Dimitrios Parissis
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View article: Prescription Drug Use in NMOSD: A Population-Based Study in Greece with Estimation of National Disease Administrative Prevalence
Prescription Drug Use in NMOSD: A Population-Based Study in Greece with Estimation of National Disease Administrative Prevalence Open
Background/Objectives: Neuromyelitis Optica Spectrum disorder (NMOSD) is a rare, autoimmune disease of the central nervous system with a globally heterogeneous prevalence/ To estimate the prescription-based prevalence of NMOSD in Greece an…
View article: Greek Registry for Amyotrophic Lateral Sclerosis (ALS‐GR): An Observational Cohort of Individuals With ALS Across 11 Specialized Centers in Greece
Greek Registry for Amyotrophic Lateral Sclerosis (ALS‐GR): An Observational Cohort of Individuals With ALS Across 11 Specialized Centers in Greece Open
Background Epidemiological studies on amyotrophic lateral sclerosis (ALS) in Greece are scarce and outdated. Methods We performed an observational cohort study in 11 specialized centres across Greece. Adult individuals with ALS diagnosed b…
View article: Subunit-Specific Immunodominance in Clinically Distinct Populations With AChR+ Myasthenia Gravis
Subunit-Specific Immunodominance in Clinically Distinct Populations With AChR+ Myasthenia Gravis Open
Two distinct MG endotypes emerge based on sex, age, thymic involvement, autoantibody titer, and immunoglobulin AChR subunit immunodominance-suggesting different underlying etiologies with potential implications for sex-dependent precision …
View article: Navigating a Misty Road: Novel Ways to Study the Impact of Cognition on Driving Performance in Multiple Sclerosis
Navigating a Misty Road: Novel Ways to Study the Impact of Cognition on Driving Performance in Multiple Sclerosis Open
Background/Objectives: The ability to drive is closely linked to participation in daily activities and quality of life in people living with neurological disorders. Cognitive deficits in people with multiple sclerosis (pwMS) are known to h…
View article: Iatrogenic Dementia: Providing Insight into Transmissible Subtype of Alzheimer’s Disease, Creutzfeldt–Jakob Disease and Cerebral Amyloid Angiopathy
Iatrogenic Dementia: Providing Insight into Transmissible Subtype of Alzheimer’s Disease, Creutzfeldt–Jakob Disease and Cerebral Amyloid Angiopathy Open
Within the phenotypic spectrum of Alzheimer’s disease (AD), Creutzfeldt–Jakob disease (CJD) and cerebral amyloid angiopathy (CAA), dementia that is attributed to iatrogenic transmission has increasingly gained scientific attention recently…
View article: Neurological Immune-Related Adverse Events Induced by Immune Checkpoint Inhibitors
Neurological Immune-Related Adverse Events Induced by Immune Checkpoint Inhibitors Open
The use of immune checkpoint inhibitors (ICIs) for the treatment of various advanced and aggressive types of malignancy has significantly increased both survival and long-term remission rates. ICIs block crucial inhibitory pathways of the …
View article: The Time Trajectory of Choroid Plexus Enlargement in Multiple Sclerosis
The Time Trajectory of Choroid Plexus Enlargement in Multiple Sclerosis Open
Choroid plexus (CP) can be seen as a watchtower of the central nervous system (CNS) that actively regulates CNS homeostasis. A growing body of literature suggests that CP alterations are involved in the pathogenesis of multiple sclerosis (…
View article: Apraxia Patterns for the Differentiation between Alzheimer’s Disease and Frontotemporal Dementia Variants
Apraxia Patterns for the Differentiation between Alzheimer’s Disease and Frontotemporal Dementia Variants Open
Background and Objectives: Despite the increasing use of biomarkers, differentiation between Alzheimer’s disease (AD), behavioral variant Frontotemporal Dementia (bvFTD), and Primary Progressive Aphasia (PPA) remains a challenge. Apraxia i…
View article: How Early Is Early Multiple Sclerosis?
How Early Is Early Multiple Sclerosis? Open
The development and further optimization of the diagnostic criteria for multiple sclerosis (MS) emphasize the establishment of an early and accurate diagnosis. So far, numerous studies have revealed the significance of early treatment admi…
View article: Secondary Central Nervous System Demyelinating Disorders in the Elderly: A Narrative Review
Secondary Central Nervous System Demyelinating Disorders in the Elderly: A Narrative Review Open
Secondary demyelinating diseases comprise a wide spectrum group of pathological conditions and may either be attributed to a disorder primarily affecting the neurons or axons, followed by demyelination, or to an underlying condition leadin…
View article: The Experience of a Tertiary Reference Hospital in the Study of Rare Neurological Diseases
The Experience of a Tertiary Reference Hospital in the Study of Rare Neurological Diseases Open
Background and Objectives: Rare diseases (RDs) are life-threatening or chronically impairing conditions that affect about 6% of the world’s population. RDs are often called ‘orphan’ diseases, since people suffering from them attract little…
View article: Long-Term Efficacy Outcomes of Natalizumab vs. Fingolimod in Patients With Highly Active Relapsing-Remitting Multiple Sclerosis: Real-World Data From a Multiple Sclerosis Reference Center
Long-Term Efficacy Outcomes of Natalizumab vs. Fingolimod in Patients With Highly Active Relapsing-Remitting Multiple Sclerosis: Real-World Data From a Multiple Sclerosis Reference Center Open
Background: Natalizumab (NTZ) and fingolimod (FTY) are second-line disease modifying treatments (DMTs) approved for Relapsing – Remitting Multiple Sclerosis (RRMS). Few studies are available on a direct comparison between NTZ and FTY, base…
View article: Estimating Everyday Neuropsychological Functioning in Multiple Sclerosis: Reliability and Validity of the Greek Multiple Sclerosis Neuropsychological Questionnaire
Estimating Everyday Neuropsychological Functioning in Multiple Sclerosis: Reliability and Validity of the Greek Multiple Sclerosis Neuropsychological Questionnaire Open
The Multiple Sclerosis Neuropsychological Questionnaire is a brief screening questionnaire for the assessment of everyday neuropsychological competence of patients with Multiple Sclerosis. The aim of the present study was to examine psycho…
View article: Acute Finger Paralysis: A Case Report of Cortical Ischemic Stroke
Acute Finger Paralysis: A Case Report of Cortical Ischemic Stroke Open
Somatotopic distribution of motor cortex and sensory fibers is theoretically fully understood. We present a case of stroke, mimicking peripheral palsy, with finger paralysis attributed to cortical lesion. The patient's brain MRI may be use…
View article: Neuromyotonia Confined to Faciobulbar Muscles in a Patient with Myasthenia Gravis
Neuromyotonia Confined to Faciobulbar Muscles in a Patient with Myasthenia Gravis Open
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