2 is an activator of RHO GTPases that is essential for cytokinesis. In addition, ECT2 was identified as an oncoprotein when expressed ectopically in NIH/3T3 fibroblasts. However, oncogenic activation of ECT2 resulted from N-terminal tru…

Supplementary Data from Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth Open

Danielle Cook, Melissa Kang, Timothy D. Martin, Joseph A. Galanko, Gabriela H. Loeza , et al. · 2023

Supplementary Tables and Methods.

Data from Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth Open

Danielle Cook, Melissa Kang, Timothy D. Martin, Joseph A. Galanko, Gabriela H. Loeza , et al. · 2023

ECT2 is an activator of RHO GTPases that is essential for cytokinesis. In addition, ECT2 was identified as an oncoprotein when expressed ectopically in NIH/3T3 fibroblasts. However, oncogenic activation of ECT2 resulted from N-terminal tru…

Impact of prior systemic therapy on lymphocytic infiltration in surgically resected breast cancer brain metastases Open

Sonya Chew, Andrew Bacotti, Y. Chen, Carey K. Anders, Maria J. Sambade , et al. · 2023

Increased Tryptophan, But Not Increased Glucose Metabolism, Predict Resistance of Pembrolizumab in Stage III/IV Melanoma Open

Jorge D. Oldan, Benjamin Giglio, Eric S. Smith, Weiling Zhao, Deeanna M. Bouchard , et al. · 2022

Clinical trials of combined IDO/PD1 blockade in metastatic melanoma (MM) failed to show additional clinical benefit compared to PD1-alone inhibition. We reasoned that a tryptophan-metabolizing pathway other than the kynurenine one is essen…

Clinical Laboratory Testing Practices in Diffuse Gliomas Prior to Publication of 2021 World Health Organization Classification of Central Nervous System Tumors Open

Shakti Ramkissoon, Helen Fernandes, Dolores López‐Terrada, Meera Hameed, Dimitri G. Trembath , et al. · 2022

Context.— Integration of molecular data into glioma classification supports diagnostic, prognostic, and therapeutic decision-making; however, testing practices for these informative biomarkers in clinical laboratories remain unclear. Objec…

The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma Open

Georgia Sofia Karachaliou, Rached Alkallas, Sarah B. Carroll, Chongshan Caressi, Danny Zakria , et al. · 2022

Rectal carcinoma arising in a patient with intestinal and hepatic schistosomiasis due to Schistosoma mekongi Open

Matthew J Burky, Dimitri G. Trembath, Christine Bookhout · 2022

Schistosomiasis is a parasitic trematode infection spread by snails with multiple species causing human disease. Infection can cause liver disease, including fibrosis and portal hypertension, and has been linked to malignancies such as bla…

Additional file 2 of The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma Open

Georgia Sofia Karachaliou, Rached Alkallas, Sarah B. Carroll, Chongshan Caressi, Danny Zakria , et al. · 2022

Additional file 2. Individual Patient Data for the UNC-CH/Vanderbilt/California Pacific Medical Research Institute. Abbreviations: F, female; M, male; MM, metastatic melanoma; f/u, follow-up; immunotx, immunotherapy; n/a, non applicable; n…

Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth Open

Danielle Cook, Melissa Kang, Timothy D. Martin, Joseph A. Galanko, Gabriela Herrera Loeza , et al. · 2021

ECT2 is an activator of RHO GTPases that is essential for cytokinesis. In addition, ECT2 was identified as an oncoprotein when expressed ectopically in NIH/3T3 fibroblasts. However, oncogenic activation of ECT2 resulted from N-terminal tru…

Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer Open

Tara Williamson, Michelle Carvalho de Abreu, Dimitri G. Trembath, Cory Brayton, Byunghak Kang , et al. · 2021

The five-year survival rate for metastatic pancreatic cancer is currently only 3%, which increases to 13% with local invasion only and to 39% with localized disease at diagnosis. Here we evaluated repurposed mebendazole, an approved anthel…

