Dinesh S. Rao
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View article: A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity
A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity Open
The RNA-binding protein IGF2BP3 is an oncofetal protein overexpressed in B-acute lymphoblastic leukemia and is critical for leukemogenesis in experimental models. With cancerspecific expression, functional dispensability for normal develop…
View article: IGF2BP3 remodels the microRNA targeting landscape in MLL-AF4 leukemia
IGF2BP3 remodels the microRNA targeting landscape in MLL-AF4 leukemia Open
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3/I3) is a multi-domain RNA-binding protein required for MLL-AF4-driven leukemogenesis, but its mechanism of action remains enigmatic. We hypothesized from our previous work that I…
View article: IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation
IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation Open
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an oncofetal RNA-binding protein and a non-canonical reader of N6-methyladenosine (m6A) mRNA modifications, is known to be critical for leukemogenesis. To understand…
View article: Distinct roles for NF-κB in hematopoietic stem cells and the bone marrow milieu in promoting hematopoietic aging
Distinct roles for NF-κB in hematopoietic stem cells and the bone marrow milieu in promoting hematopoietic aging Open
Hematopoietic aging is characterized by chronic inflammation associated with myeloid bias, hematopoietic stem cell (HSC) accumulation, and functional HSC impairment. Yet it remains unclear how inflammation promotes aging phenotypes. Nuclea…
View article: A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity
A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity Open
The RNA-binding protein IGF2BP3 is an oncofetal protein overexpressed in B-acute lymphoblastic leukemia and is critical for leukemogenesis in experimental models. With cancer-specific expression, functional dispensability for normal develo…
View article: A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy
A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy Open
The rising incidence of advanced-stage colorectal cancer (CRC) and poor survival outcomes necessitate new and effective therapies. Immune checkpoint inhibitors (ICIs), specifically anti-PD-1 therapy, show promise, yet clinical determinants…
View article: Distinct causes of three phenotypic hallmarks of hematopoietic aging
Distinct causes of three phenotypic hallmarks of hematopoietic aging Open
Hematopoietic aging is characterized by chronic inflammation associated with myeloid bias, HSC accumulation, and functional HSC impairment. Yet it remains unclear how inflammation promotes these aging phenotypes. NFkappaB both responds to …
View article: Population dynamics modeling reveals that myeloid bias involves both HSC differentiation and progenitor proliferation biases
Population dynamics modeling reveals that myeloid bias involves both HSC differentiation and progenitor proliferation biases Open
Aging and chronic inflammation are associated with overabundant myeloid-primed multipotent progenitors (MPPs) among hematopoietic stem and progenitor cells (HSPCs). Although hematopoietic stem cell (HSC) differentiation bias has been consi…
View article: Metabolic regulation of RNA methylation by the m6A-reader IGF2BP3
Metabolic regulation of RNA methylation by the m6A-reader IGF2BP3 Open
The interplay of RNA modifications - deposited by "writers", removed by "erasers" and identified by RNA binding proteins known as "readers" - forms the basis of the epitranscriptomic gene regulation hypothesis. Recent studies have identifi…
View article: Envelope protein-specific B cell receptors direct lentiviral vector tropism in vivo
Envelope protein-specific B cell receptors direct lentiviral vector tropism in vivo Open
View article: Small molecule inhibition of RNA binding proteins in haematologic cancer
Small molecule inhibition of RNA binding proteins in haematologic cancer Open
In recent years, advances in biomedicine have revealed an important role for post-transcriptional mechanisms of gene expression regulation in pathologic conditions. In cancer in general and leukaemia specifically, RNA binding proteins have…
View article: Targeting IGF2BP3 enhances antileukemic effects of menin-MLL inhibition in MLL-AF4 leukemia
Targeting IGF2BP3 enhances antileukemic effects of menin-MLL inhibition in MLL-AF4 leukemia Open
RNA-binding proteins (RBPs) are emerging as a novel class of therapeutic targets in cancer, including in leukemia, given their important role in posttranscriptional gene regulation, and have the unexplored potential to be combined with exi…
View article: IGF2BP3 as a Prognostic Biomarker in Well-Differentiated/Dedifferentiated Liposarcoma
IGF2BP3 as a Prognostic Biomarker in Well-Differentiated/Dedifferentiated Liposarcoma Open
Background: Although IGF2BP3 has been implicated in tumorigenesis and poor outcomes in multiple cancers, its role in soft-tissue sarcoma (STS) remains unknown. Preliminary data have suggested an association with IGF2BP3 expression among pa…
View article: RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia
RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia Open
View article: miRNA-1 promotes acute myeloid leukemia cell pathogenesis through metabolic regulation
miRNA-1 promotes acute myeloid leukemia cell pathogenesis through metabolic regulation Open
Graphical Abstract We blocked pyruvate entry into mitochondria and decreased Oxidative Phosphorylation (OXPHOS) in human AML cell lines MV4-11 and MOLM-14 by using gene editing tools. This metabolic shift led to increased expression of miR…
