Dingka Song
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View article: Genetic Variations and Haplotype Diversity of the Wheat FRIZZY PANICLE (WFZP) Gene in 98 Aegilops tauschii Accessions
Genetic Variations and Haplotype Diversity of the Wheat FRIZZY PANICLE (WFZP) Gene in 98 Aegilops tauschii Accessions Open
Background: The wheat FRIZZY PANICLE (WFZP) gene is a regulatory hub that controls spikelet formation in bread wheat, WFZP-D, as a favorable gene for wheat yield improvement. The sequences of WFZP-D in bread wheat accessions are known to b…
View article: Development and characterization of small translocations between the Pm13 introgression from Aegilops longissima and wheat homoeologous A, B and D chromosomes
Development and characterization of small translocations between the Pm13 introgression from Aegilops longissima and wheat homoeologous A, B and D chromosomes Open
Our results provide novel alien homoeologous Pm13 translocations for improving powdery mildew resistance in wheat and insights into the interactions between different wheat genomes and alien chromosome segments.
View article: Clec12a inhibits MSU-induced immune activation through lipid raft expulsion
Clec12a inhibits MSU-induced immune activation through lipid raft expulsion Open
Monosodium uric acid (MSU) crystal, the etiological agent of gout, has been shown to trigger innate immune responses via multiple pathways. It is known that MSU-induced lipid sorting on plasma membrane promotes the phosphorylation of Syk a…
View article: Bi-directional epithelial-immune communication amplifies inflammasome activation and IL-6 release during SARS-CoV-2 infection
Bi-directional epithelial-immune communication amplifies inflammasome activation and IL-6 release during SARS-CoV-2 infection Open
Increased levels of the pro-inflammatory cytokines IL-1β and IL-6 are linked to severe COVID-19. Here, we investigate the contributions of viral host cells, primary human airway epithelia (HAE), and immune bystanders, peripheral blood mono…
View article: Beneficial insights into postbiotics against colorectal cancer
Beneficial insights into postbiotics against colorectal cancer Open
Colorectal cancer (CRC) is one of the most prevalent and life-threatening cancer types with limited therapeutic options worldwide. Gut microbiota has been recognized as the pivotal determinant in maintaining gastrointestinal (GI) tract hom…
View article: Dietary fungi in cancer immunotherapy: From the perspective of gut microbiota
Dietary fungi in cancer immunotherapy: From the perspective of gut microbiota Open
Immunotherapies are recently emerged as a new strategy in treating various kinds of cancers which are insensitive to standard therapies, while the clinical application of immunotherapy is largely compromised by the low efficiency and serio…
View article: Development and treatment of colorectal cancer: Insights from multi‐kingdom microbiota
Development and treatment of colorectal cancer: Insights from multi‐kingdom microbiota Open
Colorectal cancer (CRC) is a multistage and highly heterogeneous malignant disease that mostly occurred in aged people accompanied by microbiota alteration. Emerging evidence has uncovered the role of bacterial microbiota in the initiation…
View article: Cytotoxicity and Antimicrobial Resistance of Salmonella enterica Subspecies Isolated from Raised Reptiles in Beijing, China
Cytotoxicity and Antimicrobial Resistance of Salmonella enterica Subspecies Isolated from Raised Reptiles in Beijing, China Open
Background: Reptiles are asymptomatic carriers of Salmonella spp. Reptile-associated Salmonella infections have been noticed as a significant contributor to overall human salmonellosis. However, it remains unclear regarding the prevalence …
View article: An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2
An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2 Open
View article: STING-induced regulatory B cells compromise NK function in cancer immunity
STING-induced regulatory B cells compromise NK function in cancer immunity Open
View article: STING-induced regulatory B cells compromise NK function in cancer immunity
STING-induced regulatory B cells compromise NK function in cancer immunity Open
An immunosuppressive tumour microenvironment is a major obstacle in the control of pancreatic and other solid cancers1–3. Agonists of the stimulator of interferon genes (STING) protein trigger inflammatory innate immune responses to potent…
View article: An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2
An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2 Open
Elevated levels of cytokines IL-1β and IL-6 are associated with severe COVID-19. Investigating the underlying mechanisms, we find that while primary human airway epithelia (HAE) have functional inflammasomes and support SARS-CoV-2 replicat…