Dingding Han
YOU?
Author Swipe
View article: Association between immune cells and breast cancer: A two-sample Mendelian randomization study
Association between immune cells and breast cancer: A two-sample Mendelian randomization study Open
This study explored the potential causal relationship between circulating immune cells and breast cancer incidence through a 2-sample Mendelian randomization (MR) approach using inverse-variance weighting, Weighted Median and MR-Egger regr…
View article: 20-Hydroxyecdysone Modulates Bmp53-Mediated Apoptosis Regulation by Suppressing Mdm2-like-Dependent Ubiquitination in Silkworm, Bombyx mori
20-Hydroxyecdysone Modulates Bmp53-Mediated Apoptosis Regulation by Suppressing Mdm2-like-Dependent Ubiquitination in Silkworm, Bombyx mori Open
In the silkworm, 20-hydroxyecdysone (20E) induces apoptosis and autophagy, driving larval organ degeneration and remodeling. This mechanism may be a potential target for eco-friendly strategy for insect pests. However, a major challenge in…
View article: Evaluation of Cloud Mask Performance of KOMPSAT-3 Top-of-Atmosphere Reflectance Incorporating Deeplabv3+ with Resnet 101 Model
Evaluation of Cloud Mask Performance of KOMPSAT-3 Top-of-Atmosphere Reflectance Incorporating Deeplabv3+ with Resnet 101 Model Open
Cloud detection is a crucial task in satellite remote sensing, influencing applications such as vegetation indices, land use analysis, and renewable energy estimation. This study evaluates the performance of cloud masks generated for KOMPS…
View article: Investigating Groundwater–Surface Water Interactions and Transformations in a Typical Dry–Hot Valley Through Environmental Isotopes Analysis
Investigating Groundwater–Surface Water Interactions and Transformations in a Typical Dry–Hot Valley Through Environmental Isotopes Analysis Open
This study investigates the hydrological processes and water body transformation mechanisms in the Yuanmou dry–hot valley, focusing on precipitation, well water, spring water, river water, and reservoir water, during both wet and dry seaso…
View article: Cascading Failure and Recovery Model for Subway Network Systems Considering Resource Allocation and Passenger Evacuation
Cascading Failure and Recovery Model for Subway Network Systems Considering Resource Allocation and Passenger Evacuation Open
Subway systems serve as vital components of urban transportation infrastructure. Due to the critical concern for transportation safety, research on the resilience and recovery capabilities of subway systems is therefore of great significan…
View article: New Insights into the Epidemiological Characteristics of Mycoplasma pneumoniae Infection before and after the COVID-19 Pandemic
New Insights into the Epidemiological Characteristics of Mycoplasma pneumoniae Infection before and after the COVID-19 Pandemic Open
Mycoplasma pneumoniae (M. pneumoniae), a prevalent respiratory pathogen affecting children and adolescents, is known to trigger periodic global epidemics. The most recent significant outbreak commenced in the first half of 2023 and reached…
View article: TMErisk score: A tumor microenvironment-based model for predicting prognosis and immunotherapy in patients with head and neck squamous cell carcinoma
TMErisk score: A tumor microenvironment-based model for predicting prognosis and immunotherapy in patients with head and neck squamous cell carcinoma Open
View article: Investigation of Medium-Term Performance of Porous Asphalt and Its Impacts on Tire/Pavement Noise
Investigation of Medium-Term Performance of Porous Asphalt and Its Impacts on Tire/Pavement Noise Open
To assess the medium-term performance of porous asphalt pavement during service and its influence on tire/pavement noise level, a seven-year continuous observation and data analysis study was conducted. Key performance indicators were meas…
View article: Altered intestinal microbiota enhances adenoid hypertrophy by disrupting the immune balance
Altered intestinal microbiota enhances adenoid hypertrophy by disrupting the immune balance Open
Introduction Adenoid hypertrophy (AH) is a common upper respiratory disorder in children. Disturbances of gut microbiota have been implicated in AH. However, the interplay of alteration of gut microbiome and enlarged adenoids remains elusi…
View article: Recent Advances in Bacterial Persistence Mechanisms
Recent Advances in Bacterial Persistence Mechanisms Open
The recurrence of bacterial infectious diseases is closely associated with bacterial persisters. This subpopulation of bacteria can escape antibiotic treatment by entering a metabolic status of low activity through various mechanisms, for …
View article: Epigenetic regulation of human-specific gene expression in the prefrontal cortex
Epigenetic regulation of human-specific gene expression in the prefrontal cortex Open
Background Changes in gene expression levels during brain development are thought to have played an important role in the evolution of human cognition. With the advent of high-throughput sequencing technologies, changes in brain developmen…
View article: Clinical Application of a Multiplex Droplet Digital PCR in the Rapid Diagnosis of Children with Suspected Bloodstream Infections
Clinical Application of a Multiplex Droplet Digital PCR in the Rapid Diagnosis of Children with Suspected Bloodstream Infections Open
Droplet digital PCR (ddPCR) recently has been shown to be a potential diagnostic tool for adults with bloodstream infections (BSIs); however, its application in children remains obscure. In this study, 76 blood samples of children with sus…
View article: Association between Intestinal Colonization and Extraintestinal Infection with Carbapenem-Resistant Klebsiella pneumoniae in Children
Association between Intestinal Colonization and Extraintestinal Infection with Carbapenem-Resistant Klebsiella pneumoniae in Children Open
Carbapenem-resistant Klebsiella pneumoniae (CRKP) causes an increasing number of nosocomial infections, which can be life-threatening, as carbapenems are last-resort antibiotics. K. pneumoniae is part of the healthy human microbiome, and t…
View article: Design and Application of Intelligent Transportation Multi-Source Data Collaboration Framework Based on Digital Twins
