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View article: Seven New Irbesartan Salts: Significantly Improved Dissolution, Excellent Hygrothermal Stability, and Characteristic Supramolecular Synthons
Seven New Irbesartan Salts: Significantly Improved Dissolution, Excellent Hygrothermal Stability, and Characteristic Supramolecular Synthons Open
Irbesartan (IRB) is a commonly used BCS Class II antihypertensive drug requiring dissolving capacity enhancement to address oral bioavailability limitations. In this work, seven new IRB salts were successfully synthesized, including one ca…
View article: The Stirring Effect on the Crystal Morphology of p-Acetamidobenzoic Acid Solution Crystallization
The Stirring Effect on the Crystal Morphology of p-Acetamidobenzoic Acid Solution Crystallization Open
This work investigates the stirring effect on p-Acetamidobenzoic Acid (p -AABA) crystal morphology through single crystal cultivation, crystal face growth rate, and nucleation supersaturation measurements, molecular simulation (MS), and co…
View article: Structural insights into activation mechanisms on NADase of the bacterial DSR2 anti-phage defense system
Structural insights into activation mechanisms on NADase of the bacterial DSR2 anti-phage defense system Open
As a sirtuin (SIR2) family protein, defense-associated sirtuin2 (DSR2) has been demonstrated to participate in bacterial anti-phage resistance via depleting nicotinamide adenine dinucleotide (NAD + ) of infected cells, which can be activat…
View article: CO2 Promoting Polymorphic Transformation of Clarithromycin: Polymorph Characterization, Pathway Design, and Mechanism Study
CO2 Promoting Polymorphic Transformation of Clarithromycin: Polymorph Characterization, Pathway Design, and Mechanism Study Open
Carbon dioxide (CO2) has a wide range of uses such as food additives and raw materials for synthetic chemicals, while its application in the solid-state transformation of pharmaceutical crystals is rare. In this work, we report a case of u…
View article: Structural Characteristics of Polysaccharide GP2a in Gardenia jasminoides and Its Immunomodulatory Effect on Macrophages
Structural Characteristics of Polysaccharide GP2a in Gardenia jasminoides and Its Immunomodulatory Effect on Macrophages Open
Here, we elucidated the structural characteristics of a polysaccharide isolated from Gardenia jasminoides Ellis (labeled as GP2a) and its immunomodulatory activity. GP2a is an acidic polysaccharide with a molecular weight of 44.8 kDa, most…
View article: Salts of 2-hydroxybenzylamine with improvements on solubility and stability: Virtual and experimental screening
Salts of 2-hydroxybenzylamine with improvements on solubility and stability: Virtual and experimental screening Open
2-Hydroxybenzylamine (2-HOBA) is a drug used to effectively treat oxidative stress. To improve its aqueous solubility and thermal stability, salt screening and synthesis was carried out. The conductor-like screening model for the real solv…