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View article: Novel Location-Grading-Node-Metastasis Staging System in Patients With Head and Neck Soft Tissue Sarcoma
Novel Location-Grading-Node-Metastasis Staging System in Patients With Head and Neck Soft Tissue Sarcoma Open
Importance Unlike other head and neck cancers, head and neck soft tissue sarcoma (HN-STS) is staged similarly to sarcomas in the trunk and extremities. The current American Joint Committee on Cancer (AJCC) staging system has limitations th…
View article: A novel systemic inflammatory-nutritional score (INS) and nomogram for the prognostic prediction of adult head and neck soft tissue sarcoma in patients undergoing R0 surgery
A novel systemic inflammatory-nutritional score (INS) and nomogram for the prognostic prediction of adult head and neck soft tissue sarcoma in patients undergoing R0 surgery Open
Background Head and neck soft tissue sarcoma (HNSTS) comprises a rare group of malignancies with high risks of recurrence and mortality. However, the biomarkers predicting the prognosis of HNSTS patients received R0 resection are limited. …
View article: Senotherapy Protects against Cisplatin‐Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage
Senotherapy Protects against Cisplatin‐Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage Open
Ovarian damage induced by platinum‐based chemotherapy seriously affects young women with cancer, manifesting as infertility, early menopause, and premature ovarian insufficiency. However, effective prevention strategies for such damage are…
View article: TNF Patterns and Tumor Microenvironment Characterization in Head and Neck Squamous Cell Carcinoma
TNF Patterns and Tumor Microenvironment Characterization in Head and Neck Squamous Cell Carcinoma Open
Background HNSCC is a heterogeneous disease, which arises from distinct anatomic subsites, associates with various risk factors and possesses diverse molecular pathological features. Generally, HNSCC is considered as an immunosuppressive d…
View article: Epigallocatechin gallate and theaflavins independently alleviate cyclophosphamide-induced ovarian damage by inhibiting the overactivation of primordial follicles and follicular atresia
Epigallocatechin gallate and theaflavins independently alleviate cyclophosphamide-induced ovarian damage by inhibiting the overactivation of primordial follicles and follicular atresia Open
The present study showed that EGCG and TFs independently improved ovarian function in mice with CTX-induced ovarian damage, thereby providing useful information for designing a potential clinical strategy that will protect against chemothe…
View article: Metformin prevents murine ovarian aging
Metformin prevents murine ovarian aging Open
A number of studies have shown that metformin can delay aging process and extend healthy lifespan in animals. However, its role in female reproductive lifespan is unclear. This study was aimed to explore the potential anti-aging effect of …
View article: Can ovarian aging be delayed by pharmacological strategies?
Can ovarian aging be delayed by pharmacological strategies? Open
Aging has been regarded as a treatable condition, and delaying aging could prevent some diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as ovaries exhibit an accelerated rate of aging with characte…