Dingke Wen
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View article: Impact of Prevertebral Fascia Suture and Relevant Risk Factors on Postoperative Dysphagia Following Anterior Cervical Discectomy and Fusion
Impact of Prevertebral Fascia Suture and Relevant Risk Factors on Postoperative Dysphagia Following Anterior Cervical Discectomy and Fusion Open
Objectives The prevertebral fascia (PVF), which constitutes part of the deep layer of the deep cervical fascia, is routinely incised during anterior cervical discectomy and fusion (ACDF) surgery. Suturing the PVF could serve as an optimal …
View article: Melanoma cell adhesion molecule-positive mesenchymal stromal cells alleviate acute respiratory distress syndrome <i>via</i> nuclear factor kappa-B-mediated paracrine regulation
Melanoma cell adhesion molecule-positive mesenchymal stromal cells alleviate acute respiratory distress syndrome <i>via</i> nuclear factor kappa-B-mediated paracrine regulation Open
BACKGROUND Mesenchymal stromal cells (MSCs) are renowned for their immunosuppressive properties, which make them widely used in managing excessive inflammation. Although CD146+ and CD146- MSCs exhibit similar morphological traits and surfa…
View article: Long-term efficacy and safety of JAKi in refractory livedoid vasculopathy
Long-term efficacy and safety of JAKi in refractory livedoid vasculopathy Open
View article: Longitudinal Imaging of Experimental Intracerebral Hemorrhage Pathology with Iodine-enhanced Micro-CT
Longitudinal Imaging of Experimental Intracerebral Hemorrhage Pathology with Iodine-enhanced Micro-CT Open
Background Iodine-enhanced micro-computed tomography (Micro-CT) enables high-resolution three-dimensional imaging of brain architecture. This study aimed to characterize both acute and chronic pathological changes following intracerebral h…
View article: Association between the stress hyperglycemia ratio and all-cause mortality in patients with hemorrhagic stroke: a retrospective analysis based on MIMIC-IV database
Association between the stress hyperglycemia ratio and all-cause mortality in patients with hemorrhagic stroke: a retrospective analysis based on MIMIC-IV database Open
Background Research on the associations between the stress hyperglycemia ratio (SHR) and adverse outcomes in patients with hemorrhagic stroke is limited. Therefore, we aimed to investigate the relationship between the SHR and all-cause mor…
View article: Association between triglyceride-glucose index and risk of acute kidney injury in patients with aneurysmal subarachnoid hemorrhage
Association between triglyceride-glucose index and risk of acute kidney injury in patients with aneurysmal subarachnoid hemorrhage Open
The TyG index is an independent predictor of AKI and mortality in aSAH patients. Its incorporation into clinical assessment facilitates early risk stratification and individualized management.
View article: Cribriform Plate Lymphatics Bear Rapid Erythrocyte Clearance after Experimental Intracerebral Hemorrhage
Cribriform Plate Lymphatics Bear Rapid Erythrocyte Clearance after Experimental Intracerebral Hemorrhage Open
View article: Systemic treatment type is not associated with abnormal post-treatment noninvasive liver stiffness measurement in psoriasis
Systemic treatment type is not associated with abnormal post-treatment noninvasive liver stiffness measurement in psoriasis Open
Background Psoriasis is commonly associated with metabolic dysfunction-associated steatotic liver disease, raising concerns about the hepatic effects of systemic treatments on psoriasis and its comorbid conditions. This study evaluates liv…
View article: Does the Angulation of the Screws in the Zero‐P Implant Affect the Clinical and Radiological Outcomes of Patients?