View article: Distinct oncogenic phenotypes in hematopoietic specific deletions of Trp53
Distinct oncogenic phenotypes in hematopoietic specific deletions of Trp53 Open
Loss of function in the tumor suppressor gene TP53 is the most common alteration seen in human cancer. In mice, P53 deletion in all cells leads predominantly to the development of T-cell lymphomas, followed by B-cell lymphomas, sarcomas an…
View article: Acute Myeloid Leukemia, Version 3.2023, NCCN Clinical Practice Guidelines in Oncology
Acute Myeloid Leukemia, Version 3.2023, NCCN Clinical Practice Guidelines in Oncology Open
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the clonal expansion of myeloid blasts in the peripheral blood, bone marrow, and/or other tissues. It is the most common form of acute leukemia among a…
View article: Supplemental Information from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia
Supplemental Information from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia Open
Supplemental Information. Additional Methods and Supplemental Figure Legends
View article: Data from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia
Data from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia Open
Long noncoding RNAs (lncRNA) have been found to play a role in gene regulation with dysregulated expression in various cancers. The precise role that lncRNA expression plays in the pathogenesis of B-acute lymphoblastic leukemia (B-ALL) is …
View article: Supplemental Figures 1-7 from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia
Supplemental Figures 1-7 from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia Open
Supplemental Figures 1-7. Supplemental Figure 1: Schematic depiction of the pipeline to determine pathophysiologically important lncRNAs. Supplemental Figure 2: LncRNA expression can predict the cytogenetic subtype of B-ALL. Supplemental F…
View article: Data from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia
Data from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia Open
Long noncoding RNAs (lncRNA) have been found to play a role in gene regulation with dysregulated expression in various cancers. The precise role that lncRNA expression plays in the pathogenesis of B-acute lymphoblastic leukemia (B-ALL) is …
View article: Supplemental Figures 1-7 from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia
Supplemental Figures 1-7 from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia Open
Supplemental Figures 1-7. Supplemental Figure 1: Schematic depiction of the pipeline to determine pathophysiologically important lncRNAs. Supplemental Figure 2: LncRNA expression can predict the cytogenetic subtype of B-ALL. Supplemental F…
View article: Supplemental Tables 1 - 4 from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia
Supplemental Tables 1 - 4 from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia Open
Supplemental Tables 1 - 4. Supplemental Table 1: Patient characteristics for use in this study. Supplemental Table 2: Correlational bivariate analyses between ordinal variable clinicopathologic characteristics. Supplemental Table 3: Result…
View article: Supplemental Information from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia
Supplemental Information from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia Open
Supplemental Information. Additional Methods and Supplemental Figure Legends
View article: Supplemental Tables 1 - 4 from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia
Supplemental Tables 1 - 4 from LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia Open
Supplemental Tables 1 - 4. Supplemental Table 1: Patient characteristics for use in this study. Supplemental Table 2: Correlational bivariate analyses between ordinal variable clinicopathologic characteristics. Supplemental Table 3: Result…
View article: RNA binding proteins in MLL-rearranged leukemia
RNA binding proteins in MLL-rearranged leukemia Open
View article: Regulation of T-independent B-cell responses by microRNA-146a
Regulation of T-independent B-cell responses by microRNA-146a Open
The microRNA, miR-146a, is a negative feedback regulator of the central immune transcription factor, nuclear factor kappa B (NFkB). MiR-146a plays important roles in the immune system, and miR-146a deficient mice show a complex phenotype w…
View article: Cooperativity of IGF2BP1 and ETV6-RUNX1 in the pathogenesis of ETV6- RUNX1 positive B-Cell Acute Lymphoblastic Leukemia
Cooperativity of IGF2BP1 and ETV6-RUNX1 in the pathogenesis of ETV6- RUNX1 positive B-Cell Acute Lymphoblastic Leukemia Open
Background ETV6-RUNX1 is the most prevalent translocation in pediatric B-ALL (B-cell Acute Lymphoblastic Leukemia). However, the exact pathogenesis of this translocation leading to leukemogenesis remains unclear. Insulin like Growth Factor…
View article: Concordance of Peripheral Blood and Bone Marrow Next-Generation Sequencing in Hematologic Neoplasms
Concordance of Peripheral Blood and Bone Marrow Next-Generation Sequencing in Hematologic Neoplasms Open
Objective. Mutational analysis by next-generation sequencing (NGS) obtained by peripheral blood NGS has been of clinical interest to use as a minimally invasive screening tool. Our study evaluates the correlation between NGS results on per…
View article: The long non-coding RNA CDK6-AS1 overexpression impacts on acute myeloid leukemia differentiation and mitochondrial dynamics
The long non-coding RNA CDK6-AS1 overexpression impacts on acute myeloid leukemia differentiation and mitochondrial dynamics Open