Melanoma-specific expression of the tumor suppressor proteins p16 and PTEN is a favorable prognostic factor in established melanoma brain metastases Open

Dimitri G. Trembath, Anastasia Ivanova, Michal T. Krauze, John M. Kirkwood, Nana Nikolaishvilli-Feinberg , et al. · 2021

PTEN and p16 frequently undergo (epi)genetic aberrations in melanoma resulting in decreased, or absent, protein levels. We investigated the prognostic significance of these tumor suppressor genes in melanoma brain metastases (MBMs). Immuno…

Brain Tumor Microenvironment and Angiogenesis in Melanoma Brain Metastases Open

Dimitri G. Trembath, Eric S. Davis, Shanti Rao, Evan Bradler, Angelica F. Saada , et al. · 2021

Background High tumor-infiltrating lymphocytes (TILs) and hemorrhage are important prognostic factors in patients who have undergone craniotomy for melanoma brain metastases (MBM) before 2011 at the University of Pittsburgh Medical Center …

MERTK receptor tyrosine kinase is a therapeutic target in melanoma Open

Jennifer Schlegel, Maria J. Sambade, Susan Sather, Stergios J. Moschos, Aik Choon Tan , et al. · 2020

Metastatic melanoma is one of the most aggressive forms of cutaneous cancers. Although recent therapeutic advances have prolonged patient survival, the prognosis remains dismal. C-MER proto-oncogene tyrosine kinase (MERTK) is a receptor ty…

Current Developments in the Genetics of Autism: From Phenome to Genome Open

Molly Losh, Patrick F. Sullivan, Dimitri G. Trembath, Joseph Piven · 2020

Despite compelling evidence from twin and family studies indicating a strong genetic involvement in the etiology of autism, the unequivocal detection of autism susceptibility genes remains an elusive goal. The purpose of this review is to …

MicroRNAs Classify Different Disease Behavior Phenotypes of Crohnʼs Disease and May Have Prognostic Utility: Open

Bailey C. E. Peck, Matthew Weiser, Saangyoung E. Lee, Gregory R. Gipson, Vishal B. Iyer , et al. · 2020

Article first published online 6 July 2015.Supplemental Digital Content is Available in the Text.Background:There is a dire need for reliable prognostic markers that can guide effective therapeutic intervention in Crohn's disease (CD). We …

Detection of Dysplasia in Barrett's Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements Open

Neil G. Terry, Yizheng Zhu, Matthew T. Rinehart, William J. Brown, Steven C. Gebhart , et al. · 2020

Patients with Barrett’s esophagus (BE) show increased risk for developing esophageal adenocarcinoma and are routinely examined using upper endoscopy with biopsy to search for neoplastic changes. Angle-resolved low coherence interferometry …

Olfactory neuroblastoma pulmonary metastasis presenting as a solitary pulmonary mass in an adult: A case report with pathologic correlation Open

Thangavijayan Bosemani, Dimitri G. Trembath · 2020

Clinicopathologic and molecular features of intracranial desmoplastic small round cell tumors Open

Julieann C. Lee, Javier Villanueva-Meyer, Sean P. Ferris, Elaine Cham, Jacob Zucker , et al. · 2019

Desmoplastic small round cell tumors (DSRCTs) are highly aggressive sarcomas that most commonly occur intra‐abdominally, and are defined by EWSR1 ‐ WT1 gene fusion. Intracranial DSRCTs are exceptionally rare with only seven previously repo…

Metastatic melanoma in an esophagus demonstrating Barrett esophagus with high grade dysplasia Open

Dimitri G. Trembath, Nicholas J. Shaheen, Stacey S. O’Neill, Karen E. Weck, Kevin G. Greene · 2019

Background Metastatic melanoma involving the esophagus is rare; the occurrence of metastatic melanoma in a background of Barrett esophagus is rarer still. We report a case of an 80 year-old male who presented to our institution for workup …

Fetching topic information...