Does the Angulation of the Screws in the Zero‐P Implant Affect the Clinical and Radiological Outcomes of Patients? Open
Objective When implanting the Zero‐P device, the screws of Zero‐P form a bone wedge with a 40 ± 5° cranial and caudal angle (CCA). However, no study has been performed in the optimal CCA of the Zero‐P implant. To investigate whether the cr…
View article: Tetrahedral DNA loaded siCCR2 restrains M1 macrophage polarization to ameliorate pulmonary fibrosis in chemoradiation-induced murine model
Tetrahedral DNA loaded siCCR2 restrains M1 macrophage polarization to ameliorate pulmonary fibrosis in chemoradiation-induced murine model Open
Idiopathic pulmonary fibrosis (IPF) is a chronic lethal disease in the absence of demonstrated efficacy for preventing progression. Although macrophage-mediated alveolitis is determined to participate in myofibrotic transition during disea…
View article: The prognostic value of an age-adjusted BIG score in adult patients with traumatic brain injury
The prognostic value of an age-adjusted BIG score in adult patients with traumatic brain injury Open
Background The base deficit, international normalized ratio, and Glasgow Coma Scale (BIG) score was previously developed to predict the outcomes of pediatric trauma patients. We designed this study to explore and improve the prognostic val…
View article: Novel Low-Density Lipoprotein Cholesterol Reduction Therapies for the Secondary Prevention of Cardiovascular Disease
Novel Low-Density Lipoprotein Cholesterol Reduction Therapies for the Secondary Prevention of Cardiovascular Disease Open
The present analysis showed that bempedoic acid ranked first in reducing the risk of a composite cardiovascular outcome. In addition, it ranked first in reducing the risk of new-onset diabetes compared with placebo and evolocumab. Our anal…
View article: A Propensity Score-Matched Study on the Changes of TB Status and TB-IGRA Values in Patients with Psoriasis with Latent TB Receiving Secukinumab
A Propensity Score-Matched Study on the Changes of TB Status and TB-IGRA Values in Patients with Psoriasis with Latent TB Receiving Secukinumab Open
View article: Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progression
Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progression Open
Background Multiple sclerosis (MS) leads to demyelination and neurodegeneration with autoimmune responses in central nervous system. Patients begin with a relapsing–remitting (RR) course, and more than 80% of them may advance to secondary …
View article: Additional file 2 of Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progression
Additional file 2 of Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progression Open
Additional file 2. Table S1.
View article: Comprehensive analysis of immune cell infiltration and role of <scp>MSR1</scp> expression in aneurysmal subarachnoid haemorrhage
Comprehensive analysis of immune cell infiltration and role of <span>MSR1</span> expression in aneurysmal subarachnoid haemorrhage Open
Aneurysmal subarachnoid haemorrhage (aSAH), resulting from the rupture of intracranial aneurysms, can yield high mortality and disability. This study aimed to explore the immune infiltration of aneurysmal tissues and investigate a novel me…
View article: Peripheral monocyte count is associated with hematoma clearance after intracerebral hemorrhage: a multicenter retrospective study
Peripheral monocyte count is associated with hematoma clearance after intracerebral hemorrhage: a multicenter retrospective study Open
Background Promoting hematoma clearance after intracerebral hemorrhage (ICH) can reduce secondary brain injury. However, factors influencing hematoma resolution remain unclear. We aimed to explore the factors influence hematoma clearance a…
View article: The prognostic value of the Charlson comorbidity index in aged patients with intracerebral hemorrhage
The prognostic value of the Charlson comorbidity index in aged patients with intracerebral hemorrhage Open
View article: Effect of corticosteroids in patients with COVID-19: a Bayesian network meta-analysis
Effect of corticosteroids in patients with COVID-19: a Bayesian network meta-analysis Open
Administration of corticosteroids was associated with a reduced all-cause mortality at 28 days compared with placebo or usual care. Our analysis also confirmed the mortality benefit associated with low-dose and long-term treatment with cor…
View article: Identification of the key immune-related genes in aneurysmal subarachnoid hemorrhage
Identification of the key immune-related genes in aneurysmal subarachnoid hemorrhage Open
