Dimitrios Tsallos
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View article: Multi-omic and functional screening reveal targetable vulnerabilities in<i>TP53</i>mutated multiple myeloma
Multi-omic and functional screening reveal targetable vulnerabilities in<i>TP53</i>mutated multiple myeloma Open
Despite development of several effective therapies for multiple myeloma (MM), the prognosis of patients with partial deletion of chromosome 17 (del(17p)) and TP53 aberrations remains poor. By applying comprehensive multi-omics profiling an…
View article: Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine Open
Thrombocytopenia, prevalent in the majority of patients with myeloid malignancies, such as myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), is an independent adverse prognostic factor. Azacitidine (AZA), a mainstay therapeut…
View article: A Multiplexed Screening Assay to Evaluate Chemotherapy-Induced Myelosuppression Using Healthy Peripheral Blood and Bone Marrow
A Multiplexed Screening Assay to Evaluate Chemotherapy-Induced Myelosuppression Using Healthy Peripheral Blood and Bone Marrow Open
Myelosuppression is a major side effect of chemotherapy in cancer patients and can result in infections, bleeding complications, and increased risk of morbidity and mortality, as well as limit the drug dose and frequency of administration.…