Dimitrius Raphael
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View article: IFN-γ–producing T <sub>H</sub> 1 cells and dysfunctional regulatory T cells contribute to the pathogenesis of Sjögren’s disease
IFN-γ–producing T <sub>H</sub> 1 cells and dysfunctional regulatory T cells contribute to the pathogenesis of Sjögren’s disease Open
Sjögren’s disease (SjD) is an autoimmune disorder characterized by progressive salivary and lacrimal gland dysfunction, inflammation, and destruction, as well as extraglandular manifestations. SjD is associated with autoreactive B and T ce…
View article: Regulatory T cells and IFN-γ-producing Th1 cells play a critical role in the pathogenesis of Sjögren’s Syndrome
Regulatory T cells and IFN-γ-producing Th1 cells play a critical role in the pathogenesis of Sjögren’s Syndrome Open
Objectives Sjögren’s Disease (SjD) is an autoimmune disorder characterized by progressive dysfunction, inflammation and destruction of salivary and lacrimal glands, and by extraglandular manifestations. Its etiology and pathophysiology rem…
View article: Distinct roles of ORAI1 in T cell–mediated allergic airway inflammation and immunity to influenza A virus infection
Distinct roles of ORAI1 in T cell–mediated allergic airway inflammation and immunity to influenza A virus infection Open
T cell activation and function depend on Ca 2+ signals mediated by store-operated Ca 2+ entry (SOCE) through Ca 2+ release–activated Ca 2+ (CRAC) channels formed by ORAI1 proteins. We here investigated how SOCE controls T cell function in …
View article: STIM1‐mediated calcium influx controls antifungal immunity and the metabolic function of non‐pathogenic Th17 cells
STIM1‐mediated calcium influx controls antifungal immunity and the metabolic function of non‐pathogenic Th17 cells Open
Immunity to fungal infections is mediated by cells of the innate and adaptive immune system including Th17 cells. Ca2+ influx in immune cells is regulated by stromal interaction molecule 1 (STIM1) and its activation of the Ca2+ channel ORA…