Dina Khalaf
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View article: Real-world validation study of the LSC17 score for risk prediction in patients with newly diagnosed acute myeloid leukemia
Real-world validation study of the LSC17 score for risk prediction in patients with newly diagnosed acute myeloid leukemia Open
Acute myeloid leukemia (AML) patients exhibit diverse molecular and cytogenetic changes with heterogeneous outcomes. The functionally-derived LSC17 gene expression score has demonstrated strong prognostic significance in retrospective anal…
View article: Identification Of Bariatric Surgery Complications
Identification Of Bariatric Surgery Complications Open
Background:Obesity is a growing global health issue, often leading to serious comorbidities such as diabetes, hypertension, and sleep apnea. Bariatric surgery has become an increasingly popular treatment for morbid obesity, showing signifi…
View article: Sustainable strategies for preventive maintenance and replacement in photovoltaic power systems: Enhancing reliability, efficiency, and system economy
Sustainable strategies for preventive maintenance and replacement in photovoltaic power systems: Enhancing reliability, efficiency, and system economy Open
This study proposes a preventive maintenance and replacement strategy for photovoltaic (PV) power generation systems, addressing reliability as a key constraint. The research introduces a novel approach incorporating service age regression…
View article: Outcomes of Allogeneic Stem Cell Transplant in Patients with Relapsed/Refractory Hodgkin Lymphoma
Outcomes of Allogeneic Stem Cell Transplant in Patients with Relapsed/Refractory Hodgkin Lymphoma Open
Background: The aim of this study was to evaluate real-world clinical outcomes and transplant-related complications of allogeneic stem cell transplantation (alloSCT) for Hodgkin lymphoma (HL). Methods: This was a single-centre, retrospecti…
View article: Real-World Experience with CPX-351 for Secondary Acute Myeloid Leukemia: Comparison with FLAG-IDA in a Propensity Score Matching Analysis
Real-World Experience with CPX-351 for Secondary Acute Myeloid Leukemia: Comparison with FLAG-IDA in a Propensity Score Matching Analysis Open
CPX-351 is approved for therapy-related acute myeloid leukemia (t-AML), and AML with myelodysplastic-related changes (AML-MRC). This approval was based on improved survival, remission rates, and similar safety compared to 7+3 regimen. In c…
View article: The Transcription Factor IRF8 Regulates the Sensitivity of AML Cells to LSD1 Inhibition and All-Trans Retinoic Acid
The Transcription Factor IRF8 Regulates the Sensitivity of AML Cells to LSD1 Inhibition and All-Trans Retinoic Acid Open
Introduction:Acute myeloid leukemia (AML) is a hematological neoplasm with poor outcomes owing to genetic heterogeneity with many mutations in epigenetic genes. One promising target is histone demethylase LSD1/KDM1A; inhibition of LSD1 (LS…
View article: Healthcare provider's perceptions of bleeding in patients with acute leukaemia undergoing induction chemotherapy: A qualitative study
Healthcare provider's perceptions of bleeding in patients with acute leukaemia undergoing induction chemotherapy: A qualitative study Open
Background Bleeding is a primary outcome for many transfusion‐related trials in acute leukaemia (AL) patients, typically graded using the World Health Organisation (WHO) bleeding scale (clinically significant bleed (CSB) is ≥grade 2). This…
View article: Concurrent <i>BCR‐ABL1</i> and core binding factor beta rearrangement in de novo acute myeloid leukemia: A case report and review of literature
Concurrent <i>BCR‐ABL1</i> and core binding factor beta rearrangement in de novo acute myeloid leukemia: A case report and review of literature Open
A distinct subset of acute myeloid leukemia (AML) is characterized by the presence of the Philadelphia chromosome (Ph+), due to reciprocal translocation t(9;22)(q34;q11.2). This chromosomal rearrangement leads to the fusion of the breakpoi…
View article: Concurrent BCR::-ABL1 and CBFB Rearrangement in De Novo Acute Myeloid Leukemia
Concurrent BCR::-ABL1 and CBFB Rearrangement in De Novo Acute Myeloid Leukemia Open
Introduction Acute myeloid leukemia (AML) is known for its genetic heterogeneity. Several recurrent genetic variants have been characterized including AML-defining chromosomal rearrangements involving the core binding factor (CBF), such as…
View article: Analysis of the Impact of Whole Blood and T-Cell Donor Chimerism after Allogeneic Stem Cell Transplant
Analysis of the Impact of Whole Blood and T-Cell Donor Chimerism after Allogeneic Stem Cell Transplant Open
