Dinesh Subedi
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View article: Isolation, engineering and ecology of temperate phages from the human gut
Isolation, engineering and ecology of temperate phages from the human gut Open
View article: Publisher Correction: Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections
Publisher Correction: Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections Open
View article: Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections
Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections Open
The Alfred Hospital in Melbourne, Australia, has reported an ongoing outbreak of infections caused by multidrug-resistant Enterobacter cloacae complex (ECC). Phage therapy is a promising strategy to treat antimicrobial-resistant infections…
View article: Mechanistic insights and clinical implications of cross-reactive anti-prophage antibodies and bacterial heteroresistance on phage therapeutic failure
Mechanistic insights and clinical implications of cross-reactive anti-prophage antibodies and bacterial heteroresistance on phage therapeutic failure Open
Phage therapy is an exciting strategy against antimicrobial-resistant bacterial infections, but critical knowledge gaps regarding its clinical application persist. Studying a patient with a life-threatening, chronic bacterial infection who…
View article: Ultraviolet radiation vs air filtration to mitigate virus laden aerosol in an occupied clinical room
Ultraviolet radiation vs air filtration to mitigate virus laden aerosol in an occupied clinical room Open
Mitigation measures against infectious aerosols are desperately needed. We aimed to: 1) compare germicidal ultraviolet radiation (GUV) at 254 nm (254-GUVUpper-Room) and 222 nm (222-GUVWhole-Room) with portable high ef…
View article: Rational Design of Frontline Institutional Phage Cocktail for the Treatment of Nosocomial<i>Enterobacter cloacae</i>Complex Infections
Rational Design of Frontline Institutional Phage Cocktail for the Treatment of Nosocomial<i>Enterobacter cloacae</i>Complex Infections Open
Phage therapy is a promising strategy to treat antimicrobial-resistant infections. Currently, phage therapy applications span personalised treatments that are tailored for a given patient’s infection, through to the use of pre-established …
View article: Editorial: Bacteriophages to treat infections with multidrug resistant pathogens
Editorial: Bacteriophages to treat infections with multidrug resistant pathogens Open
EDITORIAL article Front. Med., 05 January 2024Sec. Infectious Diseases: Pathogenesis and Therapy Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1348463
View article: Ultraviolet Radiation vs Air Filtration to Mitigate Virus Laden Aerosol in an Occupied Clinical Room
Ultraviolet Radiation vs Air Filtration to Mitigate Virus Laden Aerosol in an Occupied Clinical Room Open
View article: Temperate gut phages are prevalent, diverse, and predominantly inactive
Temperate gut phages are prevalent, diverse, and predominantly inactive Open
Large-scale metagenomic and data mining efforts have uncovered an expansive diversity of bacteriophages (phages) within the human gut 1–3 . These insights include broader phage populational dynamics such as temporal stability 4 , interindi…
View article: Quantifying the reduction of airborne infectious viral load using a ventilated patient hood
Quantifying the reduction of airborne infectious viral load using a ventilated patient hood Open
View article: Assessment of genotypes, endosymbionts and clinical characteristics of Acanthamoeba recovered from ocular infection
Assessment of genotypes, endosymbionts and clinical characteristics of Acanthamoeba recovered from ocular infection Open
View article: Hcp Proteins of the Type VI Secretion System Promote Avian Pathogenic E. coli DE205B (O2:K1) to Induce Meningitis in Rats
Hcp Proteins of the Type VI Secretion System Promote Avian Pathogenic E. coli DE205B (O2:K1) to Induce Meningitis in Rats Open
Avian pathogenic Escherichia coli (APEC) is an important extra-intestinal pathogenic E. coli (ExPEC), which often causes systemic infection in poultry and causes great economic loss to the breeding industry. In addition, as a major source …
View article: Efficacy of a patient isolation hood in reducing exposure to airborne infectious virus in a simulated healthcare setting
Efficacy of a patient isolation hood in reducing exposure to airborne infectious virus in a simulated healthcare setting Open
Background Healthcare workers treating patients with SARS-CoV-2 are at risk of infection from patient-emitted virus-laden aerosols. We quantified the reduction of airborne infectious virus in a simulated hospital room when a ventilated pat…
View article: Phage Cocktail Targeting STEC O157:H7 Has Comparable Efficacy and Superior Recovery Compared with Enrofloxacin in an Enteric Murine Model
Phage Cocktail Targeting STEC O157:H7 Has Comparable Efficacy and Superior Recovery Compared with Enrofloxacin in an Enteric Murine Model Open
With the increasing severity of antibiotic resistance and other adverse consequences, animal experiments and clinical trials investigating the use of phages for the control and prevention of enteric bacterial infections are growing. Howeve…
View article: Phage-antibiotic combination is a superior treatment against Acinetobacter baumannii in a preclinical study
Phage-antibiotic combination is a superior treatment against Acinetobacter baumannii in a preclinical study Open
View article: Fit-Tested N95 Masks Combined With Portable High-Efficiency Particulate Air Filtration Can Protect Against High Aerosolized Viral Loads Over Prolonged Periods at Close Range
Fit-Tested N95 Masks Combined With Portable High-Efficiency Particulate Air Filtration Can Protect Against High Aerosolized Viral Loads Over Prolonged Periods at Close Range Open
