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View article: Deep learning-based brain age predicts stroke recurrence in acute ischemic cerebrovascular disease
Deep learning-based brain age predicts stroke recurrence in acute ischemic cerebrovascular disease Open
Acute ischemic cerebrovascular disease (AICVD) exhibits high recurrence rates, necessitating novel biomarkers for refined risk stratification. While MRI-derived brain age correlates with stroke incidence, its prognostic utility for recurre…
View article: The variable splicing factor RBM17 regulates MDS cell proliferation through H3K27la
The variable splicing factor RBM17 regulates MDS cell proliferation through H3K27la Open
Myelodysplastic syndrome is characterized by reduced production of all three lineages of blood cells, primarily affecting elderly individuals. Hematopoietic stem cell transplantation is the only curative treatment for MDS, but only a minor…
View article: Rationale and design of Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined with Endovascular Treatment in ACute Ischaemic StrokE (RETRACE II): a randomised double-blind controlled multicentre phase II pilot study
Rationale and design of Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined with Endovascular Treatment in ACute Ischaemic StrokE (RETRACE II): a randomised double-blind controlled multicentre phase II pilot study Open
Background While endovascular therapy (EVT) remains the primary treatment for acute ischaemic stroke (AIS) management, persistent functional deficits in patients with successful recanalisation underscore the necessity for complementary neu…
View article: Mechanism by which hydrogen-rich water mitigates exercise-induced fatigue: activation of the immunoresponsive gene 1-itaconate/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway
Mechanism by which hydrogen-rich water mitigates exercise-induced fatigue: activation of the immunoresponsive gene 1-itaconate/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway Open
JOURNAL/mgres/04.03/01612956-202603000-00005/figure1/v/2025-08-04T105942Z/r/image-tiff Exercise-induced fatigue limits athletic performance. Molecular hydrogen is an effective treatment for relieving fatigue, but the exact mechanism is not…
View article: P-311 Previous conservative treatment of atypical hyperplasia decreased cumulative live birth rate after IVF/ICSI: a propensity score matched retrospective cohort study
P-311 Previous conservative treatment of atypical hyperplasia decreased cumulative live birth rate after IVF/ICSI: a propensity score matched retrospective cohort study Open
Study question Do women have worse pregnancy and neonatal outcomes of a complete IVF/ICSI cycle after conservative treatment of atypical hyperplasia (AH)? Summary answer Women with AH suffered a significantly lower cumulative live birth ra…
View article: A randomized controlled study on the safety and efficacy of microhyperbaric oxygen therapy in patients with severe COVID-19 infection
A randomized controlled study on the safety and efficacy of microhyperbaric oxygen therapy in patients with severe COVID-19 infection Open
Introduction: COVID-19 pandemic remains an acute global emergency. The situation was especially worrying in mainland China. However, paxlovid shortage led to the underuse of recommended antivirus treatment. Hyperbaric oxygen therapy (HBOT)…
View article: Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial
Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial Open
Objective To test the hypothesis that a freeze-all strategy would increase the chance of live birth compared with fresh embryo transfer in women with low prognosis for in vitro fertilisation (IVF) treatment. Design Pragmatic, multicentre, …
View article: Development and Verification of Diagnosis Model for Papillary Thyroid Cancer Based on Pyroptosis-Related Genes: A Bioinformatic and in vitro Investigation
Development and Verification of Diagnosis Model for Papillary Thyroid Cancer Based on Pyroptosis-Related Genes: A Bioinformatic and in vitro Investigation Open
Our results suggest that pyroptosis-related genes can be used for PTC diagnosis, and NOD1 could be a promising therapeutic target.
