Dinesh Kumar Sinha
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View article: Role of microRNA-486-5p as Biomarker Response in Cell Line K562 of Chronic Myeloid Leukemia
Role of microRNA-486-5p as Biomarker Response in Cell Line K562 of Chronic Myeloid Leukemia Open
Numerous reports demonstrate the role of miRNA in acting as oncogenes or tumor suppressors in various cancers. We have reported an alteration in the expression of miR-486-5p in the CML cell line. The upregulation of miR-486-5p expression i…
View article: Analytical study of radiotherapy techniques in left-sided breast irradiation using integrated scoring and risk assessment method
Analytical study of radiotherapy techniques in left-sided breast irradiation using integrated scoring and risk assessment method Open
Background: Optimal radiotherapy technique selection for left-sided breast cancer remains challenging. This study compared volumetric-modulated arc therapy (VMAT), VMAT+IMRT (VMAT+IMRT) and IMRT+VMAT (IMRT+VMAT) using an innovative integra…
View article: Comparative dosimetric evaluation of hybrid volumetric modulated arc therapy techniques for oesophageal cancer: a treatment planning study
Comparative dosimetric evaluation of hybrid volumetric modulated arc therapy techniques for oesophageal cancer: a treatment planning study Open
Objective: To find the optimal dose weighting for a combination of three-dimensional conformal radiotherapy (3DCRT) and hybrid volumetric modulated arc therapy (hVMAT) plans for thoracic oesophageal cancer radiation therapy. Methods and Ma…
View article: Trends and Patterns of Top Ten Common Cancers in Eastern India from 2014 to 2021: A Retrospective Hospital-based Cancer Registry Data Update
Trends and Patterns of Top Ten Common Cancers in Eastern India from 2014 to 2021: A Retrospective Hospital-based Cancer Registry Data Update Open
Background: India is a vast and diverse country with existing variations in the frequency and distribution of cancers across its various parts. In regions lacking population-based cancer registries (PBCRs) in a vast country like India, hos…
View article: Inclusion of patients lost to follow-up in “Kaplan-Meier” cumulative survival curves
Inclusion of patients lost to follow-up in “Kaplan-Meier” cumulative survival curves Open
View article: Diversity of small round cell sarcoma in soft tissues around bone among Indian patients
Diversity of small round cell sarcoma in soft tissues around bone among Indian patients Open
Round cell tumors are a group of malignant tumors which shows overlapping microscopic features of small round monotonous cells with hyper-chromatic nucleus. It mostly occurs in children, adolescent, and young adults. The ancillary techniqu…
View article: Spectrum of chemo-radiotherapy induced fungal infection in head and neck cancer patients at tertiary care centre of Eastern India
Spectrum of chemo-radiotherapy induced fungal infection in head and neck cancer patients at tertiary care centre of Eastern India Open
Background: Cancer management is a dynamically developing field. Chemotherapy and radiation affect the level and duration of immunosuppression in the already immunocompromised cancer hosts, leaving them vulnerable to various opportunistic …
View article: Epidemiological trends of colorectal cancer cases in young population of Eastern India: A retrospective observational study
Epidemiological trends of colorectal cancer cases in young population of Eastern India: A retrospective observational study Open
Background: Colorectal cancer (CRC) is a disease of the older population in developed countries where the incidence among the young is rising despite the decline in the overall incidence. Contrary to this, in India, which is a low-incidenc…
View article: Assessment of tumor markers CA 19-9, CEA, CA 125, and CA 242 for the early diagnosis and prognosis prediction of gallbladder cancer
Assessment of tumor markers CA 19-9, CEA, CA 125, and CA 242 for the early diagnosis and prognosis prediction of gallbladder cancer Open
Serum levels of tumor markers including CA 19-9, CA 125, CEA, and CA 242 were significantly associated with GBC. However, no significant association was observed between the presence of elevated levels of any tumor marker with respect to s…
View article: Genomic Pattern of GSTM1 and T1 Gene Null polymorphism of Head and Neck Cancer Patients in Eastern India
Genomic Pattern of GSTM1 and T1 Gene Null polymorphism of Head and Neck Cancer Patients in Eastern India Open
The result indicated that there was strong association of GSTM0 and GSTT0 null polymorphism in those patients. The combined genotypes i.e., GSTM0T1 and GSTM0T0 null polymorphism also showed significant association in HNC patients.
