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SUN-149 Low level Mosaic LHX1 Gene Deletion Contributes to Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome Open

Dina Kira, Lynn P. Chorich, Zoe Hawkins, Soumia Brakta, Hyung‐Goo Kim , et al. · 2025

Disclosure: D. Kira: None. L.P. Chorich: None. Z.A. Hawkins: None. S. Brakta: None. H. Kim: None. J.A. Phillips: None. L.C. Layman: None. Introduction: MRKH syndrome is a rare severe Mullerian Duct (MD) anomaly where the uterus and upper 2…

7850 Developmental ZNHIT3 expression in mice embryos in Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome related organs Open

Dina Kira, Binnur Eroglu, Zoe Hawkins, Lynn P. Chorich, Soumia Brakta , et al. · 2024

Biology Medicine

Disclosure: D. Kira: None. B. Eroglu, MS, PhD: None. Z. Hawkins: None. L.P. Chorich: None. S. Brakta: None. L.C. Layman: None. Introduction: MRKH is a severe form of the Mullerian duct (MD) anomaly where the upper 2/3 of the vagina and the…

FRI387 Reproductive Capacity Of Znhit3 Knockout Mouse Model Open

Dina Kira, Zoe Hawkins, Lynn P. Chorich, Soumia Brakta, Lin Gan , et al. · 2023

Biology Medicine

Disclosure: D. Kira: None. Z.A. Hawkins: None. L.P. Chorich: None. S. Brakta: None. L. Gan: None. L.C. Layman: None. Introduction: Zinc finger, HIT domain containing 3 (ZNHIT3), also known as thyroid hormone receptor-interacting protein 3 …

Implication of N-Methyl-d-Aspartate Receptor in Homocysteine-Induced Age-Related Macular Degeneration Open

Yara A. Samra, Dina Kira, Pragya Rajpurohit, Riyaz Mohamed, Leah A. Owen , et al. · 2022

Medicine

Age-related macular degeneration (AMD) is a leading cause of vision loss.Elevated homocysteine (Hcy) (Hyperhomocysteinemia) (HHcy) has been reported in AMD.We previously reported that HHcy induces AMD-like features.This study suggests that…

Implication of N-Methyl-d-Aspartate Receptor in Homocysteine-Induced Age-Related Macular Degeneration Open

Yara A. Samra, Dina Kira, Pragya Rajpurohit, Riyaz Mohamed, Leah A. Owen , et al. · 2021

Medicine Chemistry

Age-related macular degeneration (AMD) is a leading cause of vision loss. Elevated homocysteine (Hcy) (Hyperhomocysteinemia) (HHcy) has been reported in AMD. We previously reported that HHcy induces AMD-like features. This study suggests t…

Implication of N-methyl-D-aspartate receptor In Homocysteine Induced Age related Macular Degeneration Open

Yara A. Samra, Dina Kira, Pragya Rajpurohit, Riyaz Mohamed, Leah A. Owen , et al. · 2021

Medicine Biology

Background: Age related macular degeneration (AMD) is a leading cause of vision loss in old people. Elevated homocysteine (Hcy), known as Hyperhomocysteinemia (HHcy) was reported in association with AMD. We previously reported that HHcy in…

Homocysteine Induces Inflammation in Retina and Brain Open

Nehal M. Elsherbiny, Isha Sharma, Dina Kira, Suhib Alhusban, Yara A. Samra , et al. · 2020

Biology Medicine

Homocysteine (Hcy) is an amino acid that requires vitamins B12 and folic acid for its metabolism. Vitamins B12 and folic acid deficiencies lead to hyperhomocysteinemia (HHcy, elevated Hcy), which is linked to the development of diabetic re…

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