View article: Association between PPAR<b>γ</b> polymorphisms and neurological functional disability of ischemic stroke
Association between PPAR<b>γ</b> polymorphisms and neurological functional disability of ischemic stroke Open
Peroxisome proliferator-activated receptor-γ ( PPARγ) plays a protective role against brain injury after stroke in mice. However, the relationship between PPARγ gene polymorphisms and the functional outcome of acute ischemic stroke (AIS) r…
View article: Prosapogenin A induces GSDME-dependent pyroptosis of anaplastic thyroid cancer through vacuolar ATPase activation-mediated lysosomal over-acidification
Prosapogenin A induces GSDME-dependent pyroptosis of anaplastic thyroid cancer through vacuolar ATPase activation-mediated lysosomal over-acidification Open
Anaplastic thyroid cancer (ATC) is among the most aggressive and metastatic malignancies, often resulting in fatal outcomes due to the lack of effective treatments. Prosapogenin A (PA), a bioactive compound prevalent in traditional Chinese…
View article: Data‐Driven Analysis Reveals Cortical Infarction Patterns Correlated With Inflammation and Prognosis: A Retrospective, Multicenter Cohort Study
Data‐Driven Analysis Reveals Cortical Infarction Patterns Correlated With Inflammation and Prognosis: A Retrospective, Multicenter Cohort Study Open
Background We aim to identify the distinct lesion patterns and regions associated with functional outcome and inflammation in patients with acute ischemic stroke, and investigate whether the association between lesion patterns and function…
View article: Chlorpyrifos degradation and its impacts on phosphorus bioavailability in microplastic-contaminated soil
Chlorpyrifos degradation and its impacts on phosphorus bioavailability in microplastic-contaminated soil Open
Pesticide residues and microplastics (MPs) in agricultural soils are two major concerns for soil health and food safety. The degradation of chlorpyrifos (CPF), an organophosphorus pesticide, releases phosphates. This process may be affecte…
View article: Clinical characteristics and prognostic analysis of gene mutations in Myelodysplastic Syndrome
Clinical characteristics and prognostic analysis of gene mutations in Myelodysplastic Syndrome Open
Myelodysplastic syndromes (MDS) are heterogeneous clonal diseases characterized by cytopenia caused by ineffective hematopoiesis and high risk of transformation into acute myeloid leukemia (AML). Genetic mutations are an essential pathogen…
View article: Life Satisfaction and Its Relationship With Personality Traits Among Medical College Students in China
Life Satisfaction and Its Relationship With Personality Traits Among Medical College Students in China Open
Background: Life satisfaction is a comprehensive psychological index to measure a person's life quality. Previous studies have found that population sociological factors, physiological factors, psychological factors, and social factors all…
View article: Imaging of Angiogenesis in White Matter Hyperintensities
Imaging of Angiogenesis in White Matter Hyperintensities Open
Background White matter hyperintensities (WMHs) are areas of increased signal intensity on T2‐weighted magnetic resonance imaging (MRI). WMH penumbra may be a potential target for early intervention in WMHs. We explored the relationship be…
View article: Rationale and design of the GOLDEN BRIDGE II: a cluster-randomised multifaceted intervention trial of an artificial intelligence-based cerebrovascular disease clinical decision support system to improve stroke outcomes and care quality in China
Rationale and design of the GOLDEN BRIDGE II: a cluster-randomised multifaceted intervention trial of an artificial intelligence-based cerebrovascular disease clinical decision support system to improve stroke outcomes and care quality in China Open
Background Given the swift advancements in artificial intelligence (AI), the utilisation of AI-based clinical decision support systems (AI-CDSSs) has become increasingly prevalent in the medical domain, particularly in the management of ce…
View article: Issue Information
Issue Information Open
Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries.
View article: Safety and efficacy of Low-pressure hyperbaric oxygenation in severe COVID-19 patients: a study protocol of an open-label randomised controlled trial
Safety and efficacy of Low-pressure hyperbaric oxygenation in severe COVID-19 patients: a study protocol of an open-label randomised controlled trial Open
Introduction: COVID-19 pandemic remains an acute global emergency. The situation was especially worrying in mainland China. However, paxlovid shortage led to the underuse of recommended antivirus treatment. Hyperbaric oxygen (HBO) therapy …
View article: Machine learning to analyze the factors influencing myopia in students of different school periods
Machine learning to analyze the factors influencing myopia in students of different school periods Open
Purpose We aim to develop myopia classification models based on machine learning algorithms for each schooling period, and further analyze the similarities and differences in the factors influencing myopia in each school period based on ea…
View article: Related factors leading to sex ratio differences at birth in assisted reproductive technology pregnancies: A retrospective cohort study
Related factors leading to sex ratio differences at birth in assisted reproductive technology pregnancies: A retrospective cohort study Open
Background This study aimed to determine the effect of in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and individual factors on the sex ratio of offspring at birth in China. Methods This retrospective cohort study a…
View article: Identifying stroke-related quantified evidence from electronic health records in real-world studies
Identifying stroke-related quantified evidence from electronic health records in real-world studies Open
Stroke is one of the leading causes of death and disability worldwide. The National Institutes of Health Stroke Scale (NIHSS) scores in electronic health records (EHRs), which quantitatively describe patients' neurological deficits in evid…