Dingchang Lin
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View article: Genetically encoded assembly recorder temporally resolves cellular histories <i>in cellulo</i> and <i>in vivo</i>
Genetically encoded assembly recorder temporally resolves cellular histories <i>in cellulo</i> and <i>in vivo</i> Open
Mapping cellular activity with high spatiotemporal precision in complex tissues is essential for understanding organ physiology, pathology, and regenerative processes. Here, we introduce G ranularly E xpanding M emory for I ntracellular N …
View article: Use of polyadenosine tail mimetics to enhance mRNA expression from genes associated with haploinsufficiency disorders
Use of polyadenosine tail mimetics to enhance mRNA expression from genes associated with haploinsufficiency disorders Open
Polyadenosine (poly(A)) tails are nearly ubiquitous in human messenger RNA (mRNA) governing mRNA stability and translation. Crucially, the poly(A) tail regulates cytoplasmic gene expression by undergoing controlled removal upon exposure to…
View article: Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation
Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation Open
Mammalian cells rapidly respond to environmental changes by altering transmembrane water and ion fluxes, changing cell volume. Contractile forces generated by actomyosin have been proposed to mechanically regulate cell volume. However, our…
View article: The ultra-thin, minimally invasive surface electrode array NeuroWeb for probing neural activity
The ultra-thin, minimally invasive surface electrode array NeuroWeb for probing neural activity Open
Electrophysiological recording technologies can provide valuable insights into the functioning of the central and peripheral nervous systems. Surface electrode arrays made of soft materials or implantable multi-electrode arrays with high e…
View article: Injectable ventral spinal stimulator evokes programmable and biomimetic hindlimb motion
Injectable ventral spinal stimulator evokes programmable and biomimetic hindlimb motion Open
Spinal cord neuromodulation can restore partial to complete loss of motor functions associated with neuromotor disease and trauma. Current technologies have made substantial progress, but have limitations as dorsal epidural or intraspinal …
View article: ProGroTrack: Deep Learning-Assisted Tracking of Intracellular Protein Growth Dynamics
ProGroTrack: Deep Learning-Assisted Tracking of Intracellular Protein Growth Dynamics Open
Accurate tracking of cellular and subcellular structures, along with their dynamics, plays a pivotal role in understanding the underlying mechanisms of biological systems. This paper presents a novel approach, ProGroTrack, that combines th…
View article: Stitching Flexible Electronics into the Brain
Stitching Flexible Electronics into the Brain Open
Understanding complex neuronal networks requires monitoring long‐term neuronal activity in various regions of the brain. Significant progress has been made in multisite implantations of well‐designed probes, such as multisite implantation …
View article: Stitching flexible electronics into the brain
Stitching flexible electronics into the brain Open
Understanding complex neuronal networks requires monitoring long-term neuronal activity in various regions of the brain. Significant progress has been made in multi-site implantations of well-designed probes, such as multi-site implantatio…
View article: Composite lithium metal anodes for lithium batteries with reduced volumetric fluctuation during cycling and dendrite suppression
Composite lithium metal anodes for lithium batteries with reduced volumetric fluctuation during cycling and dendrite suppression Open
A lithium battery includes a cathode, a composite lithium metal anode, and an electrolyte in contact with the cathode and the composite lithium metal anode. The composite lithium metal anode includes a porous matrix and lithium metal dispo…
View article: Time-tagged ticker tapes for intracellular recordings
Time-tagged ticker tapes for intracellular recordings Open
A core taken in a tree today can reveal climate events from centuries past. Here we adapt this idea to record histories of neural activation. We engineered slowly growing intracellular protein fibers which can incorporate diverse fluoresce…
View article: Nanoenabled Direct Contact Interfacing of Syringe-Injectable Mesh Electronics
Nanoenabled Direct Contact Interfacing of Syringe-Injectable Mesh Electronics Open
Polymer-based electronics with low bending stiffnesses and high flexibility, including recently reported macroporous syringe-injectable mesh electronics, have shown substantial promise for chronic studies of neural circuitry in the brains …
View article: Single-cell profiles of retinal neurons differing in resilience to injury reveal neuroprotective genes
Single-cell profiles of retinal neurons differing in resilience to injury reveal neuroprotective genes Open
Summary Neuronal types in the central nervous system differ dramatically in their resilience to injury or insults. Here we studied the selective resilience of mouse retinal ganglion cells (RGCs) following optic nerve crush (ONC), which sev…
View article: Direct/Alternating Current Electrochemical Method for Removing and Recovering Heavy Metal from Water Using Graphene Oxide Electrode
Direct/Alternating Current Electrochemical Method for Removing and Recovering Heavy Metal from Water Using Graphene Oxide Electrode Open
Treatment of heavy-metal pollution in both point-of-use water and industrial wastewater is critical in protecting human health and the environment. Current methods for heavy-metal treatment in both sources have limitations. For point-of-us…
View article: Uniform High Ionic Conducting Lithium Sulfide Protection Layer for Stable Lithium Metal Anode
Uniform High Ionic Conducting Lithium Sulfide Protection Layer for Stable Lithium Metal Anode Open
Artificial solid‐electrolyte interphase (SEI) is one of the key approaches in addressing the low reversibility and dendritic growth problems of lithium metal anode, yet its current effect is still insufficient due to insufficient stability…
View article: Composite lithium electrode with mesoscale skeleton via simple mechanical deformation
Composite lithium electrode with mesoscale skeleton via simple mechanical deformation Open
By a simple but effective physical method, lithium can be wrapped inside a polymer matrix, creating a 3D composite electrode.
View article: Wrinkled Graphene Cages as Hosts for High-Capacity Li Metal Anodes Shown by Cryogenic Electron Microscopy
Wrinkled Graphene Cages as Hosts for High-Capacity Li Metal Anodes Shown by Cryogenic Electron Microscopy Open
Lithium (Li) metal has long been considered the "holy grail" of battery anode chemistry but is plagued by low efficiency and poor safety due to its high chemical reactivity and large volume fluctuation, respectively. Here we introduce a ne…
View article: An Interconnected Channel‐Like Framework as Host for Lithium Metal Composite Anodes
An Interconnected Channel‐Like Framework as Host for Lithium Metal Composite Anodes Open
Lithium (Li) metal anodes have long been counted on to meet the increasing demand for high energy, high‐power rechargeable battery systems but they have been plagued by uncontrollable plating, unstable solid electrolyte interphase (SEI) fo…
View article: Spectrally Selective Nanocomposite Textile for Outdoor Personal Cooling
Spectrally Selective Nanocomposite Textile for Outdoor Personal Cooling Open
Outdoor heat stress poses a serious public health threat and curtails industrial labor supply and productivity, thus adversely impacting the wellness and economy of the entire society. With climate change, there will be more intense and fr…
View article: A Silica‐Aerogel‐Reinforced Composite Polymer Electrolyte with High Ionic Conductivity and High Modulus
A Silica‐Aerogel‐Reinforced Composite Polymer Electrolyte with High Ionic Conductivity and High Modulus Open
High‐energy all‐solid‐state lithium (Li) batteries have great potential as next‐generation energy‐storage devices. Among all choices of electrolytes, polymer‐based systems have attracted widespread attention due to their low density, low c…