Dingkun Lin
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View article: Molecular mechanisms of bone metastasis in breast cancer based on transcriptomic and microbiomic analysis
Molecular mechanisms of bone metastasis in breast cancer based on transcriptomic and microbiomic analysis Open
The study highlights distinct gene expression and gut microbiome differences between BM and BNM patients. HPV infection may play a crucial role in BM development, offering new potential biomarkers and therapeutic targets for early diagnosi…
View article: Optimal timing for the second surgery in staged bilateral total knee arthroplasty: a patient-determined interval approach
Optimal timing for the second surgery in staged bilateral total knee arthroplasty: a patient-determined interval approach Open
Retrospective cohort study, LEVEL III.
View article: Tauroursodeoxycholic acid regulates macrophage/monocyte distribution and improves spinal microenvironment to promote nerve regeneration through inhibiting NF-κB signaling pathway in spinal cord injury
Tauroursodeoxycholic acid regulates macrophage/monocyte distribution and improves spinal microenvironment to promote nerve regeneration through inhibiting NF-κB signaling pathway in spinal cord injury Open
Introduction Following spinal cord injury (SCI), blood-borne monocytes infiltrate the spinal cord, differentiate into macrophages, and dominate the lesion site. Inflammatory responses mediated by macrophages determine nerve regeneration an…
View article: Significant differences in knee kinematics of healthy subjects with high and low anterior tibial laxity
Significant differences in knee kinematics of healthy subjects with high and low anterior tibial laxity Open
Background Anterior tibial laxity is considered to be a risk factor for knee injuries, including anterior cruciate ligament ruptures. The anterior cruciate ligament reconstruction also aims to restore anterior tibial laxity. While anterior…
View article: Microenvironment-responsive injectable hydrogel for neuro-vascularized bone regeneration
Microenvironment-responsive injectable hydrogel for neuro-vascularized bone regeneration Open
View article: A retrospective cohort study: dual cannula combined with modified shoelace continuous capsular closure technique versus nonrepair in hip arthroscopic surgery of femoroacetabular impingement
A retrospective cohort study: dual cannula combined with modified shoelace continuous capsular closure technique versus nonrepair in hip arthroscopic surgery of femoroacetabular impingement Open
View article: Bu Shen Huo Xue Formula Provides Neuroprotection Against Spinal Cord Injury by Inhibits Oxidative Stress by Activating the Nrf2 Signaling Pathway
Bu Shen Huo Xue Formula Provides Neuroprotection Against Spinal Cord Injury by Inhibits Oxidative Stress by Activating the Nrf2 Signaling Pathway Open
BSHXF decreased tissue damage and enhanced functional recovery after SCI by protecting neurons against oxidative stress and apoptosis. The effects of BSHXF on SCI may be related to the activation of the Nrf2 pathway.
View article: Chronic <scp>ACLD</scp> Knees with Early Developmental Cartilage Lesions Exhibited Increased Posterior Tibial Translation during Level Walking
Chronic <span>ACLD</span> Knees with Early Developmental Cartilage Lesions Exhibited Increased Posterior Tibial Translation during Level Walking Open
Objective Early articular cartilage lesion (CL) is a vital sign in the onset of posttraumatic knee osteoarthritis (PTOA) in patients with anterior cruciate ligament deficiency (ACLD). Researchers have suggested that altered kinematics coul…
View article: Capsule closure has better hip function than non-closure in hip arthroscopy for femoracetabular impingement: A systematic review and meta-analysis
Capsule closure has better hip function than non-closure in hip arthroscopy for femoracetabular impingement: A systematic review and meta-analysis Open
Level IV, systematic review of Level I through Level III studies.
View article: Clinical study on the treatment of mild-to-moderate Cervical Spondylotic Radiculopathy by Supine Pulling Manipulation (SPM): study protocol of a randomized controlled trial
Clinical study on the treatment of mild-to-moderate Cervical Spondylotic Radiculopathy by Supine Pulling Manipulation (SPM): study protocol of a randomized controlled trial Open
Background:Cervical spondylotic radiculopathy is a common clinical disease that often presents with neck pain and upper extremity pain. Manipulation has been widely used to treat cervical spondylotic radiculopathy. However,high-quality cli…
View article: Is There an Optimal Time for the Second Surgery of Staged Bilateral Total Knee Arthroplasty When the Intervals Are Determined by Patients?
Is There an Optimal Time for the Second Surgery of Staged Bilateral Total Knee Arthroplasty When the Intervals Are Determined by Patients? Open
Purpose The decision to perform a second surgery in terms of staged bilateral total knee arthroplasty (BTKA) remains undetermined. The purpose of this study was to evaluate the optimal time frame for the second surgery in staged BTKA. Meth…
View article: Is There an Optimal Time for the Second Surgery of Staged Bilateral Total Knee Arthroplasty When the Intervals are Determined by Patients?