View article: Efficacy and tolerability of <scp>once‐weekly</scp> selinexor, bortezomib, and dexamethasone in comparison with standard <scp>twice‐weekly</scp> bortezomib and dexamethasone in previously treated multiple myeloma with renal impairment: Subgroup analysis from the <scp>BOSTON</scp> study
Efficacy and tolerability of <span>once‐weekly</span> selinexor, bortezomib, and dexamethasone in comparison with standard <span>twice‐weekly</span> bortezomib and dexamethasone in previously treated multiple myeloma with renal impairment: Subgroup analysis from the <span>BOSTON</span> study Open
Patients with hematological malignancies, particularly multiple myeloma (MM), typically have a high prevalence of renal impairment (RI). When combined with the nephrotoxic risk of anticancer drugs, especially with an older patient populati…
View article: Peripheral neuropathy symptoms, pain, and functioning in previously treated multiple myeloma patients treated with selinexor, bortezomib, and dexamethasone
Peripheral neuropathy symptoms, pain, and functioning in previously treated multiple myeloma patients treated with selinexor, bortezomib, and dexamethasone Open
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View article: Selinexor, bortezomib, and dexamethasone versus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes by cytogenetic risk
Selinexor, bortezomib, and dexamethasone versus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes by cytogenetic risk Open
In the phase 3 BOSTON study, patients with multiple myeloma (MM) after 1–3 prior regimens were randomized to once‐weekly selinexor (an oral inhibitor of exportin 1 [XPO1]) plus bortezomib‐dexamethasone (XVd) or twice‐weekly bortezomib‐dexa…
View article: Effect of prior treatments on selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma
Effect of prior treatments on selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma Open
View article: Effect of age and frailty on the efficacy and tolerability of once‐weekly selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma
Effect of age and frailty on the efficacy and tolerability of once‐weekly selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma Open
Elderly and frail patients with multiple myeloma (MM) are more vulnerable to the toxicity of combination therapies, often resulting in treatment modifications and suboptimal outcomes. The phase 3 BOSTON study showed that once‐weekly seline…
View article: Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma (BOSTON): a randomised, open-label, phase 3 trial
Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma (BOSTON): a randomised, open-label, phase 3 trial Open
View article: Brain Tumor Management Amidst COVID-19 Pandemic
Brain Tumor Management Amidst COVID-19 Pandemic Open
In May, Brain Tumor Awareness Month, we are facing challenges pertaining to brain cancer and coronavirus (COVID-19) pandemic. With no effective treatment and no vaccine currently available, the most effective means of slowing the dissemina…
View article: Hepatitis B in hepatocellular carcinoma patients and its correlation with alpha-fetoprotein and liver enzymes
Hepatitis B in hepatocellular carcinoma patients and its correlation with alpha-fetoprotein and liver enzymes Open
Background: Hepatocellular carcinoma (HCC) in India ranges from 0.7 to 7.5 for men and 0.2 to 2.2 for women, per 100,000 population per year. The major risk factors for the development of HCC are infection with hepatitis B virus (HBV), hep…
View article: Eosinophilic Granuloma of The Skull in An Adolescent Male
Eosinophilic Granuloma of The Skull in An Adolescent Male Open
Eosinophilic granuloma is a variety of histiocytosis-X with unknown etiology. Eosinophilic granuloma is very rare benign bone tumor which presents in more than 90 % in children under the age often years. There is predominance for males. It…