Background: Allogeneic stem cell transplant (alloSCT) is one of the few currently available therapies to cure acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Positive outcomes are dependent on engraftment of donor cells to…
View article: LSD1 Inhibition Synergizes with Venetoclax in Acute Myeloid Leukemia By Targeting Cellular Metabolism
LSD1 Inhibition Synergizes with Venetoclax in Acute Myeloid Leukemia By Targeting Cellular Metabolism Open
Introduction: Acute myeloid leukemia (AML) is a hematological neoplasm with poor clinical outcomes. The introduction of the BCL2 inhibitor venetoclax in combination with hypomethylating agent has improved response rates in older patients w…
View article: Antiviral therapy defiant mixed viral retinitis post hematopoietic allogeneic stem cell transplant
Antiviral therapy defiant mixed viral retinitis post hematopoietic allogeneic stem cell transplant Open
Cytomegalovirus (CMV) retinitis is an uncommon presentation post allogeneic transplant and can be vision‐threatening. Our case demonstrates the occurrence of polymerase chain reaction (PCR) proven mixed viral retinitis (cytomegalovirus and…
View article: Impact of Frailty on Health Care Resource Utilization and Costs of Care in Myelodysplastic Syndromes
Impact of Frailty on Health Care Resource Utilization and Costs of Care in Myelodysplastic Syndromes Open
PURPOSE: The role of frailty in affecting survival in myelodysplastic syndromes (MDS) is increasingly recognized. Despite this, a paucity of data exists on the association between frailty and other clinically meaningful outcomes including …
View article: The burden of red blood cell transfusions in patients with lower-risk myelodysplastic syndromes and ring sideroblasts: an analysis of the prospective MDS-CAN registry
The burden of red blood cell transfusions in patients with lower-risk myelodysplastic syndromes and ring sideroblasts: an analysis of the prospective MDS-CAN registry Open
Many patients with lower-risk myelodysplastic syndromes (LR MDS) require long-term red blood cell (RBC) transfusions to manage anemia. The consequences of RBC transfusions in LR MDS with ring sideroblasts (LR MDS-RS) are not well known. We…
View article: A natural history of lower-risk myelodysplastic syndromes with ring sideroblasts: an analysis of the MDS-CAN registry
A natural history of lower-risk myelodysplastic syndromes with ring sideroblasts: an analysis of the MDS-CAN registry Open
Patients with lower-risk (LR) myelodysplastic syndromes (MDS) with ring sideroblasts (RS) have better prognosis than those without RS, but how they fare over time is not fully understood. This study's objective was to assess the natural hi…
View article: High transferrin saturation predicts inferior clinical outcomes in patients with myelodysplastic syndromes
High transferrin saturation predicts inferior clinical outcomes in patients with myelodysplastic syndromes Open
Iron overload (IO) reflected by elevated ferritin is associated with increased mortality in myelodysplastic syndromes (MDS), however, ferritin is an imperfect metric. Elevated labile plasma iron correlates with clinical outcomes and transf…
View article: Antiviral Therapy Defiant Polyviral Retinitis Post Hematopoietic Allogeneic Stem Cell Transplant
Antiviral Therapy Defiant Polyviral Retinitis Post Hematopoietic Allogeneic Stem Cell Transplant Open
Cytomegalovirus (CMV) retinitis is an uncommon presentation post allogeneic transplant and can be vision-threatening. This case demonstrates the occurrence of mixed viral retinitis (CMV and varicella zoster virus) post allogeneic stem cell…
View article: P500: A REAL WORLD MULTI CENTRE STUDY OF CPX-351 REVEALS NO DIFFERENCE IN OVERALL SURVIVAL WHEN COMPARED WITH FLAG-IDA AND 3 + 7 IN HIGH RISK AML.
P500: A REAL WORLD MULTI CENTRE STUDY OF CPX-351 REVEALS NO DIFFERENCE IN OVERALL SURVIVAL WHEN COMPARED WITH FLAG-IDA AND 3 + 7 IN HIGH RISK AML. Open
Background: CPX-351 is a liposomal formulation of daunorubicin and cytarabine in a fixed synergistic ratio of 5:1. It has been approved by both the FDA and EMA for use in high-risk AML including therapy related AML (t-AML) and AML with mye…
View article: Cardiovascular events among recipients of hematopoietic stem cell transplantation
Cardiovascular events among recipients of hematopoietic stem cell transplantation Open
Background Allogeneic and autologous hematopoietic stem cell transplantation (HSCT) are potential curative treatments for several hematological malignancies (1). Survival after HSCT has improved over the last decade, but survivors remain a…