Is There an Optimal Time for the Second Surgery of Staged Bilateral Total Knee Arthroplasty When the Intervals are Determined by Patients? Open
View article: Pain Management of Hallux Valgus Surgery Is Achieved by Cocktail Therapy
Pain Management of Hallux Valgus Surgery Is Achieved by Cocktail Therapy Open
Background. Hallux valgus is a relatively common forefoot disease in clinical practice. The aim of our study was to assess the role of local cocktail drugs and postoperative pain after hallux valgus surgery. Methods. A retrospective case-c…
View article: Bu Shen Huo Xue decoction promotes functional recovery in spinal cord injury mice by improving the microenvironment to promote axonal regeneration
Bu Shen Huo Xue decoction promotes functional recovery in spinal cord injury mice by improving the microenvironment to promote axonal regeneration Open
View article: Morphological Variations of the Posterior Superior Iliac Spine in Chinese Population: Potential Effects on the Reliability of Palpation
Morphological Variations of the Posterior Superior Iliac Spine in Chinese Population: Potential Effects on the Reliability of Palpation Open
Objectives . The posterior superior iliac spine (PSIS) is an important anatomical landmark often involved in spinal manipulation and surgical bone harvest. Hence, knowledge of variations in the PSIS may be predictive and valuable in clinic…
View article: Accuracy and Safety of Robot‐Assisted versus Fluoroscopy‐Guided Posterior C1 Lateral Mass and C2 Pedicle Screw Internal Fixation for Atlantoaxial Dislocation: A Preliminary Study
Accuracy and Safety of Robot‐Assisted versus Fluoroscopy‐Guided Posterior C1 Lateral Mass and C2 Pedicle Screw Internal Fixation for Atlantoaxial Dislocation: A Preliminary Study Open
Objective. To compare the accuracy, efficiency, and safety of robotic assistance (RA) and conventional fluoroscopy guidance for the placement of C1 lateral mass and C2 pedicle screws in posterior atlantoaxial fusion. Methods. The data of p…
View article: Would high-dose corticosteroid addition to multimodal cocktail periarticular injection contribute to prolonged pain control and better recovery following total knee arthroplasty?: study protocol for a randomized controlled trial
Would high-dose corticosteroid addition to multimodal cocktail periarticular injection contribute to prolonged pain control and better recovery following total knee arthroplasty?: study protocol for a randomized controlled trial Open
View article: Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response
Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response Open
Background Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid derivative, which has been demonstrated to have neuroprotective effects in different neurological disease models. However, the effect and underlying mechanism of TUDCA…
View article: Would High-Dose Corticosteroid Adjuvant To Multimodal Cocktail Periarticular Injection Contribute To Prolonged Pain Control and Better Recovery After Total Knee Arthroplasty?: Study Protocol for a Double-Blinded, Randomized, and Placebo-Controlled Trial
Would High-Dose Corticosteroid Adjuvant To Multimodal Cocktail Periarticular Injection Contribute To Prolonged Pain Control and Better Recovery After Total Knee Arthroplasty?: Study Protocol for a Double-Blinded, Randomized, and Placebo-Controlled Trial Open
Background Enhanced recovery after total knee arthroplasty (TKA) has been suggested to enhance postoperative recovery. The use of multimodal cocktail periarticular injection (MCPI) to control the pain of TKA has gained wide acceptance. MCP…
View article: Tauroursodeoxycholic Acid Alleviates Secondary Injury in Spinal Cord Injury Mice Through Reducing Oxidative Stress, Apoptosis, and Inflammatory Response
Tauroursodeoxycholic Acid Alleviates Secondary Injury in Spinal Cord Injury Mice Through Reducing Oxidative Stress, Apoptosis, and Inflammatory Response Open
Background Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid derivative, which has been demonstrated to have neuroprotective effects in different neurological disease models. However, the effect and underlying mechanism of TUDCA…
View article: Median nerve compression caused by superficial brachial artery: an unusual clinical case
Median nerve compression caused by superficial brachial artery: an unusual clinical case Open
An iatrogenic pseudoaneurysm of the radial artery and spontaneous venous malformation are associated with median nerve compression. However, the superficial brachial artery (SBA) has rarely been described as the cause of neurological defic…
View article: Clinical Characteristics and Treatment of Spontaneous Osteonecrosis of Medial Tibial Plateau
Clinical Characteristics and Treatment of Spontaneous Osteonecrosis of Medial Tibial Plateau Open
SONK often occurs in the anterior and central tibial plateau due to abnormal stresses. Most of the patients had Level III posterior medial meniscus root tears. MRI is recommended for suspected cases to identify SONK at an early stage. The …
View article: Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice
Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice Open
View article: [Impact of duration of antibiotic therapy on the prognosis of patients with acute myeloid leukemia who had Gram-negative bloodstream infection in consolidation chemotherapy].
[Impact of duration of antibiotic therapy on the prognosis of patients with acute myeloid leukemia who had Gram-negative bloodstream infection in consolidation chemotherapy]. Open
Objectives: To investigate the influence of duration of antibiotic therapy on the prognosis of patients with AML who had Gram-negative bloodstream infection during consolidation chemotherapy. Methods: Data were collected retr…
View article: Primary intraspinal dumbbell-shaped mesenchymal chondrosarcoma with massive calcifications: a case report and review of the literature
Primary intraspinal dumbbell-shaped mesenchymal chondrosarcoma with massive calcifications: a case report and review of the literature Open
View article: Synthesis and biological evaluation of n-butylphthalide derivatives as anti-platelet aggregation agents
Synthesis and biological evaluation of n-butylphthalide derivatives as anti-platelet aggregation agents Open
New analogues of n-butylphthalide (NBP) bearing various lengths of alkyl and different substitution at the two-position of phthalide were designed and synthesised. Preliminary evaluation and prediction of ACD LogP software indicate that th…
View article: The efficacy and safety of the Shaoyao Shujin tablet for knee osteoarthritis: study protocol for a randomized controlled trial
The efficacy and safety of the Shaoyao Shujin tablet for knee osteoarthritis: study protocol for a randomized controlled trial Open
View article: Polydatin Protects Bone Marrow Stem Cells against Oxidative Injury: Involvement of Nrf 2/ARE Pathways
Polydatin Protects Bone Marrow Stem Cells against Oxidative Injury: Involvement of Nrf 2/ARE Pathways Open
Polydatin, a glucoside of resveratrol, has been reported to possess potent antioxidative effects. In the present study, we aimed to investigate the effects of polydatin in bone marrow‐derived mesenchymal stem cells (BMSCs) death caused by …