Subarachnoid hemorrhage (SAH) is a major cause of death and morbidity worldwide, often due to rupture of intracranial aneurysms (IAs). Immune infiltration and inflammatory activation play key roles in the process of aneurysmal SAH (aSAH). …
View article: Efficacy and safety of monoclonal antibody against calcitonin gene-related peptide or its receptor for migraine patients with prior preventive treatment failure: a network meta-analysis
Efficacy and safety of monoclonal antibody against calcitonin gene-related peptide or its receptor for migraine patients with prior preventive treatment failure: a network meta-analysis Open
View article: Clinical characteristics of intracranial aneurysms in elderly patents over 70 years old: a retrospective observational study
Clinical characteristics of intracranial aneurysms in elderly patents over 70 years old: a retrospective observational study Open
View article: “Atypical” Mild Clinical Presentation in Elderly Patients With Ruptured Intracranial Aneurysm: Causes and Clinical Characteristics
“Atypical” Mild Clinical Presentation in Elderly Patients With Ruptured Intracranial Aneurysm: Causes and Clinical Characteristics Open
Objective Thunderclap-like severe headache or consciousness disturbance is the common “typical” clinical presentation after aneurysmal subarachnoid hemorrhage (aSAH); however, a slowly developing “atypical” clinical pattern, with mild head…
View article: Single-Cell RNA Sequencing Reveals the Pathogenic Relevance of Intracranial Atherosclerosis in Blood Blister-Like Aneurysms
Single-Cell RNA Sequencing Reveals the Pathogenic Relevance of Intracranial Atherosclerosis in Blood Blister-Like Aneurysms Open
Background Intracranial non-branching site blood blister-like aneurysms (BBA) are extremely rare and vicious. Their etiology remains elusive, and no molecular study has been carried out to reveal its pathogenic relevance to intracranial at…
View article: PCSK9 inhibitors for secondary prevention in patients with cardiovascular diseases: a bayesian network meta-analysis
PCSK9 inhibitors for secondary prevention in patients with cardiovascular diseases: a bayesian network meta-analysis Open
Background The Food and Drug Administration has approved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) inhibitors for the treatment of dyslipidemia. However, evidence of the optimal PCSK9 agents targeting PCSK9 for secondary preven…
View article: Clinical Characteristics of Intracranial Aneurysms in Elderly Patents over 70 Years Old: a retrospective observational study
Clinical Characteristics of Intracranial Aneurysms in Elderly Patents over 70 Years Old: a retrospective observational study Open
Background Although the characteristics of intracranial aneurysms (IAs) in different age groups have been well documented, they remain relatively unclear in elderly patients due to a lack of large sample studies. Methods Data from IA patie…
View article: Treatment effect of DNA framework nucleic acids on diffuse microvascular endothelial cell injury after subarachnoid hemorrhage
Treatment effect of DNA framework nucleic acids on diffuse microvascular endothelial cell injury after subarachnoid hemorrhage Open
Objectives The purpose of this study was to investigate the treatment effect and molecular mechanism of tetrahedral framework nucleic acids (tFNAs), novel self‐assembled nucleic acid nanomaterials, in diffuse BMEC injury after SAH. Materia…
View article: MicroRNA-210 regulates the metabolic and inflammatory status of primary human astrocytes
MicroRNA-210 regulates the metabolic and inflammatory status of primary human astrocytes Open
Background Astrocytes are the most numerous glial cell type with important roles in maintaining homeostasis and responding to diseases in the brain. Astrocyte function is subject to modulation by microRNAs (miRs), which are short nucleotid…
View article: Reduced M2 macrophages and adventitia collagen dampen the structural integrity of blood blister–like aneurysms and induce preoperative rerupture
Reduced M2 macrophages and adventitia collagen dampen the structural integrity of blood blister–like aneurysms and induce preoperative rerupture Open
Objective Blood blister–like aneurysms (BBAs) are extremely rare aneurysms. They are predisposed to preoperative rerupture with a high case‐fatality rate. Here, we attempt to interrogate the distinct clinicopathology and the histological b…
View article: DC-CTL targeting carbonic anhydrase IX gene combined with iAPA therapy in the treatment of renal cell carcinoma
DC-CTL targeting carbonic anhydrase IX gene combined with iAPA therapy in the treatment of renal cell carcinoma Open
These findings may suggest a novel treatment option for RCC.