Design and Application of Intelligent Transportation Multi-Source Data Collaboration Framework Based on Digital Twins Open
The increasing urban traffic problems have made the transportation system require a large amount of data. Aiming at the current problems of data types redundancy and low coordination rate of intelligent transportation systems (ITS), this p…
View article: Integrative Analysis of Single-Cell Embryo Data Reveals Transcriptome Signatures for the Human Pre-Implantation Inner Cell Mass
Integrative Analysis of Single-Cell Embryo Data Reveals Transcriptome Signatures for the Human Pre-Implantation Inner Cell Mass Open
View article: Basins of attraction of chimera states on networks
Basins of attraction of chimera states on networks Open
Networks of identical coupled oscillators display a remarkable spatiotemporal pattern, the chimera state, where coherent oscillations coexist with incoherent ones. In this paper we show quantitatively in terms of basin stability that stabl…
View article: Nosocomial dissemination of hypervirulent Klebsiella pneumoniae with high-risk clones among children in Shanghai
Nosocomial dissemination of hypervirulent Klebsiella pneumoniae with high-risk clones among children in Shanghai Open
Objectives Although hypervirulent Klebsiella pneumoniae (hvKp) is an increasing public health problem, there remains limited epidemiological information regarding hvKp infections in children. Here, we conducted a clinical, molecular and ph…
View article: Author response: Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity
Author response: Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Developmental trajecto…
View article: Genetic Characteristics and Microbiological Profile of Hypermucoviscous Multidrug-Resistant Klebsiella variicola Coproducing IMP-4 and NDM-1 Carbapenemases
Genetic Characteristics and Microbiological Profile of Hypermucoviscous Multidrug-Resistant Klebsiella variicola Coproducing IMP-4 and NDM-1 Carbapenemases Open
As an important member of the Klebsiella pneumoniae complex, Klebsiella variicola is poorly studied as an emerging human pathogen. We, for the first time, report a unique K. variicola isolated from a pediatric patient in China.
View article: Curcumin Synergistically Enhances the Cytotoxicity of Arsenic Trioxide in U266 Cells by Increasing Arsenic Uptake
Curcumin Synergistically Enhances the Cytotoxicity of Arsenic Trioxide in U266 Cells by Increasing Arsenic Uptake Open
Despite the constant emergence of new methods for the treatment of multiple myeloma (MM), relapse and drug resistance still exist, especially in MM with p53 mutations. Arsenic trioxide (ATO) can be used in MM treatment, but this single dru…
View article: Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients
Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients Open
View article: Hypomorphic and hypermorphic mouse models of <i>Fsip2</i> indicate its dosage-dependent roles in sperm tail and acrosome formation
Hypomorphic and hypermorphic mouse models of <i>Fsip2</i> indicate its dosage-dependent roles in sperm tail and acrosome formation Open
Loss-of-function mutations in multiple morphological abnormalities of the sperm flagella (MMAF)-associated genes lead to decreased sperm motility and impaired male fertility. As an MMAF gene, the function of fibrous sheath-interacting prot…
View article: In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy
In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy Open
Cerebral palsy is the most prevalent physical disability in children; however, its inherent molecular mechanisms remain unclear. In the present study, we performed in-depth clinical and molecular analysis on 120 idiopathic cerebral palsy f…
View article: Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1
Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1 Open
View article: Upregulation of Nogo‐B by hypoxia inducible factor‐1 and activator protein‐1 in hepatocellular carcinoma
Upregulation of Nogo‐B by hypoxia inducible factor‐1 and activator protein‐1 in hepatocellular carcinoma Open
Nogo‐B is an important regulator of tumor angiogenesis. Expression of Nogo‐B is remarkably upregulated in multiple tumor types, especially hepatocellular carcinoma (HCC). Here, we show the transcriptional regulation mechanisms of Nogo‐B in…
View article: Variation of microRNA expression in the human placenta driven by population identity and sex of the newborn
Variation of microRNA expression in the human placenta driven by population identity and sex of the newborn Open
View article: Bi-allelic mutation in Fsip1 impairs acrosome vesicle formation and attenuates flagellogenesis in mice
Bi-allelic mutation in Fsip1 impairs acrosome vesicle formation and attenuates flagellogenesis in mice Open
Fibrous sheath interacting protein 1 (Fsip1) is a cytoskeletal structural protein of the sperm flagellar proteome. A few studies have reported that it plays a vital role in the tumorigenesis and cancer progression. However, little is known…
View article: Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity
Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity Open
Developmental trajectories of gene expression may reverse in their direction during ageing, a phenomenon previously linked to cellular identity loss. Our analysis of cerebral cortex, lung, liver and muscle transcriptomes of 16 mice, coveri…
View article: An Evaluation of Morphological Changes and Deformability of Suspended Red Blood Cells Prepared Using Whole Blood with Different Hemoglobin Levels of Tibetans
An Evaluation of Morphological Changes and Deformability of Suspended Red Blood Cells Prepared Using Whole Blood with Different Hemoglobin Levels of Tibetans Open
Background: The hypoxic environment stimulates the human body to increase the levels of hemoglobin (HGB) and hematocrit and the number of red blood cells. Such enhancements have individual differences, leading to a wide range…
View article: Additional file 2 of Variation of microRNA expression in the human placenta driven by population identity and sex of the newborn
Additional file 2 of Variation of microRNA expression in the human placenta driven by population identity and sex of the newborn Open
Additional file 2: Table S2. List of miRNA sequencing files and statistics of mapping.