Background Healthcare workers (HCWs) are at risk from aerosol transmission of severe acute respiratory syndrome coronavirus 2. The aims of this study were to (1) quantify the protection provided by masks (surgical, fit-testFAILED N95, fit-…
View article: Point of emission air filtration enhances protection of healthcare workers against skin contamination with virus aerosol
Point of emission air filtration enhances protection of healthcare workers against skin contamination with virus aerosol Open
See related Editorial
View article: Virus aerosol propagation by continuous positive airways pressure (CPAP) is proportional to mask leak
Virus aerosol propagation by continuous positive airways pressure (CPAP) is proportional to mask leak Open
View article: Personal protective equipment does not sufficiently protect against virus aerosol unless combined with advanced air purification or ventilation techniques
Personal protective equipment does not sufficiently protect against virus aerosol unless combined with advanced air purification or ventilation techniques Open
Background Healthcare workers (HCWs) are at risk from nosocomial transmission of SARS-CoV-2 from virus laden aerosols. This study aimed to: 1) quantify the degree of protection from virus aerosol provided by different types of mask (surgic…
View article: Point of emission air filtration enhances protection of health care workers against skin contamination with virus aerosol
Point of emission air filtration enhances protection of health care workers against skin contamination with virus aerosol Open
Rationale: We recently demonstrated that a patient hood with a high efficiency particulate air filter eliminates virus aerosol contamination when very large quantities of bacteriophage virus are aerosolised into a clinical room. While this…
View article: The Autofluorescence Patterns of Acanthamoeba castellanii, Pseudomonas aeruginosa and Staphylococcus aureus: Effects of Antibiotics and Tetracaine
The Autofluorescence Patterns of Acanthamoeba castellanii, Pseudomonas aeruginosa and Staphylococcus aureus: Effects of Antibiotics and Tetracaine Open
Acanthamoeba Keratitis (AK) can lead to substantial vision loss and morbidity among contact lens wearers. Misdiagnosis or delayed diagnosis is a major factor contributing to poor outcomes of AK. This study aimed to assess the effect of two…
View article: Innate and Adaptive Gene Single Nucleotide Polymorphisms Associated With Susceptibility of Severe Inflammatory Complications in <i>Acanthamoeba</i> Keratitis
Innate and Adaptive Gene Single Nucleotide Polymorphisms Associated With Susceptibility of Severe Inflammatory Complications in <i>Acanthamoeba</i> Keratitis Open
The current study identifies biologically relevant genetic variants in patients with AK with SICs; IL-8 is associated with a strong neutrophil response in the cornea in AK, TLR-4 is important in early AK disease, and Th-17 genes are associ…
View article: Engineering laminated paper for SARS-CoV-2 medical gowns
Engineering laminated paper for SARS-CoV-2 medical gowns Open
View article: A Systematic Review of Intracellular Microorganisms within Acanthamoeba to Understand Potential Impact for Infection
A Systematic Review of Intracellular Microorganisms within Acanthamoeba to Understand Potential Impact for Infection Open
Acanthamoeba, an opportunistic pathogen is known to cause an infection of the cornea, central nervous system, and skin. Acanthamoeba feeds different microorganisms, including potentially pathogenic prokaryotes; some of microbes have develo…
View article: Temporal Stability and Genetic Diversity of 48-Year-Old T-Series Phages
Temporal Stability and Genetic Diversity of 48-Year-Old T-Series Phages Open
T-series bacteriophages have been used throughout the world for various molecular biology researches, which were critical for establishing the fundamentals of molecular biology, from the structure of DNA to advanced gene-editing tools. The…
View article: Investigating Domestic Shower Settings as a Risk Factor for Acanthamoeba Keratitis
Investigating Domestic Shower Settings as a Risk Factor for Acanthamoeba Keratitis Open
Acanthamoeba keratitis (AK) is a sight-threatening infection of the cornea, which is caused by soil and the waterborne protist Acanthamoeba spp. AK most commonly occurs during contact lens (CL) wear. Risk factors for AK have been linked to…
View article: Viable virus aerosol propagation by positive airway pressure circuit leak and mitigation with a ventilated patient hood
Viable virus aerosol propagation by positive airway pressure circuit leak and mitigation with a ventilated patient hood Open
Introduction Nosocomial transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major feature of the COVID-19 pandemic. Evidence suggests patients can auto-emit aerosols containing viable viruses; these aero…
View article: Temporal stability and genetic diversity of 48-year old T-series phages
Temporal stability and genetic diversity of 48-year old T-series phages Open
T-series phages have been model organisms for molecular biology since the 1940s. Given that these phages have been stocked, distributed, and propagated for decades across the globe, there exists the potential for genetic drift to accumulat…
View article: Viable virus aerosol propagation by PAP circuit leak and mitigation with a ventilated patient hood – a model for improving health care worker safety in the COVID-19 pandemic
Viable virus aerosol propagation by PAP circuit leak and mitigation with a ventilated patient hood – a model for improving health care worker safety in the COVID-19 pandemic Open
Background Nosocomial transmission of SARS-CoV-2 has been a major cause of morbidity and mortality in the COVID-19 pandemic. Emerging evidence suggests patients auto-emit aerosols containing viable respiratory viruses. These aerosols could…
View article: The effect on the autofluorescence signal of corneal microorganisms with common topical drugs
The effect on the autofluorescence signal of corneal microorganisms with common topical drugs Open